Huntington's Disease
Fourth Edition
Edited by Gillian Bates, Sarah Tabrizi, and Lesley Jones
Author Information
Edited by Gillian Bates, Professor of Neurogenetics, Department of Medical and Molecular Genetics, King's College London, London, UK, Edited by Sarah Tabrizi, Professor of Clinical Neurology, Department of Neurodegenerative Disease, University College London, Institute of Neurology, London, UK, and Lesley Jones, Senior Lecturer in Neuropsychiatric Genetics, MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences School of Medicine, Cardiff University, Cardiff, UK
Professor Gillian Bates obtained her PhD from the University of London in 1987. Her postdoctoral work was conducted with Hans Lehrach at the ICRF on the cloning of the Huntington's disease gene. Her work has at the forefront of Huntington's disease research since establishing her independent research programme in 1994.
Professor Lesley Jones obtained her PhD from Cardiff University in 1990 and moved to the then University of Wales College of Medicine in 1994 to work on the biochemistry of huntingtin in HD. Her work has primarily been concerned with the notable downstream effects of mutant huntingtin on gene expression. She is also leading work on genetic modifiers of HD to assist in the identification of molecular pathways important in disease pathology.
Sarah Tabrizi is Professor of Clinical Neurology in the Department of Neurodegenerative Diseases at the UCL Institute of Neurology and Honorary Consultant Neurologist at the National Hospital of Neurology and Neurosurgery. Her research focuses on the pathobiological, translational and clinical aspects of neurodegeneration with a major focus on Huntington's disease. Sarah leads two major, international multidisciplinary research initiatives, TRACK-HD and Track-On HD, aimed at understanding the neurobiology of the neurodegenerative changes in premanifest and early stage HD gene carriers and identifying sensitive measures of disease progression.
Contributors:
N. Ahmad Aziz
Department of Neurology
Leiden University Medical Center
Leiden, The Netherlands
Véronique M. André, Ph.D.
Intellectual and Developmental Disabilities Research Center,
Semel Institute for Neuroscience and Human Behavior and the Brain Research Institute,
David Geffen School of Medicine
University of California Los Angeles
Los Angeles, California
Gillian P. Bates
Department of Medical and Molecular Genetics
King's College London
London, United Kingdom
Maria Björkqvist
Neuronal Survival Unit
Department of Experimental Medical Science
Wallenberg Neuroscience Center
Lund University
Lund, Sweden
Beth Borowsky, PhD
Department of Clinical Research
CHDI Foundation, Inc.
Princeton, New Jersey
Elena Cattaneo, PhD
Department of BioSciences and Centre for Stem Cell Research
Università degli Studi di Milano
Milano, Italy
Dr. David Craufurd
University of Manchester, Manchester Academic Health Science Centre & Central Manchester University Hospitals NHS Foundation Trust
Genetic Medicine
St Mary's Hospital
Manchester
Alexandra Durr, MD, PhD
Hôpital de la Salpêtrière, Departement of Genetics and Cytogenetics,
Fonctional Unit of Molecular and Cellular Neurogenetics;
Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière,
Université Pierre et Marie Curie-Paris6,
Paris, France
Cécile Cazeneuve, PharmD, PhD
Hôpital de la Salpêtrière, Departement of Genetics and Cytogenetics,
Fonctional Unit of Molecular and Cellular Neurogenetics
Paris, France
Carlos Cepeda, Ph.D.
Intellectual and Developmental Disabilities Research Center,
Semel Institute for Neuroscience and Human Behavior and the Brain Research Institute,
David Geffen School of Medicine
University of California Los Angeles
Los Angeles, California
Jane Y. Chen, B.A.
Intellectual and Developmental Disabilities Research Center,
Semel Institute for Neuroscience and Human Behavior and the Brain Research Institute,
David Geffen School of Medicine
University of California Los Angeles
Los Angeles, California
Richard LM Faull
Centre for Brain Research and Departments of Anatomy with Radiology
University of Auckland
Auckland, New Zealand
Emily Fisher, MSc, BSc
Centre for Molecular Medicine and Therapeutics
Child and Family Research Institute
University of British Columbia
Vancouver, BC, Canada
Peter S. Harper
Institute of Medical Genetics
University of Wales College of Medicine
Cardiff, United Kingdom
Michael R. Hayden, CM, OBC, MB, ChB, PhD, FRCP (C), FRSC
Centre for Molecular Medicine and Therapeutics
Child and Family Research Institute
University of British Columbia
Vancouver, Canada
Alis Hughes
MRC Centre for Neuropsychiatric Genetics and Genomics
Institute of Psychological Medicine and Clinical Neurosciences
School of Medicine
Cardiff University
Cardiff, United Kingdom
Lesley Jones
MRC Centre for Neuropsychiatric Genetics and Genomics
Institute of Psychological Medicine and Clinical Neurosciences
School of Medicine
Cardiff University
Cardiff, United Kingdom
Chris Kay, BSc, BA
Centre for Molecular Medicine and Therapeutics
Child and Family Research Institute
University of British Columbia
Vancouver, BC, Canada
Eric H Kim
Centre for Brain Research and Departments of Anatomy with Radiology
University of Auckland
Auckland, New Zealand
Christian Landles
Department of Medical and Molecular Genetics
King's College London
London, United Kingdom
Michael S. Levine, Ph.D.
Intellectual and Developmental Disabilities Research Center,
Semel Institute for Neuroscience and Human Behavior and the Brain Research Institute,
David Geffen School of Medicine
University of California Los Angeles
Los Angeles, California
Rhona MacLeod
Genetic Medicine
Manchester Academic Health Science Center
Central Manchester university hospitals NHS Foundation Trust
Manchester, United Kingdom
Rakesh Mishra, PhD
Department of Structural Biology and Pittsburgh Institute for Neurodegenerative Diseases
University of Pittsburgh School of Medicine
Pittsburgh, PA
Martha A. Nance, MD
Department of Neurology
University of Minnesota
Minneapolis, MN
Oliver W J Quarrell, BSc MD FRCP
Consultant in Clinical Genetics
Dept Clinical Genetics
Sheffield Children's Hospital
Sheffield UK
Raymund AC Roos, MD
Dept Neurology K5Q112
LUMC
Postbus 9600
2300RC Leiden
The Netherlands
Cristina Sampaio, MD, PhD
Department of Clinical Research
CHDI Foundation, Inc.
Princeton, New Jersey
Prof. Julie S Snowden
Manchester Academic Health Sciences Centre (MAHSC)
Cerebral Function Unit, Clinical Neurosciences
Salford Royal Foundation Trust
Salford
Prof Sarah J Tabrizi FRCP PhD
Department of Neurodegenerative Disease
University College London, Institute of Neurology
London, United Kingdom
Aad Tibben, PhD
Department of Clinical Genetics
Leiden University Medical Center
Leiden, The Netherlands
Lynette J Tippett
Centre for Brain Research and Department of Psychology
University of Auckland
Auckland, New Zealand
Jorien M.M. van der Burg
Neuronal Survival Unit
Department of Experimental Medical Science
Wallenberg Neuroscience Center
Lund University
Lund, Sweden
Jean-Paul G Vonsattel
Department of Pathology
Presbyterian Hospital; and
Columbia University
New York, NY
Henry J Waldvogel
Centre for Brain Research and Departments of Anatomy with Radiology
University of Auckland
Auckland, New Zealand
Elizabeth A. Wang, B.A.
Intellectual and Developmental Disabilities Research Center,
Semel Institute for Neuroscience and Human Behavior and the Brain Research Institute,
David Geffen School of Medicine
University of California Los Angeles
Los Angeles, California
Ronald Wetzel, PhD
Department of Structural Biology and Pittsburgh Institute for Neurodegenerative Diseases
University of Pittsburgh School of Medicine
Pittsburgh, PA
Dr Edward J Wild MRCP PhD
Department of Neurodegenerative Disease
University College London, Institute of Neurology
London, United Kingdom
Chiara Zuccato, PhD
Department of BioSciences and Centre for Stem Cell Research
Università degli Studi di Milano
Milano, Italy
