Human Cytogenetics

A Practical Approach

Third Edition

Volume 1: Constitutional Analysis

Edited by D. E. Rooney

Human Cytogenetics

A Practical Approach

Third Edition

Volume 1: Constitutional Analysis

Edited by D. E. Rooney

Description

Human Cytogenetics: Constitutional Analysis covers all basic aspects of human cytogenetic study other than malignancies and abnormalities. They are covered in a separate volume. Since the publication of the 2nd edition in 1992, there have been major advances in technology and the emphasis of this new edition is on the spectrum of technologies available to conventional and molecular cytogenetics. Perhaps the largest new development has been the transition of fluorescence in situ hybridization to an essential tool for all cytogenetecists and consequently its use in chromosome analysis is covered in detail. Another important new technology to be described in detail is computerised image analysis. The conventional techniques have not been forgotten, with chapters on chromosome staining and banding techniques and meiotic studies. New authors have been brought in to take a fresh look at lymphocyte culture and prenatal diagnosis. As before, there is an introduction to human chromosomes, their analyses, and the application of cytogenetic investigations to clinical practice. There is also an appendix on health and safety concerns in the cytogenetics laboratory. This book will be invaluable to any scientists using basic cytogenetics and along with its sister volume Human Cytogenetics: Malignancy and Acquired Abnormalities will be an essential purchase for any cytogenetics laboratory. The volumes are available individually or as a set.

Human Cytogenetics

A Practical Approach

Third Edition

Volume 1: Constitutional Analysis

Edited by D. E. Rooney

Practical Approach Series

Preface
List of protocols
Abbreviations
1. An introduction to human chromosomes and their analysis, I. Cross and J. Wolstenholme
2. Lymphocyte culture, Hazel J. Clouston
3. The cytogenetics of pregnancy, Tracy Boyle and Darren Griffin
4. Chromosome staining and banding techniques, P. A. Benn and U. Tantravahi
5. The application of cytogenetic investigations to clinical practice, J. Wolstenholme and J. Burn
6. The application of fluorescence in situ hybridization to chromosome analysis, Lyndal Kearney and Veronica J. Buckle
7. Meiotic studies in humans, M. A. Hultn, A. L. Barlow, and C. Tease
8. Microscopy and image analysis systems, E. R. Levy and E. J. Maher
Appendix 1: List of suppliers
Appendix 2: Safety considerations
Appendix 3: Chromosomes
Index

Human Cytogenetics

A Practical Approach

Third Edition

Volume 1: Constitutional Analysis

Edited by D. E. Rooney

Practical Approach Series

Author Information

Contributors:

I. E.Cross, J. Wolstenholme, H. J. Clouston, T. Boyle, D. Griffin, P.A. Benn, U. Tantravahi, J. Wolstenholme, J. Burn, L.U. Kearney, V.J. Buckle, M. A. Hulten

Human Cytogenetics

A Practical Approach

Third Edition

Volume 1: Constitutional Analysis

Edited by D. E. Rooney

Practical Approach Series

Reviews and Awards

"All cytogeneticists, and especially researchers and trainees, would benefit from the expert general knowledge of cytogenetics that is imparted via these books . . . high quality of the written content . . . both books would be invaluable to any cytogenetics laboratory, wherever their interest lies."--Heredity