From Development to Degeneration and Regeneration of the Nervous System

Charles E. Ribak PhD, Carlos Aramburo de la Hoz Phd, Edward G. Jones, PhD, Jorge A. Larriva Sahd, PhD, and Larry W. Swanson PhD

From Development to Degeneration and Regeneration of the Nervous System

Charles E. Ribak PhD, Carlos Aramburo de la Hoz Phd, Edward G. Jones, PhD, Jorge A. Larriva Sahd, PhD, and Larry W. Swanson PhD

Description

This book provides current information about the three areas mentioned in the title: Neuronal Migration and Development, Degenerative Brain Diseases, and Neural Plasticity and Regeneration. The chapters about brain development examine the cellular and molecular mechanisms by which neurons are generated from the ventricular zone in the forebrain and migrate to their destinations in the cerebral cortext. This description of cortical development also includes a discussions of the Cajal-Retzius cell. Another chapter provides insight about the development of another forebrain region, the hypothalamus. The remaining chapters of this section examine the clinical relevance of brain development in certain disease states in humans: neural tube defects and the normal and abnormal development of human electroencephalographic recordings during the first year of age.

The second section on degenerative disorders of the brain begins wtih details about the dopaminergic neurons in the substantia niger and their loss in Parkinson's disease. Two subsequent chapters describe changes in brain aging, including changes in the numbers of myelinated axons. Other chapters in this section describe important cellular and molecular changes found in Alzheimer's disease and human epilepsy. Together, these chapters summarize much of our current knowledge about the major molecular and cellular changes found in several degenerative diseases of the brain.

The last section addresses the issues of brain plasticity and regeneration in the adult brain and begins with a chapter on how the brain's own stem cells provide newly generated neurons to the hippocampal dentate gyrus and how these neurons become integrated into neural circuitry. The following two chapters examine some of the neuroplastic changes that take place in motor and sensory cortices of awake behaving primates. The concluding two chapters address the issue of regeneration in the injured spinal cord and the factors that may contribute to its success.

From Development to Degeneration and Regeneration of the Nervous System

Charles E. Ribak PhD, Carlos Aramburo de la Hoz Phd, Edward G. Jones, PhD, Jorge A. Larriva Sahd, PhD, and Larry W. Swanson PhD

Contents
1:The Legacy of Cajal in Mexico, Jose Luis Diaz
Part 1. Neuronal Migration and Development
2:Tangential Cell Movements During Early Telencephalic Development, Juan de Carlos and Fernando Garcia-Moreno
3:Gene Control of Cajal-Retzius Cell Development, Amaya Miguelajauregui and Alfredo Varela-Echavarria
4:Development of the Paraventricular Nucleus of the Hypothalamus, Larry Sawnson
5:Neural Tube Defects: New Insights on Risk Factors, Enrique Pedernera, V.R. Nunez, and C. Mendez
6:Quantitative Electroencephalography in the Normal and Abnormal Developing Human Brain, Thalia Harmony, Alfonso Alba, Jose Luis Marroquin, Antonio Fernandez-Bouzas, Gloria Avecilla, Josefina Ricardo-Garcell, Efrain Santiago-Rodriguez, Gloria Otero, Eneida Porras-Kattz, and Thalia Fernandez
Part II. Degenerative Brain Diseases
7:The Nigro-Striatal DA Neurons and Mechanisms of their Degeneration in Parkinson's Disease, Kjell Fuxe, Daniel Marcellino, Tiziana Antonelli, Giuseppa Mudo, Paul Manger, Susanna Genedani, Luca Ferraro, Natale Belluardo, Sergio Tanganelli, and Luigi F. Agnatti
8:Degeneration and Regeneratino of Myelin in the Central Nervous System of the Aging Monkey, Alan Peters
9:Degeneration in Canine Brain Again, Elizabeth Head
10:Alzheimer's Disease-Related Mechanisms of Neuronal Dysfunction and Degeneration: Studies in Human Cortical Neurons, Jorge Busciglio and Atul Deshpande
11:Aberrant Cells and Synaptic Circuits in Pediatric Epilepsy Surgery Patients, Carlos Cepeda, Veronique M. Andre, Irene Yamazaki, Max Kleiman-Weiner, Robin S. Fisher, Harry V. Winters, Michael S. Levine, and Gary W. Mathern
Part III. Neural Plasticity and Regeneration
12:Developmental Profile of Newly-Generated Granule Cells in the Adult Rodent Dentate Gyrus, Charles E. Ribak, Zachary D. Perez, and Lee A. Shapiro
13:Functional Architecture of Directional Tuning in the Primate Motor Cortext During 3D Reaching, Hugo Merchant, Thomas Naselaris, Wilbert Zarco, Ramon Bartolo, Luis Prado, Oswaldo Perez, Karina Yc, and Juan Carlos Mendez
14:Neural Codes for Perceptual Decisions, Ranulfo Romo, Adrian Hernandez, Luis Lemus, Rogelio Luna, Antonio Zainos, Veronica Nacher, Manuel Alvarez, Yuriria Vasquez, Silvia Cordero, and Liliana Camarillo
15:Human Neural Stem Cell Mediated Repair of the Contused Spinal Cord: Timing the Microenvironment, Aileen Anderson, Brian J. Cummings, Mitra J. Hooshmand, and Desiree L. Salazar
16:Spinal Cord Injury Pathology Differs wtih Injury Type, Age, and Exercise, Hans Keirstead and Monica M. Siegenthaler

From Development to Degeneration and Regeneration of the Nervous System

Charles E. Ribak PhD, Carlos Aramburo de la Hoz Phd, Edward G. Jones, PhD, Jorge A. Larriva Sahd, PhD, and Larry W. Swanson PhD

Reviews and Awards

"This is a complete account of the evolution of a field that in over 100 years of development transformed the way we envision neuroscience." - Celso Agner, MD, MSc (University of Illinois at Chicago College of Medicine)