Complete Accounts of Integrated Drug Discovery and Development
Recent Examples from the Pharmaceutical Industry, Volume 2
Edited by Jaan. A Pesti, Ahmed F. Abdel-Magid, and Rajappa Vaidyanathan
Table of Contents
Preface
Chapter 1. Synthetic Routes for Venetoclax at Different Stages of Development Yi-Yin Ku and Michael D. Wendt
Chapter 2. Discovery and Development of Lorlatinib: A Macrocyclic Inhibitor of EML4-ALK for the Treatment of NSCLC Robert Dugger, Bryan Li, and Paul Richardson
Chapter 3. From Discovery to Market Readiness: The Research and Development of the B-Sparing Phosphatidylinositol 3-Kinase Inhibitor Taselisib Remy Angelaud, Steve Staben, Timothy Heffron, Andreas Schuster, and Frederic St-Jean
Chapter 4. Discovery and Development of the First Antibody-Antibiotic Conjugate Linker-Drug Stefan G. Koenig and Thomas H. Pillow
Chapter 5. The Discovery of the Nav1.7 Inhibitor GDC-0276 and Development of an Efficient Large-Scale Synthesis Andreas Stumpf, Daniel Sutherlin, Christoph M. Dehnhardt, and Remy Angelaud
Chapter 6. Discovery and Development of AMG 333: A TRPM8 Antagonist for Migraine Neil F. Langille and Daniel B. Horne
Chapter 7. The Discovery and Chemical Development of PF-06273340: A Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor for Pain David C. Blakemore, Thomas Brandt, Craig Knight, and Sarah E. Skerratt
Chapter 8. Optimization of an Azaindazole Series of CCR1 Antagonists and Development of a Semicontinuous-Flow Synthesis Christian Harcken, Joshuaine Grant, Hossein Razavi, Maurice A. Marsini, Frederic G. Buono, Jon C. Lorenz, and Jonathan T. Reeves
Chapter 9. Discovery and Development of Non-Covalent, Reversible Bruton's Tyrosine Kinase Inhibitor Fenebrutinib (GDC-0853) James J. Crawford and Haiming Zhang
Chapter 10. Discovery and Early Development of Small Molecule Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors David W. Piotrowski and Emma L. McInturff
Chapter 11. Rational Design to Large-Scale Synthesis: Development of GSK8175 for the Treatment of Hepatitis C Virus Infection Andrew J. Peat and Shiping Xie
Editors' Biographies
Author Index
Subject Index
