Genomic Medicine

Edited by Dhavendra Kumar, Consultant in Clinical Genetics, Institute of Medical Genetics, Cardiff University, and Edited by Charis Eng, Hardis Chair and Director of the Genomic Medicine Institute, Director of the Center for Personalized Genetic Healthcare

Professor Dhavendra Kumar, MD, FRCP, FACM, Consultant in Clinical Genetics, Institute of Medical Genetics (Cardiff University), Genomic Policy Unit (University of Glamorgan), University Hospital of Wales, Cardiff University, Cardiff, UK

Professor Charis Eng, MD, PhD, FACP, ACS/Hardis Professor and Chairwoman of the Genomic Medicine Institute and Director of the Center for Personalized Genetic Healthcare, The Cleveland Clinic, Ohio, USA; Professor and Vice Chair of the Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, USA

Black, Graeme Charles, PhD FRCOphth
Manchester Centre for Genomic Medicine,Institute of Human Development?University of Manchester?and?Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre (MAHSC),
St. Mary's Hospital,
Manchester, UK

Clarke, Angus John, DM FRCPCH
Institute of Medical Genetics
University Hospital of Wales
Cardiff University School of Medicine
Cardiff, UK
Panda, Binay, PhD
Ganit Labs, Bio-IT Centre,
Institute of Bioinformatics and Applied Biotechnology,
Bangalore, India

Krishnan, Neerja M, PhD
Strand Life Sciences,
Bangalore, India

McAllister, Kate, PhD
Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, Institute of Inflammation and Repair and NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, The University of Manchester, UK

Eyre, Stephen
Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, Institute of Inflammation and Repair & NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Stopford Building, The University of Manchester, UK

Loh, Kyle M., PhD
Stanford University School of Medicine,
Department of Developmental Biology
The Stanford Institute for Stem Cell Biology and Regenerative Medicine,
Stanford, CA USA

Lim, Bing, PhD
Genome Institute of Singapore, Stem Cell & Developmental Biology Group, Singapore
Harvard Medical School, Department of Medicine and the Beth Israel Deaconess Medical Center,
Department of Hematology/Oncology, Boston, MA

Ang, Lay Teng, PhD
Genome Institute of Singapore,
Stem Cell & Developmental Biology Group,
Singapore

Kleinman, Mark E., MD
Departments of Ophthalmology & Visual Sciences and Physiology,
University of Kentucky,
Lexington, USA

Ambati, Jayakrishna, MD
Departments of Ophthalmology & Visual Sciences and Physiology,
University of Kentucky,
Lexington, USA

Ngeow, Joanne, MBBS, MRCP
Genomic Medicine Institute and Lerner Research Institute
Cleveland Clinic,
Cleveland, Ohio

Rötig, Agnés
INSERM U781,
Hôpital Necker-Enfants Malades,
Université Paris Descartes,
Paris, France

Healy, Eugene
Department of Dermatology
School of Medicine
The University of Southampton
Southampton, UK

Kaye, Jane, DPhil
The ETHOX
Department of Public Health
The University of Oxford
The Churchill Hospital
Headington,
Oxford, UK

Fan, Jinbo, PhD
Departments of Epidemiology and Biostatistics AND Psychiatry
Case Western Reserve University School of Medicine
Cleveland, OH

Morrissey, Brian
UCD Conway Institute, School of Medicine and Medical Science,
University College Dublin,
Belfield,
Dublin 4, Ireland

Staunton, Lisa
University College Dublin Conway Institute,
School of Medicine and Medical Science,
Belfield,
Dublin 4, Ireland

Pennington, Stephen R.
University College Dublin Conway Institute,
School of Medicine and Medical Science,
Belfield,
Dublin 4, Ireland

Kumar, Dhavendra, MD FRCP FACMG
Institutes of Cancer & Genetics & Molecular and Experimental Medicine,
Cardiff University School of Medicine,
University Hospital of Wales, Cardiff
and
Genomic Policy Unit,
The Faculty of Life Sciences & Education
The University of South Wales,
Pontypridd, UK

Eng, Charis, MD PhD
Genomic Medicine Institute
Center for Personalized Genetic Healthcare
Cleveland Clinic & Lerner College of Medicine
Case Western Reserve University School of Medicine
Cleveland, Ohio
USA

Ong, Albert C.M, DM FRCP
Academic Nephrology Unit,
University of Sheffield Medical School
Sheffield Kidney Institute,
Sheffield Teaching Hospitals NHS Foundation Trust,
Sheffield, UK

Maxwell, Alexander P., FRCP
Regional Nephrology Unit,
Belfast City Hospital,
Queens University,
Belfast, UK

Yamada, Yoshiji, MD, PhD
Department of Human Functional Genomics,
Life Science Research Center,
Mie University,
Tsu,
Japan

Sadee, Wolfgang, Dr.rer.nat.
Department of Psychiatry, Division of Medical Genetics, and Department of Pharmacology
College of Medicine
The Ohio State University
Columbus OH

Raymond, F Lucy, FRCP PhD
Department of Medical Genetics
Addenbrooke's Hospital,
Hill Road,
Cambridge,
England, UK

Fakiola, Michaela, PhD
Cambridge Institute for Medical Research,
Addenbrookes Hospital,
Hills Road,
Cambridge, UK

Lu, Wei, PhD
School of Pathology and Laboratory Medicine,
Faculty of Medicine and Dentistry,
The University of Western Australia,
Nedlands, Western Australia.

Jamieson, Saara E., PhD
Telethon Institute for Child Health Research,
Centre for Child Health Research,
University of Western Australia,
Subiaco, Western Australia.

Peacock, Christopher S., PhD
School of Pathology and Laboratory Medicine,
Faculty of Medicine and Dentistry,
The University of Western Australia,
Nedlands, Western Australia.
and
Telethon Institute for Child Health Research,
Centre for Child Health Research,
The University of Western Australia,
Subiaco, Western Australia

McVey, John H., PhD, FRCP
MRC Centre for Transplantation,
Innate Immunity Section,
King's College London, Guy's Hospital,
London,
UK

Weatherall, Sir David J., DM FRCP
Weatherall Institute of Molecular Medicine
University of Oxford
John Radcliffe Hospital
Headington, Oxford, UK

Sharafieh, Roshanak, Ph.D.
Molecular Ophthalmic Genetics Laboratory,
University of Connecticut Health Center,
Farmington, CT

Child, Anne H., M.D.
Department of Cardiovascular Medicine
St. George's Hospital Medical School & Hospital,
Tooting
London, UK

Sarfarazi, Mansoor, Ph.D.
Molecular Ophthalmic Genetics Laboratory,
University of Connecticut Health Center,
Farmington, CT

Pyeritz, Reed E., MD, PhD
Departments of Medicine and Genetics
Perelman School of Medicine
The University of Pennsylvania
Philadelphia, PA

Read, Andrew P., PhD, FMedSci
Department of Genetic Medicine,
University of Manchester,
St Mary's Hospital
Hathersage Road
Manchester, UK

Pickrell, William Owen, MRCP, MEng
Clinical Research Fellow
Neurology and Molecular Neuroscience,
College of Medicine,
Institute of Life Science,
Swansea University
UK

Ramesh, Aravind,
Gene Control Mechanisms and Disease Group,
Department of Medicine,
Hammersmith Hospital,
London, UK

Yandim, Cihangir,
Gene Control Mechanisms and Disease Group,
Department of Medicine,
Hammersmith Hospital,
London, UK

Natisvili, Theona,
Gene Control Mechanisms and Disease Group,
Department of Medicine,
Hammersmith Hospital,
London, UK

Mauri, Marta,
Gene Control Mechanisms and Disease Group,
Department of Medicine,
Hammersmith Hospital,
London, UK

Law, Piu Pik,
Gene Control Mechanisms and Disease Group,
Department of Medicine,
Hammersmith Hospital,
London, UK

Chan , Jackson, P.K.
Gene Control Mechanisms and Disease Group,
Department of Medicine,
Hammersmith Hospital,
London, UK

Lewis, Santiago Uribe,
Gene Control Mechanisms and Disease Group,
Department of Medicine,
Hammersmith Hospital,
London, UK

Festenstein, Richard, MD
Gene Control Mechanisms and Disease Group,
Department of Medicine,
Hammersmith Hospital,
London,

Wright, Caroline F., PhD
Wellcome Trust Sanger Institute,
Wellcome Trust Genome Campus,
Hinxton, Cambridge UK,
The Ethox Centre, Department of Public Health,
University of Oxford,
Old Road Campus,
Oxford UK

Middleton, Anna, PhD
Wellcome Trust Sanger Institute,
Wellcome Trust Genome Campus,
Hinxton,
Cambridge UK

Parker, Michael, DPhil
The Ethox Centre, Department of Public Health,
University of Oxford,
Old Road Campus,
Oxford UK


Ashar, Foram, BS
McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University School of Medicine,
Baltimore, MD

Arking, Dan E, PhD
McKusick-Nathans Institute of Genetic Medicine,
Johns Hopkins University School of Medicine,
Baltimore, MD

Matthew C Frise, BA BM BCh MRCP
Specialty Registrar in General Internal Medicine and Intensive Care Medicine
Oxford University Hospitals NHS Trust
John Radcliffe Hospital
Oxford
UK

Charles Hinds, MBBS FRCP FRCA
Professor of Intensive Care Medicine
West Smithfield,
London
UK

Julian C Knight, BA MBChB DPhil FRCP
Senior Clinical Research Fellow in Genomic Medicine
Wellcome Trust Centre for Human Genetics
University of Oxford
Oxford
UK

Madore, Steven J., Ph.D.
Coriell Institute for Medical Research
Camden, NJ


Margarit, Immaculada, PhD
Novartis Vaccines and Diagnostics,
Via Fiorentina 1,
53100, Siena,
Italy

Mills, Kenneth, PhD
Professor of Experimental Haematology
Centre for Cancer Research and Cell Biology (CCRCB)
Queen's University Belfast
Belfast
Northern Ireland
UK

Pathan, Saad, MD
Senior Consultant
Qatar Biomedical Research Institute,
Qatar Foundation,
Qatar

Rappuoli, Rino, PhD
Novartis Vaccines and Diagnostics,
Via Fiorentina 1,
53100, Siena,
Italy

Gerrish, Amy, PhD
Research Assistant
MRC Centre for Neuropsychiatric Genetics & Genomics
Cardiff University School of Medicine
University Hospital of Wales
Cardiff, UK

Sims, Rebecca, PhD
Research Assistant
MRC Centre for Neuropsychiatric Genetics & Genomics
Cardiff University School of Medicine
University Hospital of Wales
Cardiff, UK

Williams, Julie, PhD
Co-Director/ Professor
MRC Centre for Neuropsychiatric Genetics & Genomics
Cardiff University School of Medicine
University Hospital of Wales
Cardiff, UK

Wise, Anastasia L., Ph.D.
National Human Genome Research Institute,
National Institutes of Health,
Bethesda, MD

Manolio, Teri A., M.D., Ph.D.
National Human Genome Research Institute,
National Institutes of Health,
Bethesda, MD

Harding, Katharine, MRCP
Institute of Psychological Medicine and Clinical Neuroscience,
Cardiff University School of Medicine,
University Hospital of Wales,
Heath Park, Cardiff
United Kingdom

Robertson, Neil, DM, FRCP
Institute of Psychological Medicine and Clinical Neuroscience,
Cardiff University School of Medicine, University Hospital of Wales,
Heath Park, Cardiff
United Kingdom

Ye, Kaixiong
Cornell University
Division of Nutritional Sciences
Ithaca, NY

Stover, Patrick J., PhD
Cornell University
Division of Nutritional Sciences
Ithaca, NY

Gu, Zhenglong, PhD
Division of Nutritional Sciences
Cornell University
Ithaca, NY

"Genomics and Clinical Medicine is the first textbook to comprehensively examine Medicine, especially pathophysiology and pathogenesis, through the lens of genomics." - JAMA

"...written by an equally outstanding roaster of authors, deal with all aspects of Genomic Medicine. The book combines general principles, and specific aspects of clinical practice, all in the light of genome analysis and the current laboratory methodologies."" - Stylianos E. Antonarakis, Professor and Chairman of Genetic Medicine, University of Geneva, President of Human Genome Organization, Geneva, Switzerland

"...most physicians have had little or no training in genetics or genomics, and will be hard pressed to quickly acquire the scientific principles, the medical knowledge, and the psychosocial skills that will be necessary for the successful introduction of genomic medicine. Busy practitioners will desperately need an authoritative source of information that includes both principles and specific applications. The introduction of this textbook, with its distinguished and authoritative list of contributors, thus arrives in the nick of time. Welcome to the genome era." - Francis S. Collins, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA

"...the book is a nice overview of developments in different fields of genomic medicine, written by a number of experts who give a thorough description of their argument." - European Journal of Human Genetics

"Genomics and Clinical Medicine could be used during the first or second year of medical school to provide an underpinning of genomics as a unifying theme to the diverse array of topics that are typically taught at this time." - New England Journal of Medicine

"This is a pioneering work of two doctors who as editors, have undertaken a monumental project, compiling a lot of relatively new knowledge put on paper by a total 50 pioneers in genomic medicine. All the authors and Drs. Kumar and Eng are to be congratulated for this unique, massive contribution to better understanding of disease so that eventually, millions of people can benefit from their work, to lead healthier lives." - Biz India Book Review