Emerging Trends in Dietary Components for Preventing and Combating Disease

Edited by Bhimanagouda S.; Patil, Guddadarangavvanahally K. Jayaprakasha, Kotamballi N. Chidambara Murthy, and Navindra P. Seeram

American Chemical Society

ACS Symposium Series

Provides an integrated approach to address the chemistry of natural products for their application in disease prevention through in vitro, animal and human intervention studies
Presents studies by interdisciplinary scientists including horticulturists, natural products chemists, and pharmacologists
Presents in vitro models for preventing and combating disease, including products derived from olives, hawthorn, goji, carrot, citrus, berry, and sugar maple

Emerging Trends in Dietary Components for Preventing and Combating Disease

Edited by Bhimanagouda S.; Patil, Guddadarangavvanahally K. Jayaprakasha, Kotamballi N. Chidambara Murthy, and Navindra P. Seeram

American Chemical Society

Description

The World Health Organization (WHO) estimates that nearly 80% of the consumers in the world utilize plant products as their first line of defense against diseases and as their primary sources of medicines; meanwhile, approximately 47% of the drugs approved by FDA during 1981-2006 were originally derived from natural products. Recent research from several laboratories around the world has confirmed the long-held belief that several agricultural and food derived products have a profound impact on human health. Here, interdisciplinary scientists including horticulturists, natural products chemists, and pharmacologists address this issue. The chapters presented here are selected from a special symposium entitled Agricultural and Food Derived Natural Products for Preventing and Combating Disease organized by the co-editors at the recent 240th American Chemical Society National Meeting, August 22-26, 2010, in Boston, MA.

This book provides an integrated approach to address the chemistry of natural products for their application in disease prevention through in vitro, animal and human intervention studies. The book covers three main areas: 1) Purification and characterization of certain natural compounds, 2) In vitro models for prevention and combating disease, 3) In vivo and human intervention models for prevention and combating diseases.
The first area focuses on chemistry of natural products with studies involving isolation methods and elucidation of structural properties of natural compounds from various fruits, vegetables and medicinal plants. Following up on the chemistry, in vitro models for preventing and combating disease are presented, notably models involving products derived from olives, hawthorn, goji, carrot, citrus, berry, and sugar maple. Several other indigenous plants from different regions of the world such as Chilean and Mediterranean wild plants Azadiracta indica and Echinacea pallida provide further understanding of the development of both traditional and innovative plant-based healing medicines.
The third and fourth areas covered in the book impart an overview on the future applicability of the natural products. Results from studies on anthocyanin based fruits and vegetables including berries, natural pigments, sesamol, Okra seeds, Grape seed extract, and Methyl jasmonate demonstrate their health benefits through modulation of different metabolic pathways.
Given that the worldwide incidence of heart disease, cancer and other chronic human illnesses is rapidly increasing, intervention with agricultural and food derived natural products provides an attractive strategy for disease prevention. Therefore, the focused and timely discussions in this book will be of great interest to both basic and clinical researchers as well as other health care professionals. The book will facilitate further research in this area.

Emerging Trends in Dietary Components for Preventing and Combating Disease

Edited by Bhimanagouda S.; Patil, Guddadarangavvanahally K. Jayaprakasha, Kotamballi N. Chidambara Murthy, and Navindra P. Seeram

American Chemical Society

ACS Symposium Series

Contents
Preface

I. Characterization of Disease Preventing Components

1. Chromatographic Techniques for the Separation of Polymethoxyflavones from Citrus
Ram M. Uckoo, G. K. Jayaprakasha, and Bhimanagouda S. Patil
2. Flavonoids and Furocoumarins in Bergamot, Myrtle-Leaved Orange, and Sour Orange Juices: Distribution and Properties
Davide Barreca, Ersilia Bellocco, Corrado Caristi, Ugo Leuzzi, and Giuseppe Gattuso
3. Cancer Chemopreventive Properties of Citrus Limonoids
Jinhee Kim, G. K. Jayaprakasha, Amit Vikram, and Bhimanagouda S. Patil
4. Isolation and Chemical Characterization of Components with Biological Activity Extracted from Azadirachta indica and Melia azedarach
P. Caboni, N. G. Ntalli, C. E. Bueno, and L. E. Alchè
5. Phytochemicals from the Fruit and Foliage of Cranberry (Vaccinium macrocarpon) - Potential Benefits for Human Health
Christine A. Dao, Kunal D. Patel, and Catherine C. Neto
6. Maqui Berry (Aristotelia chilensis) Juices Fermented with Yeasts: Effects on Phenolic Composition, Antioxidant Capacity, and iNOS and COX-2
Protein Expression
Jin Zhi Wang, Gad G. Yousef, Randy B. Rogers, Elvira Gonzalez de Mejia,
Ilya Raskin, and Mary Ann Lila
7. Potential Therapeutic Applications of Common Agro-Food Byproducts and Chilean Wild Plants
J. Sineiro, M. Rubilar, M. Cascante, E. Álvarez, M. Sánchez, and M. J. Núñez
8. Isolation, Structure Elucidation, Synthesis, and Cytotoxic Activity of Polyacetylenes and Polyenes from Echinacea pallida
Federica Pellati, Stefania Benvenuti, Fabio Prati, and Paola Nieri
9. Wild Blueberries (Vaccinium angustifolium): Modulators of Vascular Function, Structure, and Metabolism
Dorothy Klimis-Zacas and Aleksandra S. Kristo
10. Carrot Bisacetylenic Oxylipins - Phytochemicals Behind the Mask of the Superfood
Brandon T. Metzger, Ph.D.
11. Nontargeted Profiling of Specialized Metabolites of Digitalis purpurea with a Focus on Cardiac Glycosides
Farzad Shadkami and A. Daniel Jones

II. Components from Exotic Species for Combating Diseases

12. Mediterranean Wild Plants As Useful Sources of Potential Natural Food Additives
Monica Scognamiglio, Brigida D'Abrosca, Severina Pacifico, Marina Isidori, Assunta Esposito, and Antonio Fiorentino
13. Beyond Olive Oil: Active Components and Health Aspects of Some Less Studied Mediterranean Plant Products
Nick Kalogeropoulos, Antonia Chiou, Andriana C. Kaliora, Vaios T. Karathanos, and Nikolaos K. Andrikopoulos
14. Hypoglycemic Bioactives from a Traditional Herb
C. Y. Choo, A. NoorShahida, and T. W. Wong
15. Sugars, Acids, and Phenolic Compounds in Chinese Hawthorn (Crataegus spp.) Fruits of Different Origins
Baoru Yang, Pengzhan Liu, and Heikki Kallio
16. Bioactive Compounds from Okra Seeds: Potential Inhibitors of Advanced Glycation End Products
Bishambar Dayal, Vineela Reddy Yannamreddy, Ajay P. Singh, Michael Lea, and Norman H. Ertel
17. Jasmonates: Plant Stress Hormones as Anticancer Agents
Dorit Reischer-Pelech and Eliezer Flescher
18. Chemical Composition and Biological Effects of Maple Syrup
Liya Li and Navindra P. Seeram
19. Sesame Seed (Sesamum indicum L.) Extracts and Their Anti-Inflammatory Effect
Dur-Zong Hsu, Pei-Yi Chu, and Ming-Yie Liu

III. In Vitro and in Vivo Evidences of Dietary Components for Health Benefits

20. Functional Food Components for Preventing and Combating Type 2 Diabetes
Dipayan Sarkar, Chandrakant Ankolekar, and Kalidas Shetty
21. Urinary Pharmacokinetics of Queen Garnet Plum Anthocyanins in Healthy Human Subjects
M. Netzel, K. Fanning, G. Netzel, T. Frank, D. Zabaras, D. Russell, and R. Stanley
22. Conjugated Fatty Acids as a Prevention Tool for Obesity and Osteoporosis
Yeonhwa Park and Yooheon Park
23. NMR Spectroscopy-Based Metabolic Profiling for Detecting Hepatobiliary Diseases
G. A. Nagana Gowda and Daniel Raftery
24. Influence of the Target Molecule on the ORAC Index
Camilo López-Alarcón, Alexis Aspée, and Eduardo Lissi
25. Inhibition of Intestinal ?-Glucosidases and Anti-Postprandial Hyperglycemic Effect of Grape Seed Extract
Kequan Zhou, Shelly Hogan, Corene Canning, and Shi Sun
26. Fruit and Vegetable Polyphenol Consumption Decreases Blood Pressure
Rosa-Maria Lamuela-Raventos, Alexander Medina-Remón, Anna Tresserra-Rimbau, and Ramón Estruch
27. The Pig Cecum Model - A Powerful Tool for Studying the Intestinal Metabolism of Flavonoids
Gordon van't Slot, Katrin Rose, Anna Engemann, and Hans Ulrich Humpf
28. Cellular Antioxidant Defenses and Amelioration by Biopigments with Particular Focus on mRNA Oxidations
Bhagyalakshmi Neelwarne and Jyothi Maria Veigas
29. Thylakoids Promote Satiety in Healthy Humans. Metabolic Effects and Mechanisms
Charlotte Erlanson-Albertsson, Per-Åke Albertsson, Karolina Gustafsson, Caroline Montelius, Sinan C. Emek, Rickard Köhnke, and Mona Landin-Olsson
30. Nutrition in the Treatment of Dry Eye with Special Attention to Sea Buckthorn Oil
Petra S. Larmo, Baoru Yang, Riikka L. Järvinen, Niko L. Setälä, Matti H. Viitanen, and Heikki P. Kallio
31. Citrus Monoterpenes: Potential Source of Phytochemicals for Cancer Prevention
Kotamballi N. Chidambara Murthy, G. K. Jayaprakasha, Shivappa M. Mantur, and Bhimanagouda S. Patil
32. Anthocyanin Bioavailability: Past Progress and Current Challenges
Janet A. Novotny

Editors' Biographies

APPENDIX A
Ram M. Uckoo, G. K. Jayaprakasha, and Bhimanagouda S. Patil
APPENDIX B
P. Caboni, N. G. Ntalli, C. E. Bueno, and L. E. Alchè
APPENDIX C
Liya Li and Navindra P. Seeram
APPENDIX D
M. Netzel, K. Fanning, G. Netzel, T. Frank, D. Zabaras, D. Russell, and R. Stanley

Indexes
Author Index
Subject Index

Emerging Trends in Dietary Components for Preventing and Combating Disease

Edited by Bhimanagouda S.; Patil, Guddadarangavvanahally K. Jayaprakasha, Kotamballi N. Chidambara Murthy, and Navindra P. Seeram

American Chemical Society

ACS Symposium Series

Author Information

Bhimanagouda S. Patil is Associate Professor in the Department of Horticultural Sciences in Texas A&M University in College Station.

Guddadarangavvanahally K. Jayaprakasha is Research Assistant Professor in the Department of Horticultural Sciences in Texas A&M University in College Station.

Kotamballi N. Chidambara Murthy is Research Associate at Texas A&M University in College Station.

Navindra P. Seeram is Assistant Professor of Pharmacognosy at the University of Rhode Island.