Homeostatic Control of Brain Function

Edited by Detlev Boison and Susan A. Masino

A focus on the homeostatic controls that significantly depend on the way one lives, eats, and drinks.
Highlights from emerging research in non-pharmaceutical therapies including botanical medications, meditation, diet, and exercise.
Extensive scientific basic and clinical research ranging from molecules to disorders.
Emerging practical information for improving homeostasis.
Examples of homeostatic therapies in preventing and delaying dysfunction.

Homeostatic Control of Brain Function

Edited by Detlev Boison and Susan A. Masino

Description

Homeostatic Control of Brain Function offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss of homeostasis becomes expressed as a diverse array of neurological disorders.

Each disorder has multiple comorbidities - with some crossing over several conditions - and often disease-specific treatments remain elusive. When current pharmacological therapies result in ineffective and inadequate outcomes, therapies to restore and maintain homeostatic functions can help improve brain health, no matter the diagnosis. Employing homeostatic therapies may lead to future cures or treatments that address multiple comorbidities. In an age where brain diseases such as Alzheimer's or Parkinson's are ever present, the incorporation of homeostatic techniques could successfully promote better overall brain health.

Key Features include
· A focus on the homeostatic controls that significantly depend on the way one lives, eats, and drinks.
· Highlights from emerging research in non-pharmaceutical therapies including botanical medications, meditation, diet, and exercise.
· Incorporation of homeostatic therapies into existing basic and clinical research paradigms.
· Extensive scientific basic and clinical research ranging from molecules to disorders.
· Emerging practical information for improving homeostasis.
· Examples of homeostatic therapies in preventing and delaying dysfunction.

Both editors, Detlev Boison and Susan Masino, bring their unique expertise in homeostatic research to the overall scope of this work. This book is accessible to all with an interest in brain health; scientist, clinician, student, and lay reader alike.

Homeostatic Control of Brain Function

Edited by Detlev Boison and Susan A. Masino

Prologue
Part I: Homeostatic Regulators: Molecules and Ions
Chapter 1: Microdynamics of water and ion homeostasis in the brain: role of aquaporins and ion channels of astroglial cells
Chapter 2: Homeostatic control of adenosine levels and functions in brain
Chapter 3: Glutamate homeostasis as a regulatory of neurotransmitter recycling and synaptic function)
Chapter 4: Homeostasis of neuronal excitability via synaptic and intrinsic inhibitory mechanisms
Part II: Homeostatic Control: Systems, Cells and Organelles
Chapter 5: Role of astrocytes in sleep and epilepsy
Chapter 6: Neuron-astrocyte interactions
Chapter 7: Homeostatic synaptic scaling at central synapses
Chapter 8: Homeostatic role of heterosynaptic plasticity
Chapter 9: The Blood Brain Barrier
Chapter 10: Inflammation and immunomodulation in epilepsy and its comorbidities
Chapter 11: Neuroplasticity
Chapter 12: Epigenetics
Chapter 13: Adult neural stem cells and brain homeostasis
Part III: Homeostatic Manipulators: Preventative and Restorative Opportunities
Chapter 14: Systems (network) pharmacology for brain functionality restoration
Chapter 15: Ketogenic diets, mitochondria, and neurological diseases
Chapter 16: Dietary manipulations
Chapter 17: Exercise
Chapter 18: Sleep
Chapter 19: Botanicals
Chapter 20: The role of acupuncture in nociception homeostasis
Chapter 21: Meditation
Chapter 22: Neurotrophic regulation in neurorestoration of brain
Part IV: Homeostatic Therapies for Disease and Dysfunction
Chapter 23: Epilepsy
Chapter 24: Traumatic Brain Injury
Chapter 25: Adenosine and Alzheimer's Disease, a possible epigenetic link
Chapter 26: Brain homeostasis and Parkinson's Disease
Chapter 27: Brain homeostasis and addiction
Chapter 28: Anxiety and stress disorders
Chapter 29: Malignant brain cancer management with metabolic therapy
Chapter 30: Obesity and diabetes: Nature, nurture, and beyond
Chapter 31: Autism spectrum disorders and homeostasis

Homeostatic Control of Brain Function

Edited by Detlev Boison and Susan A. Masino

Author Information

Edited by Detlev Boison, PhD, Legacy Research Institute, and Edited by Susan A. Masino, PhD, Trinity College

Detlev Boison is the Robert Stone Dow Chair of Neurology; the Director of Neurobiology Research; and the Director of Basic and Translational Research at the Legacy Research Institute

Susan A. Masino is the Vernon Roosa Professor of Applied Science; and a Professor of Neuroscience and Psychology at Trinity College

Contributors:

Nicholas M. Bannon
Department of Psychology
University of Connecticut
Storrs, CT

Valentina Benfenati
Istituto per lo Sintesi Organica e Fotoreattività
ISOF
National Research Council (CNR)
Bologna, Italy

David Blum,
Inserm
Université de Lille
Jean-Pierre Aubert Research Centre
Institut de Médecine Prédictive et de Recherche Thérapeutique
CHRU-Lille,
Lille, France

Ingmar Blumcke
Department of Neuropathology
University Hospital Erlangen
Erlangen, Germany

Olivier Bousiges,
Laboratoire de Neurosciences Cognitives et Adaptatives (LNCA)
Université de Strasbourg
Strasbourg, France

Anne-Laurence Boutillier,
Laboratoire de Neurosciences Cognitives et Adaptatives (LNCA)
Université de Strasbourg,
Strasbourg, France

Angus M. Brown
Department of Neurology
University of Washington
Seattle, WA
School of Life Sciences
University of Nottingham
Nottingham, England
UK
Luc Buée
Inserm,
Lille, France
Université de Lille
Jean-Pierre Aubert Research Centre
Institut de Médecine Prédictive et de Recherche Thérapeutique
CHRU-Lille,
Lille, France

Xuesong Chen
Department of Basic Biomedical Sciences
University of North Dakota School of Medicine and Health Sciences
Grand Forks, ND

Marina Chistiakova
Department of Psychology
University of Connecticut
Storrs, CT

Jerome Clasadonte
Department of Neuroscience
Tufts University School of Medicine
Boston, MA

Douglas A. Coulter
Departments of Pediatrics and Neuroscience
Perleman School of Medicine
University of Pennsylvania and the Division of Neurology
Children's Hospital of Philadelphia
Philadelphia, PA

Niraj S. Desai
Center for Learning and Memory
The University of Texas at Austin
Austin, TX

Gaëlle Desbordes, PhD
Markus Dworak, PhD
Dana Ekstein
Athanasios Evangeliou, MD
Emilie Faivre
Inserm,
Lille, France
Université de Lille
Jean-Pierre Aubert Research Centre
Institut de Médecine Prédictive et de Recherche Thérapeutique
CHRU-Lille,
Lille, France

Stefano Ferroni
Department of Pharmacy and Biotechnology
University of Bologna
Bologna, Italy

Vanessa Flaten
Inserm,
Lille, France
Université de Lille
Jean-Pierre Aubert Research Centre
Institut de Médecine Prédictive et de Recherche Thérapeutique
CHRU-Lille,
Lille, France

Jessica A. Fortin
Neuroscience Program
Trinity College
Hartford, CT

Alon Friedman
Department of Physiology and Cell Biology
Zlotowski Center for Neuroscience
Ben-Gurion University of the Negev
Beer-Sheva, Israel
Department of cognitive and brain sciences
Zlotowski Center for Neuroscience
Ben-Gurion University of the Negev
Beer-Sheva, Israel

Lindsey B. Gano
Department of Pharmaceutical Sciences
School of Pharmacy
University of Colorado
Denver, Colorado

Jonathan D. Geiger
Department of Basic Biomedical Sciences
University of North Dakota School of Medicine and Health Sciences
Grand Forks, ND

Nanna Goldman
Center for Translational Neuromedicine
University of Rochester Medical Center
Rochester, NY

Philip G. Haydon
Annetta and Gustav Grisard Professor and Chair
Department of Neuroscience
Tufts University School of Medicine
Boston, MA

Uwe Heinemann
Institute of Neurophysiology and Neurocure Research Center
Charité Universitätsmedizin
Berlin, Germany

Liang Hui
Department of Basic Biomedical Sciences
University of North Dakota School of Medicine and Health Sciences
Grand Forks, ND

Shucui Jiang
Department of Surgery (Neurosurgery, Neurobiology)
Hamilton NeuroRestorative Group (NRG)
McMaster University
Health Sciences Centre
Hamilton, ON
Canada
Chaz Johnson

Mary Ellen Kelly
Departments of Pediatrics and Neuroscience
Perleman School of Medicine
University of Pennsylvania and the Division of Neurology
Children's Hospital of Philadelphia
Philadelphia, PA

Katja Kobow
Department of Neuropathology
University Hospital Erlangen
Erlangen, Germany

Benjamin Kress
Center for Translational Neuromedicine
University of Rochester Medical Center
Rochester, NY

Raj G. Kumar, MPH
Deepti Lall, PhD
Luisa V. Lopes,
Instituto de Medicina Molecular
Lisbon, Portugal

Eva María Marco
Departamento de Fisiología (Fisiología Animal II)
Facultad de Biología
Universidad Complutense,
Ciudad Universitaria,
Madrid, Spain

Doru Georg Margineanu
Department of Neurosciences
Medicine and Pharmacy
University of Mons,
Mons, Belgium

Andrey Mazarati
Department of Pediatrics
Children's Discovery and Innovation Institute.
David Geffen School of Medicine
UCLA
Los Angeles, CA

Jochen Meier
Max Delbrück Center for Molecular Medicine
Berlin, Germany

Charles Mobbs, PhD,
Professor
Neuroscience, Endocrinology, and Geriatrics
Mount Sinai School of Medicine
New York, New York

Purna Mukherjee
Biology Department
Chestnut Hill, MA

Michelle I. Murphy
Neuroscience Program
Trinity College
Hartford, CT

Maiken Nedergaard
Center for Translational Neuromedicine
University of Rochester Medical Center
Rochester, NY

Hiroyuki Okuno
Medical Innovation Center
Graduate School of Medicine
Kyoto University
Kyoto, Japan

Manisha Patel
Department of Pharmaceutical Sciences
School of Pharmacy
University of Colorado
Denver, Colorado

Bruce R. Ransom
Department of Neurology
University of Washington
Seattle, WA

Michel Rathbone
Department of Medicine (Neurology, Neuroscience
Hamilton NeuroRestorative Group (NRG)
McMaster University
Health Sciences Centre
Hamilton, ON
Canada

Jong M. Rho
Faculty of Medicine
Departments of Pediatrics and Clinical Neurosciences
Alberta Children's Hospital Research Institute for Child and Maternal Health
University of Calgary
Calgary, Alberta
Canada

Harrison Roundtree

David N. Ruskin
Neuroscience Program,
Psychology Department,
Trinity College,
Hartford, CT

Lisa Saa
Neuroscience Program
Trinity College
Hartford, CT

Kaeli Samson

Ursula Sandau,
Legacy Research Institute
Portland, OR

Steven C. Schachter

Marcus Semtner
Max Delbrück Center for Molecular Medicine
Berlin, Germany

Yonatan Serlin
Department of Physiology and Cell Biology
Zlotowski Center for Neuroscience
Ben-Gurion University of the Negev
Beer-Sheva, Israel

Thomas N. Seyfried
Biology Department
Chestnut Hill, MA

Ashok K. Shetty, M.Sc., Ph.D.
Professor and Director of Neurosciences
Institute for Regenerative Medicine
Texas A&M Health Science Center College of Medicine at Scott and White
Temple, Texas
Research Service
Olin E. Teague Veterans' Medical Center
Central Texas Veterans Health care System
Temple, Texas
Department of Molecular and Cellular Medicine
Texas A&M Health Science Center College of Medicine
College Station, Texas

Kristina Simeone
Tim Simeone

Mahmoud L. Soliman
Department of Basic Biomedical Sciences
University of North Dakota School of Medicine and Health Sciences
Grand Forks, ND

Martha Spilioti, MD

Caixin Su
Department of Surgery (Neurosurgery, Neurobiology)
Hamilton NeuroRestorative Group (NRG)
McMaster University
Health Sciences Centre
Hamilton, ON
Canada

Takahiro Takano
Center for Translational Neuromedicine
University of Rochester Medical Center
Rochester, NY

Leila Tarokh

Annamaria Vezzani
IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri "
Milano, Italy

María-Paz Viveros
Departamento de Fisiología (Fisiología Animal II)
Facultad de Biología
Universidad Complutense,
Ciudad Universitaria,
Madrid, Spain

Maxim Volgushev
Department of Psychology
University of Connecticut
Storrs, CT

Amy K. Wagner, MD
Associate Professor
Physical Medicine and Rehabilitation
University of Pittsburgh
Pittsburgh, PA

Elisabeth C. Walcott
Department of Psychological Sciences
University of San Diego
San Diego, CA

Jakob Wolfart
Oscar Langendorff Institute of Physiology
University of Rostock
Rostock, Mecklenburg-Vorpommern
Germany

Letisha R. Wyatt, PhD
R.S. Dow Neurobiology Laboratories
Legacy Research Institute
Portland, OR

Homeostatic Control of Brain Function

Edited by Detlev Boison and Susan A. Masino

Reviews and Awards

"Homeostatic Control of Brain Function is a serious resource for scientists at all levels. While outlining detailed mechanisms several dozen experts in the field consider how basic principles of homeostasis influence brain function from molecules to behavior. Accordingly, Homeostatic Control of Brain Function offers insights into why and how to restore homeostasis therapeutically, and perhaps non-pharmacologically. One of the most interesting aspects is up-to-date scientific information underling beneficial and available therapies such as meditation and acupuncture. In sum, Boison and Masino have organized a provocative and forward-looking book as we continue to grapple with new insights and develop therapies for complex and overlapping brain diseases." - Paul Lombroso, MD, Professor and Deputy Chair of Research, Child Study Center and Departments of Psychiatry and Neurobiology, Yale University School of Medicine