Depression

Edited by Madhukar H. Trivedi and Series edited by Steven M. Strakowski

Primer On

Provides a comprehensive review of depression from diagnosis to treatment
Includes sections on diagnosis and treatment considerations for special populations, such as youth, the elderly, and those with chronic or acute medical conditions
Examines how research on biological markers may lead to precision medicine
Includes both pharmacologic and non-pharmacologic treatment of depression

Depression

Edited by Madhukar H. Trivedi and Series edited by Steven M. Strakowski

Description

Major depressive disorder (MDD) is a serious, debilitating, life-shortening illness that affects many persons of all ages and backgrounds. The lifetime risk for MDD is 7-12% for men and 20-25% for women (Kessler et al., 2003). MDD is a disabling disorder that costs the U.S. over $200 billion per year in direct and indirect costs (Greenberg et al., 2015), and is the leading cause of disability worldwide (WHO, 2018). Depression also has detrimental effects on all aspects of social functioning (e.g., self-care, social role, and family life, including household, marital, kinship, and parental roles). While there have been several treatments that are efficacious, many individuals suffering from depression experience life-long challenges due to the chronic and episodic nature of the disease. Identifying strategies to find the right treatments for the right patients is critical. Ongoing research has explored the importance of examining physiologic biomarkers, as well as clinical characteristics to gain a better understanding of subtypes of depression, which will lead to improved treatments and better outcomes.

This book provides an introduction to the etiology and pathophysiology of depression, common comorbidities and differential diagnoses, pharmacotherapy strategies, psychotherapeutic and neuromodulation interventions, novel and non-traditional treatment strategies, and considerations in special populations.

Depression

Edited by Madhukar H. Trivedi and Series edited by Steven M. Strakowski

Primer On

1.Introduction and Overview
I. Etiology/Pathophysiology
2. Neurobiology
3. Genetic Risk Factors
4. Environmental and Social Risk Factors
5. Blood-based Biomarkers
II. Comorbidities and Differential Diagnoses
6. Anxiety Disorders
7. Bipolar Disorder
8. Suicidality
9. General Medical Conditions
10. General Medical Conditions, Metabolic Disorders
III. Pharmacotherapy for Depression
11. First line and combination therapeutics
12. Augmentation strategies
13. Rapid-acting antidepressants
14. Side Effects of Antidepressant
15. Strategies for targeting residual symptoms
IV. Psychotherapy and modalities of delivery for Depression
16. Cognitive Behavioral Therapy/Behavioral Activation
17. Behavioral Activation for Depression
18. Psychodynamic and Supportive Psychotherapy
19. ECT/TMS
V. Novel, Non-Traditional Treatment Strategies for Depression
20. Exercise as a treatment for depression
21. Therapeutic Mindfulness For Relapse Prophylaxis in Unipolar Depression
22. Probiotics and Neutraceuticals
23. Chronobiological Treatments: Sleep and Light Therapies
VI. Special Populations in Depression
24. Children and Adolescents
25. Elderly Patients
26. Pregnant and Postpartum
27. Depression Following Mild Traumatic Brain Injury
28. Treatment in Primary Care
VII. MISCELLANEOUS
29. Future Directions: Precision Medicine and Biosignatures

Depression

Edited by Madhukar H. Trivedi and Series edited by Steven M. Strakowski

Primer On

Author Information

Madhukar Trivedi is Professor of Psychiatry, Chief of the Division of Mood Disorders, and Founding Director of the Center for Depression Research and Clinical Care at UT Southwestern Medical Center. He is an internationally recognized translational researcher focusing on developing and validating biosignatures of depression. He specializes in treating depression and conducts research on pharmacological, psychosocial, and nonpharmacological treatments for depression, including ketamine, magnetic stimulation, and exercise.

Holding the Betty Ho Hay Distinguished Chair in Mental Health and the Julie K. Hersh Chair for Depression Research and Clinical Care at UTSW, Dr. Trivedi has received numerous accolades, including the Psychiatric Excellence Award from the Texas Society of Psychiatric Physicians and the Gerald Klerman Senior Investigator Award from the Depression and Bipolar Support Alliance. With over 500 articles and chapters related to the diagnosis and treatment of mood disorders, Dr. Trivedi was listed on Thomas Reuters' World's Most Influential Scientific Minds in each year since 2014 as one of the most highly cited researchers in the U.S. field of Psychiatry.

Series editor: Steven M. Strakowski, MD, Founding Chair, Department of Psychiatry, Dell Medical School, University of Texas, Austin

Contributors:

David Benrimoh, MD
McGill Group for Suicide Studies
Department of Psychiatry
McGill University
Montreal, Quebec, Canada

John P. Coetzee, PhD
Postdoctoral Scholar
Department of Psychiatry and Behavioral Sciences
Stanford University School of Medicine
Health Fellow
Division of Polytrauma
Veteran's Health Administration
Palo Alto, CA, USA

Callan M. Coghlan, BA
Research Specialist
Department of Psychiatry and Behavioral Sciences
Emory University School of Medicine
Atlanta, GA, USA

Evan Collins, MD, FRCPC
Assistant Professor Department of Psychiatry
University of Toronto
Toronto, Canada

C. Munro Cullum, PhD, ABPP
Professor of Psychiatry, Neurology, and Neurosurgery
Department of Psychiatry
University of Texas Southwestern Medical Center
Dallas, TX, USA

Andrew H. Czysz, MD, PhD
Center for Depression Research and Clinical Care
Department of Psychiatry
University of Texas Southwestern Medical Center
Dallas, TX, USA

Sabrina C. da Costa, MD
Department of Psychiatry
Yale University School of Medicine
Addiction Psychiatry Program
New Haven, CT, USA
Department of Psychiatry and Behavioral Sciences
McGovern Medical School
University of Texas Health Science Center at Houston
Houston, TX, USA

Sylvanne Daniels, PhD
McGill Group for Suicide Studies
Department of Psychiatry
McGill University
Montreal, Quebec, Canada

Brett Davis, BA
Semel Institute for Neuroscience and Behavior
David Geffen School of Medicine
University of California, Los Angeles
Los Angeles, California

Lori L. Davis, MD
Department of Psychiatry and Behavioral Neurobiology
University of Alabama at Birmingham
Birmingham, AL
Research and Development Service
Tuscaloosa VA Medical Center
Tuscaloosa, AL

Zhi- De Deng, PhD
Director, Computational Neurostimulation Research Program
Noninvasive Neuromodulation Unit
Experimental Therapeutics and Pathophysiology Branch
National Institute of Mental Health
Bethesda, MD, USA

Andrew Diederich, MD
Assistant Professor
Child and Adolescent Division
University of Texas Southwestern
Department of Psychiatry
University of Texas Southwestern Medical Center
Dallas, TX, USA

Steven C. Dufour, BA
Department of Psychiatry
Massachusetts General Hospital
Boston, MA, USA

Graham J. Emslie, MD
Professor
Department of Psychiatry
University of Texas Southwestern Medical Center
Dallas, TX, USA

Maurizio Fava, MD
Director
Division of Clinical Research/ MGH Research Institute
Massachusetts General Hospital
Boston, MA, USA

Bharathi S. Gadad, PhD
Assistant Professor
Department of Psychiatry
Texas Tech University Health Science Center
El Paso, TX, USA
Center for Depression Research and Clinical Care
Department of Psychiatry
University of Texas Southwestern Medical Center
Dallas, TX, USA

Tracy L. Greer, PhD, MSCS
Center for Depression Research and Clinical Care
Department of Psychiatry
University of Texas Southwestern Medical Center
Dallas, TX, USA

Thorhildur Halldorsdottir, PhD
Centre of Public Health Sciences
Faculty of Medicine
University of Iceland
Reykjavik, Iceland
Department of Translational Research in Psychiatry
Max Planck Institute of Psychiatry
Munich, Germany

David J. Hellerstein, MD
Professor of Clinical Psychiatry
Department of Psychiatry
Columbia University Irving Medical Center
New York, NY, USA

Ioline D. Henter, MA
Technical Publications Writer
Section on the Neurobiology and Treatment of Mood Disorders
Intramural Research Program
National Institute of Mental Health
Bethesda, MD, USA

Steven D. Hollon, PhD
Gertrude Conway Vanderbilt Professor
Department of Psychology
Vanderbilt University
Nashville, TN, USA

Jennifer L. Hughes, PhD, MPH
Center for Depression Research and Clinical Care
Department of Psychiatry
University of Texas Southwestern
Medical Center
Dallas, TX, USA

Sonia Israel
McGill Group for Suicide Studies
Department of Psychiatry
McGill University Douglas Mental
Health University Institute
Montreal, Quebec, Canada

Jessica A. Janos, BA
Department of Psychology and Neuroscience
University of North Carolina
Chapel Hill, NC

Manish K. Jha, MBBS
Department of Psychiatry
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Jessica M. Jones, MA
Research Scientist
Department of Psychiatry
University of Texas Southwestern Medical Center
Dallas, TX, USA

Bashkim Kadriu, MD
Clinical Fellow
National Institute of Mental Health
National Institutes of Health
Bethesda, MD, USA

Farra Kahalnik, MSSW, MPH
Department of Psychiatry
Center for Depression Research and Clinical Care
University of Texas Southwestern
Medical Center
Dallas, TX, USA

Alexander Kane, MD
Assistant Professor of Clinical Psychiatry
Weill Cornell Medical College
Assistant Inpatient Attending
NewYork-Presbyterian Hospital
New York, NY, USA

Jordan F. Karp, MD
Department of Psychiatry
University of Pittsburgh School of Medicine
Pittsburgh, PA, USA

Robert S. Kinney, BSc
McGill Group for Suicide Studies
Department of Psychiatry
McGill University
Montreal, Quebec, Canada

Emily B. Kroska
Department of Psychiatry
University of Wisconsin Madison
Madison, WI

Raymond W. Lam, MD, FRCPC
Professor and BC Leadership Chair in Depression Research
Department of Psychiatry
University of British Columbia
Vancouver, BC, Canada

Eric J. Lenze, MD
Wallace and Lucille K. Renard
Professor of Psychiatry
Department of Psychiatry
Washington University School of Medicine
St. Louis, MO, USA

Julio Licinio, MD, PhD, MBA
Professor of Psychiatry, Pharmacology, Medicine, and Neuroscience & Physiology
College of Medicine
SUNY Upstate Medical University
Syracuse, NY, USA

Rajnish Mago, MD
Editor- in- Chief
Simple and Practical Mental Health
Clinical Assistant Professor of Psychiatry
Perelman School of Medicine, University of Pennsylvania
Philadelphia, PA, USA

Brittany L. Mason, PhD
Assistant Professor
Department of Psychiatry
University of Texas Southwestern Medical Center
Dallas, TX, USA

Taryn L. Mayes, MS
University of Texas Southwestern Medical Center
Dallas, TX, USA

Catherine Munro, PhD
Doctoral Candidate, Clinical Psychology
Department of Psychiatry
University of Texas Southwestern Medical Center
Dallas, TX, USA

Hanadi Ajam Oughli, MD
Healthy Mind Lab
Department of Psychiatry
Washington University in Saint Louis School of Medicine
St. Louis, MO, USA

George I. Papakostas, MD
Clinical Trials Network and Institute
Massachusetts General Hospital
Harvard Medical School
Boston, MA, USA

Lawrence T. Park, MD
Director
Experimental Therapeutics and Pathophysiology Branch
National Institute of Mental Health
Bethesda, MD, USA

Nikita Patel, BS, Psych
Department of Psychiatry
University of Wisconsin Madison
Madison, WI

Seth W. Perry, PhD
Associate Professor of Psychiatry and Neuroscience & Physiology
Department of Psychiatry
SUNY Upstate Medical University
Syracuse, NY, USA

Patricia Pilkinton, MD
Department of Psychiatry and Behavioral Medicine
University Medical Center, University of Alabama
Tuscaloosa, AL
Research and Development Service
Tuscaloosa VA Medical Center
Tuscaloosa, AL

Radu Pop, PhD
Department of Psychiatry
Center for Depression Research and Clinical Care
University of Texas Southwestern Medical Center
Dallas, TX, USA

Chad D. Rethorst, PhD
Center for Depression Research and Clinical Care
Department of Psychiatry
University of Texas Southwestern Medical Center
Dallas, TX, USA

Barbara O. Rothbaum, PhD, ABPP
Professor in Psychiatry
Department of Psychiatry and Behavioral Sciences
Emory University School of Medicine
Atlanta, GA, USA

Naji C. Salloum, MD
Clinical Trials Network and Institute
Massachusetts General Hospital,
Harvard Medical School
Boston, MA, USA

Marsal Sanches, MD, PhD
Associate Professor
Department of Psychiatry and Behavioral Sciences
McGovern Medical School
Houston, TX, USA

Eduardo J. Sanchez, MD, MPH
Chief Medical Officer for Prevention
Chief, Center for Health Metrics and Evaluation
American Heart Association
Dallas, TX, USA

Katherine Sanchez, PhD, LCSW
Associate Professor
School of Social Work
The University of Texas at Arlington
Arlington, TX, USA

Zindel Segal, PhD, CPsych
Departments of Psychological Clinical Science and Psychiatry
University of Toronto
Toronto, Ontario, Canada

Bonnie Seifert, BS
Project Coordinator and Data Information Specialist
Department of Psychiatry and Behavioral Sciences
Emory University School of Medicine
Atlanta, GA, USA

Jair C. Soares, MD, PhD
Professor and Chairman Pat R. Rutherford Chair in Psychiatry
Department of Psychiatry and Behavioral Sciences
Executive Director, UT Harris County
Psychiatric Center Director, UT
Center of Excellence on Mood Disorders
UTHealth School of Medicine
Houston, TX, USA

Zachary N. Stowe
Department of Psychiatry
University of Wisconsin Madison
Madison, WI

Subha Subramanian, MD
Section on the Neurobiology and Treatment of Mood Disorders
Intramural Research Program, National Institute of Mental Health
Bethesda, MD, USA

Louisa G. Sylvia, PhD
Department of Psychiatry
Massachusetts General Hospital
Department of Psychiatry
Harvard Medical School
Boston, MA, USA

Madhukar H. Trivedi, MD
Professor of Psychiatry; Director,
Center for Depression Research and Clinical Care
Betty Jo Hay Distinguished Chair in Mental Health
Julie K. Hersh Chair for Depression Research and Clinical Care
Department of Psychiatry
University of Texas Southwestern Medical Center
Dallas, TX, USA

Gustavo Turecki, MD, PhD
Professor
Department of Psychiatry
McGill University
Montreal, Quebec, Canada

Nolan Williams, MD
Assistant Professor
Director, Interventional Psychiatry
Clinical Research Director, Brain Stimulation Laboratory
Department of Psychiatry and Behavioral Sciences
Stanford University Medical Center
Palo Alto, CA, USA

Ma- Li Wong, MD, PhD
Professor of Psychiatry and Neuroscience & Physiology
College of Medicine
SUNY Upstate Medical University
Syracuse, NY, USA

Carly Yasinski, PhD
Assistant Professor
Department of Psychiatry and Behavioral Sciences
Emory University School of Medicine
Atlanta, GA, USA

Hildur Ýr Hilmarsdottir, BS
Centre of Public Health Sciences
Faculty of Medicine
University of Iceland
Reykjavik, Iceland

Carlos A. Zarate Jr., MD
Chief, Experimental Therapeutics & Pathophysiology Branch
Section on the Neurobiology and Treatment of Mood Disorders
Division of Intramural Research Program
National Institute of Mental Health
Bethesda, MD, USA