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Evolution in Health and Disease

Second Edition

Stephen C. Stearns and Jacob C. Koella

Describes how evolutionary thinking gives insight into human health and disease
Explains why we grow old, and how to stay healthy as we age
Suggests exciting possibilities for future treatment and research
Includes contributions from the leading researchers in the field

$88.00

Paperback

Published: 10 January 2008

368 Pages | 57 b&w line, 1 halftone

7-1/5 x 9-3/4 inches

ISBN: 9780199207466

Also Available As:

Hardcover

Hardcover

$162.00

10 January 2008

Ebook

This title is available as an ebook. To purchase, visit your preferred ebook provider.

Also Available In:

Oxford Scholarship Online

This book is available as part of Oxford Scholarship Online - view abstracts and keywords at book and chapter level.

Bookseller Code (06)

Evolution in Health and Disease

Second Edition

Stephen C. Stearns and Jacob C. Koella

Description

In this fully revised and updated edition, the editors have integrated a completely new set of contributions from the leading researchers in the field to describe the latest research in evolutionary medicine, providing a fresh summary of this rapidly expanding field 10 years after its predecessor was first compiled. It continues to adopt a broad approach to the subject, drawing on medically relevant research from evolutionary genetics, human behavioral ecology, evolutionary microbiology (especially experimental evolution of virulence and resistance), the evolution of aging and degenerative disease, and other aspects of biology or medicine where evolutionary approaches make important contributions.

Evolution in Health and Disease describes how evolutionary thinking gives valuable insights and fresh perspectives into human health and disease, establishing evolutionary biology as an essential complementary science for medicine. Integrating evolutionary thought into medical research and practice helps to explain the origins of many medical conditions, including diabetes, obesity, cardiovascular disease, asthma, allergies, other autoimmune diseases, and aging. It also provides life-saving insights into the evolutionary responses of pathogens to antibiotics, vaccinations, and other human interventions. Why do we grow old? How can we stay healthy as we age? The book discusses these and many other fascinating questions, as well as suggesting exciting possibilities for future treatment and research.

This research level text is suitable for graduate level students and researchers in the fields of evolutionary (Darwinian) medicine, evolutionary biology, anthropology, developmental biology and genetics. It will also be of relevance and use to medical researchers and doctors.

Evolution in Health and Disease

Second Edition

Stephen C. Stearns and Jacob C. Koella

Preface
Part I. Introduction
Chapter 1. Introducing evolutionary thinking for medicine, by Stephen C. Stearns, Randolph M. Nesse, and David Haig
Part II. The history and variation of human genes
Chapter 2. Global spatial patterns of infectious diseases and human evolution, by Jean-François Guégan, Franck Prugnolle, and Frédéric Thomas
Chapter 3. Medically relevant variation in the human genome, by Diddahally R. Govindaraju and Lynn B. Jorde
Chapter 4. Health consequences of ecogenetic variation, by Michael Bamshad and Arno G. Motulsky
Chapter 5. Human genetic variation of medical significance by Kenneth K. Kidd and Judith R. Kidd
Part III. Natural selection and evolutionary conflicts
Chapter 6. Intimate relations: evolutionary conflicts of pregnancy and childhood, by David Haig
Chapter 7. How hormones mediate tradeoffs in human health and disease, by Richard G. Bribiescas and Peter T. Ellison
Chapter 8. Functional significance of MHC variation in mate choice, reproductive outcome, and disease risk, by Dagan A. Loisel, Susan C. Alberts, and Carole Ober
Chapter 9. Perspectives on human health and disease from evolutionary and behavioral ecology, by Beverly I. Strassmann and Ruth Mace
Part IV. Pathogens: resistance, virulence, variation, and emergence
Chapter 10. The ecology and evolution of antibiotic resistant bacteria, by Carl T. Bergstrom and Michael Feldgarden
Chapter 11. Pathogen evolution in a vaccinated world, by Andrew F. Read and Margaret J. Mackinnon
Chapter 12. The evolution and expression of virulence, by Dieter Ebert and James J. Bull
Chapter 13. Evolutionary origins of diversity in human viruses, by Paul M. Sharp, Elizabeth Bailes, and Louise V. Wain
Chapter 14. The population structure of pathogenic bacteria, by Daniel Dykhuizen and Awdhesh Kalia
Chapter 15. Whole-genome analysis of pathogen evolution, by Julian Parkhill
Chapter 16. Emergence of new infectious diseases, by Mark Woolhouse and Rustom Antia
Chapter 17. Evolution of parasites, by Jacob C. Koella and Paul Turner
Part V. Noninfectious and degenerative disease
Chapter 18. Evolutionary biology as a foundation for studying aging and aging-related disease, by Martin Ackermann and Scott D. Pletcher
Chapter 19. Evolution, developmental plasticity, and metabolic disease, by Christopher W. Kuzawa, Peter D. Gluckman, Mark A. Hanson, and Alan S. Beedle
Chapter 20. Lifestyle, diet, and disease: comparative perspectives on the determinants of chronic health risks, by William R. Leonard
Chapter 21. Cancer: evolutionary origins of vulnerability, by Mel Greaves
Chapter 22. Cancer as a microevolutionary process, by Natalia L. Komarova and Dominik Wodarz
Chapter 23. The evolutionary context of human aging and degenerative disease, by Steven N. Austad and Caleb E. Finch
References
Index

Evolution in Health and Disease

Second Edition

Stephen C. Stearns and Jacob C. Koella

Author Information

Professor Stearns specializes in life history evolution, which links the fields of ecology and evolutionary biology, in evolutionary medicine, and in evolutionary functional genomics. He came to Yale in 2000 from the University of Basel, Switzerland, where he had been professor of zoology since 1983 and held several administrative posts. Prior to moving to Basel he was an assistant professor in the Biology Department at Reed College in Oregon. Born in Hawaii and a 1967 graduate of Yale College, Stearns earned a M.S. from the University of Wisconsin and a Ph.D. from the University of British Columbia.

Professor Koella's interests lie in the coevolution of parasites and hosts. He specializes in the evolutionary epidemiology of malaria and in the application of evolutionary ideas to the control of malaria. After obtaining a Masters' in mechanical engineering at the ETH Zurich and a PhD in evolutionary biology at the University of Basel he worked for several years at the Swiss Tropical Institute Basel as a malaria epidemiologist before moving on to positions in Switzerland, Denmark and France. He arrived at Imperial College in 2005 as a Chair in Epidemiology.

Contributors:

Martin Ackermann
Susan C. Alberts
Rustom Antia
Steven N. Austad
Elizabeth Bailes
Michael Bamshad
Alan S. Beedle
Carl T. Bergstrom
Richard G. Bribiescas
James J. Bull
Daniel Dykhuizen
Dieter Ebert
Peter T. Ellison
Michael Feldgarden
Caleb E. Finch
Peter D. Gluckman
Diddahally R. Govindaraju
Mel Greaves
Jean-François Guégan
David Haig
Mark A. Hanson
Lynn B. Jorde
Awdhesh Kalia
Kenneth K. Kidd
Judith R. Kidd
Jacob C. Koella
Natalia L. Komarova
Christopher W. Kuzawa
William R. Leonard
Dagan A. Loisel
Ruth Mace
Margaret J. Mackinnon
Arno G. Motulsky
Randolph M. Nesse
Carole Ober
Julian Parkhill
Scott D. Pletcher
Franck Prugnolle
Andrew F. Read
Paul M. Sharp
Stephen C. Stearns
Beverly I. Strassmann
Frédéric Thomas
Paul Turner
Louise V. Wain
Dominik Wodarz
Mark Woolhouse