Invasive Studies of the Human Epileptic Brain

Principles and Practice

Edited by Samden D. Lhatoo, Philippe Kahane, and Hans O. Lüders

Written by some of the most renowned epilepsy experts of the 20th and 21st centuries, the authors provide their expertise and insights into the use of invasive electroencephalography in a variety of clinical situations.
The book is organized into an easily readable series of chapters and is brilliantly illustrated with case studies; each providing an intuitively comprehensive approach to invasive brain studies.

Invasive Studies of the Human Epileptic Brain

Principles and Practice

Edited by Samden D. Lhatoo, Philippe Kahane, and Hans O. Lüders

Description

No other neurological condition allows the same opportunities for an intracranial electrophysiological study of the human brain as epilepsy does. Epileptic surgery is designed to remove the epileptic focus from the human brain, thereby effecting either cure or substantial reduction of seizures in an individual with an otherwise intractable condition. Its use as a treatment modality dates from the late 19th century, and it has become a widely used treatment option throughout the world in the last 20-30 years. The complexity of epilepsy cases in surgical centres, and the need for invasive electrode studies for pre-surgical evaluation, are both greatly increasing.

Invasive Studies of the Human Epileptic Brain is the definitive reference text on the use of invasive electroencephalographic (EEG) diagnostic studies in human epilepsy. Written by some of the most renowned epilepsy experts of the 20th and 21st centuries, the authors provide their expertise and insights into the identification and mapping of intracranial epileptiform and non-epileptiform activity, mapping of the human brain function, and approaches in the use of invasive electroencephalography in a variety of clinical situations.

The book is organized into an easily readable series of chapters and is brilliantly illustrated with case studies; each providing an intuitively comprehensive approach to invasive brain studies.

Invasive Studies of the Human Epileptic Brain

Principles and Practice

Edited by Samden D. Lhatoo, Philippe Kahane, and Hans O. Lüders

Section 1: General overview
1:History of invasive EEG, Hans O. Lüders
2:Principles of invasive EEG, Samden D. Lhatoo, Nuria Lacuey, and Philippe Ryvlin
3:Technical and practical aspects of invasive recordings and brain stimulation, Gholam K. Motamedi, Jean Gotman, and Ronald P. Lesser
4:Subdural grid electrode placement: Approaches and complications, Robert A. McGovern and Guy M. McKhann II
5:Depth electrodes: Approaches and complications, Thomas Ostergard and Jonathan P. Miller
Section 2: Identifying and mapping epileptiform and non-epileptiform activity
6:Physiological activity and artifacts in the human epileptic brain studied with intracerebral depth electrodes EEG, Birgit Frauscher and François Dubeau
7:Physiological activity and artefacts in epileptic brain in subdural EEG, Beate Diehl and Catherine A. Scott
8:The irritative zone and seizure onset zone in subdural EEG, Sebastian Bauer and Felix Rosenow
9:The irritative, epileptogenic and ictal onset zones in depth EEG, Fabrice Bartolomei
10:The irritative zone and seizure onset zone in acute ECoG: The quest for relevant epileptogenic tissue, André Palmini and Eliseu Paglioli
11:High frequency oscillations (HFO), Julia Jacobs
12:Direct current shift recordings, Shasha Wu, Vernon L. Towle, Jonathan P. Miller, and Hans O. Lüders
13:Electrical stimulation for the mapping of the epileptogenic zone, Patrick Landazuri and Lorella Minotti
14:Invasive EEG and hippocampal sclerosis, Jerome Engel, Jr., Richard Staba, and Itzhak Fried
15:Invasive EEG in cortical dysplasia, Laura Tassi and Roberto Mai
16:Invasive EEG in tumoral epilepsy, Francine Chassoux, Elisabeth Landré, and Bertrand Devaux
17:Invasive EEG in tuberous sclerosis, A. Simon Harvey
18:Invasive EEG in gray matter heterotopia, Roberto Mai and Laura Tassi
19:SEEG in polymicrogyria: When and how?, Louis Maillard and Georgia Ramantani
20:Invasive EEG in hypothalamic hamartoma, Julia Scholly, Fabrice Bartolomei, and Edouard Hirsch
Section 3: Invasive EEG approaches in specific clinical situations
21:SEEG in temporal lobe epilepsy, Anne-Sophie Job-Chapron, Lorella Minotti, Dominique Hoffmann, and Philippe Kahane
22:Subdural EEG in temporal lobe epilepsy, Stephan U. Schuele
23:SEEG in frontal lobe epilepsy, Aileen McGonigal and Patrick Chauvel
24:Subdural EEG in frontal lobe epilepsy, Akio Ikeda
25:SEEG in the posterior cortex epilepsies, Stefano Francione, Alexandra Liava, and Francesco Cardinale
26:Subdural EEG in posterior cortex epilepsy, Americo C. Sakamoto, Tonicarlo R. Velasco, and Jorge Gonzalez-Martinez
27:Invasive EEG investigation of the insula, Philippe Ryvlin and Fabienne Picard
28:Depth EEG in sensorimotor cortex epilepsy, Bertrand Devaux, Francine Chassoux, Elisabeth Landré, and Baris Turak
29:Invasive studies of sensory motor cortex epilepsy, Jonathan Edwards, Ekrem Kutluay, and William A. Vandergrift
Section 4: Human brain mapping
30:Human brain mapping using subdural electrodes, Stephanie Gollwitzer and Hajo M. Hamer
31:Intracranial event-related potentials, Milan Brázdil, Pavel Jurák, and Ivan Rektor
32:Cortico-cortical evoked potential mapping, Riki Matsumoto and Takeharu Kunieda
33:Dynamic spectral imaging: Online and offline functional brain mapping using high-frequency activity [50 Hz – 150 Hz] in SEEG, Jean-Philippe Lachaux
Section 5: Therapy using invasive EEG
34:Thermocoagulation of the ictal onset zone using SEEG (thermo-SEEG), Marc Guénot and Pierre Bourdillon
35:Therapeutic stimulation of the ictal onset zone, Mathieu Sprengers, Sofie Carrette, Kristl Vonck, and Paul Boon
Section 6: Special techniques and future prospects
36:Simultaneous macro- and micro-recordings, Michal T. Kucewicz, B. Michael Berry, and Gregory A. Worrell
37:Fast analytical sensing technology: Microelectrode-based recordings of tonic and phasic neurotransmitter signaling in the mamalian brain, Michelle L. Humeiden, Jorge E. Quintero, John T. Slevin, and Greg A. Gerhardt
38:Mapping of seizure networks, Olivier David
39:SEEG recordings: From signal processing to models of epileptogenic networks, Fabrice Wendling, Pascal Benquet, and Fabrice Bartolomei

Invasive Studies of the Human Epileptic Brain

Principles and Practice

Edited by Samden D. Lhatoo, Philippe Kahane, and Hans O. Lüders

Author Information

Edited by Samden D. Lhatoo, Professor of Neurology, Department of Neurology, UH Case Medical Center, Cleveland, OH, USA, Philippe Kahane, Director, Neurology and Psychiatry Department, Grenoble University Hospital, Grenoble, France, and Hans O. Lüders, Professor of Neurology, Department of Neurology, UH Case Medical Center, Cleveland, OH, USA

Samden D. Lhatoo is Professor of Neurology, and Dorothy Blair and Robert Daroff Chair in Neurology, in the Department of Neurology, UH Case Medical Center, Cleveland, OH, USA.

Philippe Kahane is Director of the Unit for Epilepsy and Neurological Diseases at the Neurology and Psychiatry Department, Grenoble University Hospital, Grenoble, France.

Hans O. Lüders is a Professor of Neurology in the Department of Neurology, UH Case Medical Center, Cleveland, OH, USA.

Contributors:

Fabrice Bartolomei, Department of Clinical Neurophysiology, Timone Hospital, Marseille, France

Sebastian Bauer, Department of Neurology and Epilepsy Center, Frankfurt Rhine-Main Goethe University, Frankfurt, Germany

Pascal Benquet, Rennes University, Rennes, France

B. Michael Berry, Department of Neurology and Division of Epilepsy, Mayo Clinic, Rochester, MN, USA

Paul Boon, Department of Neurology, Ghent University Hospital, Ghent, Belgium

Pierre Bourdillon, Department of Functional Neurosurgery, P. Wertheimer Hospital, Lyon, France

Milan Brázdil, Department of Neurology, Faculty of Medicine, Masaryk University, St. Anne´s University Hospital, Brno, Czech Republic

Francesco Cardinale, "Claudio Munari" Epilepsy Surgery Centre, Neuroscience Department, Niguarda Ca' Granda Hospital, Milan, Italy

Sofie Carrette, Department of Neurology, Ghent University Hospital, Ghent, Belgium

Francine Chassoux, Department of Neurosurgery, Sainte-Anne Hospital, Paris, France

Patrick Chauvel, Aix-Marseille University, Medical School, Marseille, France

Olivier David, Grenoble Institute of Neuroscience, GIN, Grenoble, France

Bertrand Devaux, Department of Neurosurgery, Sainte-Anne Hospital, Paris, France

Beate Diehl, UCL Institute of Neurology, London, UK

François Dubeau, Montreal Neurological Institute, McGill University, Montreal, QC, Canada

Jonathan Edwards, Medical University of South Carolina, Department of Neurology, Charleston, SC, USA

Jerome Engel, Jr., Departments of Neurology, Neurobiology, and Psychiatry & Biobehavioral Sciences and the Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

Stefano Francione, "Claudio Munari" Epilepsy Surgery Centre, Neuroscience Department, Niguarda Ca' Granda Hospital, Milan, Italy

Birgit Frauscher, Department of Medicine and Center for Neuroscience Studies, Queen's University, Kingston, ON, Canada

Itzhak Fried, Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

Greg A. Gerhardt, Department of Neuroscience, University of Kentucky College of Medicine, Lexington, KY, USA

Stephanie Gollwitzer, Epilepsy Center, Department of Neurology, University Hospital Erlangen, Erlangen, Germany

Jorge Gonzalez-Martinez, Epilepsy Center, The Cleveland Clinic Foundation, Cleveland, OH, USA

Jean Gotman, Montreal Neurological Institute, McGill University, Montreal, QC, Canada

Marc Guénot, Department of Functional Neurosurgery, P. Wertheimer Hospital, Lyon, France

Hajo M. Hamer, Epilepsy Center, Department of Neurology, University Hospital Erlangen, Erlangen, Germany

A. Simon Harvey, Department of Neurology, Royal Children's Hospital (Melbourne), Parkville, VIC, Australia

Edouard Hirsch, Medical and Surgical Epilepsy Unit, Hautepierre Hospital, University of Strasbourg, Strasbourg, France

Dominique Hoffmann, Neurology and Psychiatry Department, Grenoble University Hospital, Grenoble, France

Michelle L. Humeiden, Center for Microelectrode Technology, University of Kentucky College of Medicine, Lexington, KY, USA

Akio Ikeda, Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, Kyoto, Japan

Julia Jacobs, Department of Neuropediatrics and Muscular Disease, Epilepsy Center, University Medical Center Freiburg, Germany

Anne-Sophie Job-Chapron, Neurology and Psychiatry Department, Grenoble University Hospital, Grenoble, France

Pavel Jurák, Institute of Scientific Instruments, Academy of Sciences of the Czech Republic, Brno, Czech Republic

Philippe Kahane, Neurology and Psychiatry Department, Grenoble University Hospital, Grenoble, France

Michal T. Kucewicz, Department of Neurology, Mayo Clinic, Rochester, MN, USA; Multimedia Systems Department, Faculty of Electronics, Telecommunications and Informatics, Gdansk University of Technology, Gdansk, Poland

Takeharu Kunieda, Department of Neurosurgery, Graduate School of Medicine, Ehime University, Kyoto, Japan

Ekrem Kutluay, Medical University of South Carolina, Department of Neurology, Charleston, SC, USA

Jean-Philippe Lachaux, Lyon Neuroscience Research Center, Lyon, France

Nuria Lacuey, Department of Neurology, UH Case Medical Center, Cleveland OH, USA

Patrick Landazuri, Department of Neurology, University of Kansas Medical Center, Kansas City, MO, USA

Elisabeth Landré, Department of Neurosurgery, Sainte-Anne Hospital, Paris, France

Alexandra Liava, Neuroscience Department, University of Milan-Bicocca, Milan, Italy

Ronald P. Lesser, Johns Hopkins Hospital Epilepsy Center, Baltimore, MD, USA

Samden D. Lhatoo, Department of Neurology, UH Case Medical Center, Cleveland, OH, USA

Hans O. Lüders, Department of Neurology, UH Case Medical Center, Cleveland, OH, USA

Roberto Mai, "Claudio Munari" Epilepsy Surgery Centre, Niguarda Hospital, Milan, Italy

Louis Maillard, Department of Neurology, University Hospital of Nancy, Nancy, France

Riki Matsumoto, Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, Kyoto, Japan

Aileen McGoniga, Aix-Marseille University, Medical School, Marseille, France

Robert A. McGovern, Department of Neurological Surgery, The Neurological Institute, Columbia University Medical Center, New York, NY, USA

Guy M. McKhann II, Department of Neurological Surgery, The Neurological Institute, Columbia University Medical Center, New York, NY, USA

Jonathan P. Miller, Department of Neurological Surgery, UH Case Medical Center, Cleveland, OH, USA

Lorella Minotti, Neurology and Psychiatry Department, Grenoble University Hospital, Grenoble, France

Gholam K. Motamedi, Department of Neurology, Georgetown University Medical Center, Washington, DC, USA

Thomas Ostergard, Department of Neurological Surgery, UH Case Medical Center, Cleveland, OH, USA

Eliseu Paglioli, Neurosurgery Service, São Lucas Hospital, Porto Alegre, RS, Brazil

André Palmini, Neurology Service, São Lucas Hospital, Porto Alegre, RS, Brazil

Fabienne Picard, Department of Clinical Neurosciences, University Hospitals and Medical School of Geneva, Switzerland

Jorge E. Quintero, Department of Neuroscience, University of Kentucky College of Medicine, Lexington, KY, USA

Georgia Ramantani, Division of Child Neurology, University Children's Hospital, Zurich, Switzerland

Ivan Rektor, Masaryk University, Central European Institute of Technology - CEITEC, Neuroscience Centre and Movement Disorders Centre, Brno, Czech Republic

Felix Rosenow, Department of Neurology and Epilepsy Center, Frankfurt Rhine-Main Goethe University, Frankfurt, Germany

Philippe Ryvlin, Department of Clinical Neurosciences, Lausanne University Hospital, Lausanne, Switzerland

Americo C. Sakamoto, Epilepsy Center, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto-SP, Brazil

Stephan U. Schuele, Northwestern University, Feinberg School of Medicine, Department of Neurology, Chicago, IL, USA

Julia Scholly, Medical and Surgical Epilepsy Unit, Hautepierre Hospital, University of Strasbourg, Strasbourg, France

Catherine A. Scott, UCL Institute of Neurology, London, UK

John T. Slevin, Departments of Neurology and Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, KY, USA

Mathieu Sprengers, Department of Neurology, Ghent University Hospital, Ghent, Belgium

Richard Staba, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

Laura Tassi, "Claudio Munari" Epilepsy Surgery Centre, Niguarda Hospital, Milan, Italy

Vernon L. Towle, Department of Neurology, University of Chicago Medical Center, Chicago, IL, USA

Baris Turak, Department of Neurosurgery, Sainte-Anne Hospital, Paris, France

William A. Vandergrift, Medical University of South Carolina, Department of Neurology, Charleston, SC, USA

Tonicarlo R. Velasco, Epilepsy Center, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto-SP, Brazil

Kristl Vonck, Department of Neurology, Ghent University Hospital, Ghent, Belgium

Fabrice Wendling, Rennes University, Rennes, France

Gregory A. Worrell, Department of Neurology and Division of Epilepsy, Mayo Clinic, Rochester, MN, USA

Shasha Wu, Department of Neurology, University of Chicago Medical Center, Chicago, IL, USA

Invasive Studies of the Human Epileptic Brain

Principles and Practice

Edited by Samden D. Lhatoo, Philippe Kahane, and Hans O. Lüders

Reviews and Awards

"This is an extremely useful book for those seeking multidisciplinary knowledge of invasive epilepsy recording. Its comprehensiveness will prove useful for those seeking to better collaboration through mutual understanding. For those in clinical practice, the organization of topics will enable effective review in a clinically relevant manner." - Nealen G. Laxpati, Neurosurgery