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Charney & Nestler's Neurobiology of Mental Illness

Fifth edition

Edited by Dennis S. Charney,MD , Eric J. Nestler,MD, PhD , Pamela Sklar,MD, PhD , and Joseph D. Buxbaum,PhD

New edition of this classic text, updated to cover advances in psychiatry following publication of the DSM-5
Comprehensively covers basic science to clinical disorders to treatments
Provides in-depth descriptions of molecular, cellular, systems, and behavioral research
Includes detailed information on clinical research, spanning studies of epidemiology, nosology, disease etiology and pathophysiology, and treatment efficacy
Discusses state-of-the-art methodologies in the field, both basic and clinical

Charney & Nestler's Neurobiology of Mental Illness

Fifth edition

Edited by Dennis S. Charney,MD , Eric J. Nestler,MD, PhD , Pamela Sklar,MD, PhD , and Joseph D. Buxbaum,PhD

Description

In the years following publication of the DSM-5®, the field of psychiatry has seen vigorous debate between the DSM's more traditional, diagnosis-oriented approach and the NIMH's more biological, dimension-based RDoC (research domain criteria) approach. Charney & Nestler's Neurobiology of Mental Illness is an authoritative foundation for translating information from the laboratory to clinical treatment, and its fifth edition extends beyond this reference function to acknowledge and examine the controversies, different camps, and thoughts on the future of psychiatric diagnosis.

In this wider context, this book provides information from numerous levels of analysis, including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. Sections and chapters are edited and authored by experts at the top of their fields. No other book distills the basic science and underpinnings of mental disorders-and highlights practical clinical significance-to the scope and breadth of this classic text.

In this edition, Section 1, which reviews the methods used to examine the biological basis of mental illness in animal and cell models and in humans, has been expanded to reflect critically important technical advances in complex genetics (including powerful sequencing technologies and related bioinformatics), epigenetics, stem cell biology, optogenetics, neural circuit functioning, cognitive neuroscience, and brain imaging. This range of established and emerging methodologies offer groundbreaking advances in our ability to study the brain as well as unique opportunities for the translation of preclinical and clinical research into badly needed breakthroughs in our therapeutic toolkit.

Sections 2 through 7 cover the neurobiology and genetics of major psychiatric disorders: psychoses (including bipolar disorder), mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood onset. Also covered within these sections is a summary of current therapeutic approaches for these illnesses as well as the ways in which research advances are now guiding the search for new treatments. Each of these parts has been augmented in several different areas as a reflection of research progress.

The last section, Section 8, reconfigured in this new edition, now focuses on diagnostic schemes for mental illness. This includes an overview of the unique challenges that remain in diagnosing these disorders given our still limited knowledge of disease etiology and pathophysiology. The section then provides reviews of DSM-5®, which forms the basis of psychiatric diagnosis in the United States for all clinical work, and of RDoC, which provides an alternative perspective on diagnosis in heavy use in the research community. Also included are chapters on future efforts toward precision and computational psychiatry, which promise to someday align diagnosis with underlying biological abnormalities.

Charney & Nestler's Neurobiology of Mental Illness

Fifth edition

Edited by Dennis S. Charney,MD , Eric J. Nestler,MD, PhD , Pamela Sklar,MD, PhD , and Joseph D. Buxbaum,PhD

Section 1: Emerging and Established Technologies
1. Genetic Methodologies and Applications
Shaun M. Purcell
2. Network Methods for Elucidating the Complexity of Common Human Diseases
Eric E. Schadt
3. The Human Brain and its Epigenome
Andrew Chess and Schahram Akbarian
4. Methods for In Vivo Gene Manipulation
Lisa M. Monteggia and Wei Xu
5. Application of Stem Cells to Understanding Psychiatric Disorders
Zijia Zhang and Kristen Brennand
6. Optogenetics and Related Technologies for Psychiatric Disease Research: Current Status and Challenges
Lief E. Fenno and Karl Deisseroth
7. In Vivo Circuit Analysis
Ryan Bowman, Hannah Schwennsen, Kafui Dzirasa, and Rainbo Hultman
8. Magnetic Resonance Methodologies
Peter A. Bandettini and Hanzhang Lu
9. PET Brain Imaging Methodologies
Ansel T. Hillmer, Kelly P. Cosgrove, and Richard E. Carson
10. Neuromodulation and Psychiatric Disorders
Wayne K. Goodman and Mark S. George
11. The Neurobiology of Sleep
Giulio Tononi and Chiara Cirelli
Section 2: Psychotic Disorders
12. Diagnosis and Epidemiology of Psychotic Disorders
Emma Meyer, Julie Walsh-Messinger, and Dolores Malaspina
13. Genetics of Schizophrenia and Bipolar Disorder
Pamela Sklar
14. Neuroimaging of Psychotic Disorders
Stephan Heckers, Neil Woodward, and Dost Öngür
15. Animal and Cellular Models of Psychotic Disorders
Mikhail V. Pletnikov, Guo-Li Ming, and Christopher A. Ross
16. Cognitive and Motivational Neuroscience of Psychotic Disorders: Animal and Human Studies
Jared Young, Alan Anticevic, and Deanna M. Barch
17. Synaptic Mechanisms of Psychotic Disorders: Animal and Human Studies
Seth G. N. Grant
18. Cellular Mechanisms of Psychotic Disorders: Human Studies
Samuel J. Dienel and David A. Lewis
19. Neurodevelopmental Mechanisms for Psychotic Disorders: Animal and Human Studies
Nao J. Gamo, Takeshi Sakurai, Hanna Jaaro-Peled, and Akira Sawa
20. The Neurobiology and Treatment of Bipolar Disorder
Katherine E. Burdick, Luz H. Ospina, Stephen J. Haggarty, and Roy H. Perlis
21. Novel Approaches for Treating Psychotic Disorders
Tiago Reis Marques and Shitij Kapur
22. Current Treatments for Psychotic Disorders
Deepak K. Sarpal and Anil K. Malhotra
Section 3: Depression
23. Diagnosis and Epidemiology of Depression
Nicholas T. Van Dam, Brian M. Iacoviello, and James W. Murrough
24. Genetics of Depression
Douglas F. Levinson and Walter E. Nichols
25. Neuroimaging of Depression
Michele A. Bertocci and Mary L. Phillips
26. Animal Models of Mood Disorders
Lyonna F. Alcantara, Eric M. Parise, and Carlos A. Bolaños-Guzmán
27. Neurotrophic Mechanisms of Depression: Animal and Human Studies
Ronald S. Duman
28. Immune Mechanisms of Depression
Caroline Ménard, Madeline L. Pfau, Georgia E. Hodes, and Scott J. Russo
29. Neuroendocrine Mechanisms of Depression: Clinical and Preclinical Evidence
Jill M. Goldstein, L Holsen, S Cherkerzian, M Misra, and RJ Handra
30. New Approaches for Treating Depression
Eric J. Nestler
31. Current Treatments for Depression
John H. Krystal and Dennis S. Charney
Section 4: Anxiety Disorders
32. Diagnosis and Epidemiology of Anxiety, Obsessive-Compulsive and Trauma- and Stressor-Related Disorders
Murray B. Stein, Meghan E. Keough, and Peter P. Roy-Byrne
33. Genetics of Anxiety Disorders
Takeshi Otowa, Roxann Roberson-Nay, Mandy Bekhbat, Gretchen N. Neigh, and John M. Hettema
34. Functional Neurocircuitry and Neuroimaging Studies of Anxiety Disorders
Madeleine S. Goodkind and Amit Etkin
35. Animal Models and Assays Probing anxiety Related Behaviors and Neural Circuits
Ramon Tasan and Nicholas Singewald
36. Distinct Neural Mechanisms Underlying Fear and Anxiety
Joseph LeDoux
37. Synaptic and Circuit Mechanisms of Anxiety Disorders: Animal and Human Studies
Anfei Li, Francis S. Lee
38. The Neurobiology of Resilience
Adriana Feder, Sarah R. Horn, Margaret Haglund, Steven M. Southwick, and Dennis S. Charney
39. Novel Approaches for Treating Anxiety Disorders
David A. Sturman,Milissa L. Kaufman, Cara E. Bigony, and Kerry J. Ressler
40. Novel treatment approaches for anxiety disorders
Adam J. Guastella, Alice Norton, Gail A. Alvares, and Christine Song
Section 5: Substance Use Disorders
41. Epidemiology of Substance Use Disorders
Denise B. Kandel, Mei-Chen Hu, Pamela C. Griesler, Bradley T. Kerridge, and Bridget F. Grant
42. The Genetic Basis of Addictive Disorders
David Goldman, Zhifeng Zhou, and Colin Hodgkinson
43. Animal Models of Addiction
Christopher Evans J., Brigitte L. Lieffer, David Jentsch, and Rafael J. Maldonado
44. Reward Circuitry and Drug Addiction
Vaughn R. Steele, Vani Pariyadath, Rita Z. Goldstein, and Elliot A. Stein
45. Molecular Neuroimaging in Addictive Disorders
Edythe D. London and Chelsea L. Robertson
46. Cellular and Molecular Mechanisms of Addiction
Kathryn J. Reissner and Peter W. Kalivas
47. Brain Development and the Risk for Substance Abuse
Mary M. Heitzeg and B.J. Casey
48. Pharmacotherapy of Substance Use Disorders
Jane B. Acri and Phil Skolnick
49. Current Approved Pharmacotherapies for Substance Use Disorders
Alexis S. Hammond and Eric C. Strain
Section 6: Dementia
50. Diagnosis and Epidemiology of Dementia
William C. Kreisl and Christiane Reitz
51. Genetics of Dementia
Alan E. Renton and Alison M. Goate
52. Neuroimaging and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease
Brian A. Gordon, Stephanie J.B. Vos, and Anne M. Fagan
53. Animal Models of Alzheimer's Disease
David Morgan
54. Cellular Mechanisms of Dementia: Animal and Human Studies
Li Gan
55. Neurobiology of Lewy Body Dementias: Animal and Human Studies
James E. Galvin and Jose Tomas Bras
56. Neurobiology of FTD: Animal and Human Studies
Dah-eun Chloe Chung, Jeannette N. Stankowski, and Leonard Petrucelli
57. Current Treatments for Alzheimer's Disease
Mary Sano and Judith Neugroschil
Section 7: Psychiatric Disorders of Childhood Onset
58. Diagnosis and Epidemiology of Pediatric Psychiatric Disorders of Childhood
Elise Robinson, Benjamin Neale, and Mark Daly
59. Genetics of Pediatric Psychiatric Disorders
Silvia de Rubeis, M. Pilar Trelles, and Joseph D. Buxbaum
60. Neuroimaging in Pediatric Psychiatric Disorder
Timothy P.L. Roberts and Luke Bloy
61. Animal and Cellular Models of Pediatric Psychiatric Disorders
Elodie Drapeau, Hala Harony-Nicolas, and Jacqueline N. Crawley
62. Neurodevelopmental Mechanisms of Pediatric Psychiatric Disorders: Animal and Human Studies
Silvia De Rubeis, Kathryn Roeder, and Bernie Devlin
63. Neurobiology of Autism Spectrum Disorder and Intellectual Disability: Animal and Human Studies
Jesse Costales, Silvia De Rubeis, Jennifer Foss-Feig, Patrick Hof, Joseph D. Buxbaum, and Alexander Kolezvon
64. Neurobiology of Attention Deficit Hyperactivity Disorder: Animal and Human Studies
Stephen V. Faraone, Pradeep G. Bhide, and Joseph Biederman
65. The Neurobiology of Tic Disorders and Obsessive-Compulsive Disorder: Human and Animal Studies
Christopher Pittenger
66. Neurobiology of Eating Disorders: Animal and Human Studies
Thomas Hildebrandt and Ashley Heywood
67. Novel Approaches for Treating Pediatric Psychiatric Disorders
Supritha Prasad and Edwin H. Cook, Jr.
68. Current Treatments for Pediatric Psychiatric Disorders
M. Pilar Trelles, Paige Siper, and Dorothy Grice
Section 8: Future of Psychiatric Diagnosis: Toward Precision Psychiatry
69. DSM-5® Overview and Goals
Darrel A. Regier, Sarah E. Morris, and Susan K. Schulz
70. The Present and Future of Psychiatric Diagnosis
Steven E. Hyman
71. The NIMN Research Domain Criteria Project: Toward Precision Medicine in Psychiatry
Bruce N. Cuthbert
72. Computational Psychiatry and the Bayesian Brain
Karl J. Friston and Raymond J. Dolan

Charney & Nestler's Neurobiology of Mental Illness

Fifth edition

Edited by Dennis S. Charney,MD , Eric J. Nestler,MD, PhD , Pamela Sklar,MD, PhD , and Joseph D. Buxbaum,PhD

Author Information

Edited by Dennis S. Charney, MD, Anne and Joel Ehrenkranz Dean, Icahn School of Medicine at Mount Sinai, Edited by Eric J. Nestler, MD, PhD, Nash Family Professor of Neuroscience and Director of the Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, Edited by Pamela Sklar, MD, PhD, Chief of the Division of Psychiatric Genomics; Professor of Psychiatry, Neurosciance, and Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, and Edited by Joseph D. Buxbaum, PhD, Professor of Psychiatry, Neurosciance, and Genetics and Genomic Sciences; Director of the Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai

Dennis S. Charney, MD Anne and Joel Ehrenkranz, Dean, Icahn School of Medicine at Mount Sinai President for Academic Affairs Mount Sinai Health System Professor, Departments of Psychiatry, Neuroscience, and Pharmacological Sciences New York, NY

Joseph D. Buxbaum, PhD G. Harold and Leila Y. Mathers Professor, Departments of Psychiatry, Neuroscience, and Genetics and Genomic Sciences Deputy chair, department of psychiatry Director, Seaver Autism Center for research and treatment Icahn School of Medicine at Mount Sinai New York, NY

Pamela Sklar, MD, PhD Mount Sinai professor of Psychiatric genomics Chair, department of Genetics and Genomic Sciences Professor, Departments of Genetics and Genomic Sciences, Psychiatry, Neuroscience, and Director, Center for Psychiatric Genomics Icahn School of Medicine at Mount Sinai New York, NY

Eric J. Nestler, MD, PhD Nash Family Professor Departments of Neuroscience and Psychiatry Director, The Friedman Brain Institute Dean for academic and scientific affairs Icahn School of Medicine at Mount Sinai New York, NY

Contributors:

Jane B. Acri, PhD
Chief, Medication Discovery & Toxicology Branch
Division of Therapeutics & Medical Consequences
National Institute on Drug Abuse
National Institutes of Health
Bethesda, Maryland

Lyonna F. Alcantara, MS
Department of Psychology
Texas A&M University
College Station, Texas

Gail A. Alvares, PhD
Brain and Mind Centre
Sydney Medical School
University of Sydney
Sydney, New South Wales, Australia

Alan Anticevic, PhD
Department of Psychiatry
Yale University School of Medicine
NIAAA Center for the Translational Neuroscience of Alcoholism
Abraham Ribicoff Research Facilities
Connecticut Mental Health Center
New Haven, Connecticut

Schahram Akbarian, MD, PhD
Friedman Brain Institute
Departments of Psychiatry and Neuroscience
Icahn School of Medicine
Mount Sinai
New York, New York

Peter A. Bandettini, PhD
Principal Investigator
National Institutes of Mental Health
Bethesda, Maryland

Deanna M. Barch, PhD
Department of Psychological & Brain Sciences
Department of Psychiatry
Department of Radiology
Washington University in St. Louis
St. Louis, Missouri

Mandakh Bekhbat, BA
Department of Physiology
Emory University School of Medicine
Atlanta, Georgia

Michele A. Bertocci, PhD
Department of Psychiatry
University of Pittsburgh
Western Psychiatric Institute and Clinic
Pittsburgh, Pennsylvania

Joseph Biederman, MD
Pediatric Psychopharmacology Unit
Child Psychiatry Service
Massachusetts General Hospital
Harvard Medical School
Boston, Massachusetts

Pradeep G. Bhide, PhD
Florida State University College of Medicine
Pediatric Psychopharmacology Unit of the Child Psychiatry Service
Tallahassee, Florida

Cara E. Bigony, BA
Department of Psychiatry
McLean Hospital
Harvard Medical School
Belmont, Massachusetts

Luke Bloy, PhD
Lurie Family Foundations MEG Imaging Center
Department of Radiology
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania

Carlos A. Bolaños-Guzmán, PhD
Department of Psychology
Texas A&M University
College Station, Texas

Ryan Bowman
Department of Psychiatry
Duke University School of Medicine
Durham, North Carolina

Jose Tomas Bras, PhD
Department of Molecular Neuroscience
UCL, Institute of Neurology

Kristen Brennand, PhD
Associate Professor
Genetics and Genomic Sciences, Neuroscience, Psychiatry
Icahn School of Medicine at Mount Sinai
New York, New York

Katherine E. Burdick, PhD
Professor of Psychiatry and Neuroscience
Mount Sinai School of Medicine
New York, New York

Richard E. Carson, PhD
Department of Radiology and Biomedical Imaging
Department of Biomedical Engineering
Yale University
New Haven, Connecticut

B.J. Casey, PhD
Professor of Psychology
Yale University
New Haven, Connecticut

Sara Cherkerzian, SCD
Departments of Psychiatry and Medicine
Harvard Medical School
Brigham and Women's Hospital
Connors Center for Women's Health & Gender Biology
Boston, Massachusetts

Chiara Cirelli, PhD
Professor, Department of Psychiatry
Neuroscience Training Program
University of Wisconsin-Madison
Madison, Wisconsin

Andrew Chess, MD
Department of Developmental and Regenerative Biology
Icahn School of Medicine
Mount Sinai
New York, New York

Dah-eun Chloe Chung, BA
Department of Neuroscience
Mayo Clinic
Neurobiology of Disease
Mayo Clinic Graduate School of Biomedical Sciences
Rochester, Maine

Edwin H. Cook, Jr, MD, IJR
Department of Psychiatry
University of Illinois at Chicago
Chicago, Illinois

Kelly P. Cosgrove, PhD
Department of Radiology and Biomedical Imaging
Department of Psychiatry
Yale University
New Haven, Connecticut

Jesse Costales, MD
Seaver Autism Center for Research and Treatment
Departments of Psychiatry and Neuroscience
Icahn School of Medicine at Mount Sinai
New York, New York

Jacqueline N. Crawley, PhD
Robert E. Chason Endowed Chair in Translational Research
MIND Institute
Professor, Department of Psychiatry and Behavioral Neuroscience
University of California Davis School of Medicine
Sacramento, California

Bruce N. Cuthbert, PhD
Department of Psychiatry
University of Pittsburgh
Pittsburgh, Pennsylvania

Mark Daly, PhD
Analytic and Translational Genetics Unit
Massachusetts General Hospital
Program in Medical and Population Genetics
Broad Institute of MIT and Harvard
Boston, Massachusetts

Bernie Devlin, PhD
Department of Statistics
Carnegie Mellon University
Department of Psychiatry
University of Pittsburgh School of Medicine
Pittsburgh, Pennsylvania

Silvia de Rubeis, PhD
Seaver Autism Center for Research and Treatment
Department of Psychiatry
Icahn School of Medicine at Mount Sinai
New York, New York

Samuel J. Dienel, MD
Department of Psychiatry
University of Pittsburgh
Pittsburgh, Pennsylvania

Karl Deisseroth, MD, PhD
Howard Hughes Medical Institute
Departments of Bioengineering and Psychiatry
Stanford University
Stanford, California

Raymond J. Dolan, FRS
Wellcome Trust Centre for Neuroimaging
Institute of Neurology
University College London
London, England, UK

Elodie Drapeau, PhD
Seaver Autism Center for Research and Treatment
Department of Psychiatry
Friedman Brain Institute
Icahn School of Medicine at Mount Sinai
New York, New York

Ronald S. Duman, PhD
Laboratory of Molecular Psychiatry
Departments of Psychiatry and Pharmacology
Yale University School of Medicine
Connecticut Mental Health Center
New Haven, Connecticut

Kafui Dzirasa, MD, PhD
Department of Psychiatry
Duke University School of Medicine
Durham, North Carolina

Amit Etkin, MD, PhD
Associate Professor of Psychiatry and Behavioral Sciences
Stanford University School of Medicine
Stanford, California

Christopher J. Evans, PhD
UCLA Brain Research Institute
University of California, Los Angeles
Los Angeles, California

Anne M. Fagan, PhD
The Knight Alzheimer's Disease Research Center
Department of Neurology
Washington University in St. Louis
St. Louis, Missouri

Stephen V. Faraone, PhD
Department of Psychiatry
SUNY Upstate Medical University
Center for Brain Repair
Department of Biomedical Sciences
Syracuse, New York

Adriana Feder, MD
Associate Professor of Psychiatry
Associate Director for Research
World Trade Center Mental Health Program
Icahn School of Medicine at Mount Sinai
New York, New York

Lief E. Fenno, MD, PhD
Howard Hughes Medical Institute
Departments of Bioengineering and Psychiatry
Stanford University
Stanford, California

Jennifer Foss-Feig, PhD
Seaver Autism Center for Research and Treatment
Departments of Psychiatry and Neuroscience
Icahn School of Medicine at Mount Sinai
New York, New York

Karl J. Friston, FRS, FMedSci, FRSB
Wellcome Trust Centre for Neuroimaging
Institute of Neurology
University College London
London, England, UK

Nao J. Gamo, PhD
Department of Psychiatry and Behavioral Sciences
Johns Hopkins University School of Medicine
Baltimore, Maryland

Li Gan, PhD
Gladstone Institutes
University of California, San Francisco
San Francisco, California

James E. Galvin, MD, MPH
Comprehensive Center for Brain Health
Charles E. Schmidt College of Medicine
Florida Atlantic University
Boca Raton, Florida

Mark S. George, MD
Departments of Psychiatry, Radiology, and Neuroscience
Medical University of South Carolina
Ralph H. Johnson VA Medical Center
Charleston, South Carolina

Alison M. Goate, D.Phil
Ronald M. Loeb Center for Alzheimer's Disease
Department of Neuroscience
Icahn School of Medicine at Mount Sinai
New York, New York

David Goldman, MD
Clinical Assistant Professor
Department of Psychiatry
NYU Langone Health
New York University
New York, New York

Jill M. Goldstein, PhD
Departments of Psychiatry and Medicine
Harvard Medical School
Brigham and Women's Hospital
Connors Center for Women's Health & Gender Biology
BWH, departments of Psychiatry and Medicine
Boston, Massachusetts

Rita Z. Goldstein, PhD
Departments of Psychiatry & Neuroscience
Icahn School of Medicine at Mount Sinai
New York, New York

Madeleine S. Goodkind, PhD
University of California, Berkeley
Berkeley, California

Wayne K. Goodman, MD
Menninger Department of Psychiatry and Behavioral Sciences
Baylor College of Medicine
Houston, Texas

Brian A. Gordon, PhD
Department of Radiology
The Knight Alzheimer's Disease Research Center
Washington University in St. Louis
St. Louis, Missouri

Bridget F. Grant, PhD
National Institutes of Health
Bethesda, Maryland

Seth G. N. Grant
Centre for Clinical Brain Sciences
The University of Edinburgh
Edinburgh, Scotland, UK

Dorothy Grice, MD
Division of Tics, OCD and Other Related Disorders
Department of Psychiatry
Icahn School of Medicine at Mount Sinai
New York, New York

Pamela C. Griesler
Department of Psychiatry
Mailman School of Public Health
Columbia University School of Medicine
New York, New York

Adam J. Guastella, PhD
Brain and Mind Centre
Sydney Medical School
University of Sydney
Sydney, New South Wales, Australia

Stephen J. Haggarty, PhD
Associate Professor
Department of Neurology
Harvard Medical School
Boston, Massachusetts

Margaret Haglund, MD
Department of Psychiatry & Behavioral Neurosciences
Cedars-Sinai Medical Group
Beverly Hills, California

Alexis S. Hammond, MD, PhD
Behavioral Pharmacology Research Unit
Department of Psychiatry and Behavioral Sciences
Johns Hopkins University School of Medicine
Baltimore, Maryland

R.J. Handra, PhD
Department of Biomedical Sciences
Colorado State University
Fort Collins, Colorado

Hala Harony-Nicolas, PhD
Seaver Autism Center for Research and Treatment
Department of Psychiatry
Friedman Brain Institute
Icahn School of Medicine at Mount Sinai
New York, New York

Stephan Heckers, MD
Director, Vanderbilt Early Psychosis Program
Department of Psychiatry
Vanderbilt University Medical Center
Nashville, Tennessee

Mary M. Heitzeg, PhD
Department of Psychiatry
University of Michigan
Ann Arbor, Michigan

John M. Hettema, MD, PhD
Department of Psychiatry
Virginia Institute for Psychiatric and Behavioral Genetics
Virginia Commonwealth University
Richmond, Virginia

Ashley Heywood, BS
Icahn School of Medicine at Mount Sinai
New York, New York

Thomas Hildebrandt, PsyD
Icahn School of Medicine at Mount Sinai
New York, New York

Ansel T. Hillmer, PhD
Department of Radiology and Biomedical Imaging
Department of Psychiatry
Yale University
New Haven, Connecticut

Georgia E. Hodes, PhD
Fishberg Department of Neuroscience
Friedman Brain Institute
Icahn School of Medicine
Mount Sinai
New York, New York

Colin Hodgkinson, PhD
Section of Human Neurogenetics
National Institute on Alcohol Abuse and Alcoholism
National Institutes of Health
Bethesda, Maryland

Patrick Hof, MD
Seaver Autism Center for Research and Treatment
Departments of Psychiatry and Neuroscience
Icahn School of Medicine at Mount Sinai
New York, New York

L. Holsen, PhD
Departments of Psychiatry and Medicine
Harvard Medical School
Brigham and Women's Hospital
Connors Center for Women's Health & Gender Biology
BWH, departments of Psychiatry and Medicine
Boston, Massachusetts

Sarah R. Horn
Department of Psychology
University of Oregon
Eugene, Oregon

Mei-Chen Hu, PhD
Associate Research Scientist
Department of Psychiatry
Columbia University Medical Center
New York, New York

Rainbo Hultman, PhD
Department of Psychiatry
Duke University School of Medicine
Durham, North Carolina

Steven E. Hyman, MD
Director, Stanley Center for Psychiatric Research
Broad Institute of MIT and Harvard
Boston, Massachusetts

Brian M. Iacoviello, PhD
Mood and Anxiety Disorders Program
Department of Psychiatry
Icahn School of Medicine
Mount Sinai
New York, New York

Hanna Jaaro-Peled, PhD
Department of Psychiatry and Behavioral Sciences
Johns Hopkins University School of Medicine
Baltimore, Maryland

David Jentsch, PhD
Professor of Psychiatry
Binghamton University, State University of New York
Binghamton, New York

Peter W. Kalivas, PhD
Department of Neurosciences
Medical University of South Carolina
Charleston, South Carolina

Shitij Kapur, FRCPC, PhD, FMedSci
Dean, Faculty of Medicine, Dentistry, and Health Sciences
Assistant Vice-Chancellor (Health)
University of Melbourne
Melbourne, Victoria, Australia

Milissa L. Kaufman, MD, PhD
Department of Psychiatry
McLean Hospital
Harvard Medical School
Belmont, Massachusetts

Bradley T. Kerridge, MD
National Institutes of Health
Bethesda, Maryland

Brigitte L. Kieffer, PhD
Scientific Director
Douglas Institute Professor
Department of Psychiatry
McGill University Chair
McGill University
Montreal, Canada

Alexander Kolezvon, MD
Seaver Autism Center for Research and Treatment
Departments of Psychiatry and Neuroscience
Icahn School of Medicine at Mount Sinai
New York, New York

Meghan E. Keough, PhD
University of Washington, Seattle
Seattle, Washington

William C. Kreisl, MD
Taub Institute for Research on Alzheimer's Disease and the Aging Brain
Department of Neurology
College of Physicians and Surgeons
Columbia University
New York, New York

John H. Krystal, MD
Departments of Psychiatry and Neuroscience
Yale University School of Medicine
Behavioral Health services
New Haven Hospital
New Haven, Connecticut
Clinical Neuroscience Division
VA National Center for PTSD
VA Connecticut Healthcare System
West Haven, Connecticut

Joseph LeDoux, PhD
New York University
New York, New York

Francis S. Lee, MD, PhD
Sackler Institute for Developmental Psychobiology
Weill Cornell Medical College of Cornell University
New York, New York

Douglas F. Levinson, MD
Professor of Psychiatry
Department of Psychiatry
Stanford University
Palo Alto, California

David A. Lewis, MD
Department of Psychiatry
University of Pittsburgh
Pittsburgh, Pennsylvania

Anfei Li
Sackler Institute for Developmental Psychobiology
Department of Psychiatry
Weill Cornell Medical College of Cornell University
New York, New York

Edythe D. London, PhD
Department of Molecular and Medical Pharmacology
Department of Psychiatry and Biobehavioral Sciences
David Geffen School of Medicine
Brain Research Institute
University of California Los Angeles
Los Angeles, California

Hanzhang Lu, PhD
Professor of Radiology and Radiological Science
Johns Hopkins University School of Medicine
Baltimore, Maryland

Dolores Malaspina, MD
Department of Psychiatry
Columbia University Medical Center
New York, New York

Rafael J. Maldonado, MD, PhD
Department of Experimental and Health Sciences
University Pompeu Fabra
Barcelona, Catalunya, Spain

Anil K. Malhotra, MD
Professor, The Center for Psychiatric Neuroscience
The Feinstein Institute for Medical Research
Director, Psychiatry Research
Zucker Hillside Hospital
Professor, Molecular Medicine and Psychiatry
Hofstra Northwell School of Medicine
New York, New York

Tiago Reis Marks, MD, PhD
Department of Psychosis Studies
King's College London
London, England, UK

Caroline Ménard, PhD
Fishberg Department of Neuroscience
Friedman Brain Institute
Icahn School of Medicine at Mount Sinai
New York, New York

Emma Meyer, MD
Department of Psychiatry
New York University School of Medicine
New York, New York

Guo-Li Ming, MD, PhD
Johns Hopkins University School of Medicine
Baltimore, Maryland

M. Misra, MD, MPH
Departments of Psychiatry and Medicine
Harvard Medical School
Brigham and Women's Hospital
Connors Center for Women's Health & Gender Biology
BWH, departments of Psychiatry and Medicine
Boston, Massachusetts

Lisa M. Monteggia, PhD
Department of Neuroscience
UT Southwestern Medical Center
Dallas, Texas

David Morgan, PhD
CEO, Byrd Alzheimer's Institute
Distinguished Professor of Pharmacology and Physiology
University of South Florida
Tampa, Florida

James W. Murrough, MD
Mood and Anxiety Disorders Program
Department of Psychiatry
Fishberg Department of Neuroscience
Friedman Brain Institute
Icahn School of Medicine
Mount Sinai
New York, New York

Benjamin Neale, PhD
Analytic and Translational Genetics Unit
Massachusetts General Hospital
Program in Medical and Population Genetics
Broad Institute of MIT and Harvard
Stanley Center for Psychiatric Research
Broad Institute of MIT and Harvard
Boston, Massachusetts

Gretchen N. Neigh, PhD
Departments of Anatomy and Neurobiology
Virginia Commonwealth University
Richmond, Virginia

Judith Neugroschil, MD
Alzheimer's Disease Research Center
Icahn School of Medicine at Mount Sinai
New York, New York

Walter E. Nichols, MD
Professor in the School of Medicine
Department of Psychiatry
Program on the Genetics of Brain Function
Stanford University
Palo Alto, California

Alice Norton, PhD
Brain and Mind Centre
Sydney Medical School
University of Sydney
Sydney, New South Wales, Australia

Dost Öngür, MD, PhD
Chief, Psychotic Disorders Division
Director, Schizophrenia and Bipolar Disorder Research Program
McLean Hospital
Associate Professor of Psychiatry
Harvard Medical School
Boston, Massachusetts

Luz H. Ospina, MA, PhD
Icahn School of Medicine at Mount Sinai
New York, New York

Takeshi Otowa, MD, PhD
Graduate School of Clinical Psychology
Teikyo Heisei University
Tokyo, Japan

Eric M. Parise, PhD
Fishberg Department of Neuroscience
The Mount Sinai School of Medicine
New York, New York

Vani Pariyadath, PhD
National Institute on Drug Abuse
Bethesda, Maryland

Roy H. Perlis, MD, MSc
Professor of Psychiatry
Harvard Medical School
Director, Center for Experimental Drugs and Diagnostics
Center for Genomic Medicine
Massachusetts General Hospital
Boston, Massachusetts

Leonard Petrucelli, PhD
Department of Research, Neuroscience
Mayo Clinic College of Medicine
Jacksonville, Florida

Madeline L. Pfau, PhD
Fishberg Department of Neuroscience
Friedman Brain Institute
Icahn School of Medicine
Mount Sinai
New York, New York

Mary L. Philips, MD
Department of Psychiatry
University of Pittsburgh
Western Psychiatric Institute and Clinic
Pittsburgh, Pennsylvania

Christopher Pittenger, MD, PhD
Department of Psychiatry
Yale University
New Haven, Connecticut

Mikhail V. Pletnikov, MD, PhD
Johns Hopkins University School of Medicine
Baltimore, Maryland

Supritha Prasad, IJR
Department of Psychiatry
University of Illinois at Chicago
Chicago, Illinois

Shaun M. Purcell, PhD
Associate Professor, Psychiatry
Associate Professor, Genetics and Genomic Sciences
Icahn School of Medicine at Mount Sinai
New York, New York

Darrel A. Regier, MD, MPH
Center for the Study of Traumatic Stress
Department of Psychiatry
Uniformed Services University
Bethesda, Maryland

Kathryn J. Reissner, PhD
Department of Psychology & Neuroscience
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina

Christiane Reitz, MD, PhD
Taub Institute for Research on Alzheimer's Disease and the Aging Brain
Department of Neurology
Gertrude H. Sergievsky Center
Department of Epidemiology
Mailman School of Public Health
College of Physicians and Surgeons
Columbia University
New York, New York

Alan E. Renton, PhD
Ronald M. Loeb Center for Alzheimer's Disease
Department of Neuroscience
Icahn School of Medicine at Mount Sinai
New York, New York

Kerry J. Ressler, MD, PhD
Department of Psychiatry
McLean Hospital
Harvard Medical School
Belmont, Massachusetts
Department of Psychiatry and Behavioral Sciences
Emory University School of Medicine
Atlanta, Georgia

Roxann Roberson-Nay, PhD
Departments of Psychiatry and Psychology
Virginia Institute for Psychiatric and Behavioral Genetics
Virginia Commonwealth University
Richmond, Virginia

Timothy P.L. Roberts, PhD
Lurie Family Foundations MEG Imaging Center
Department of Radiology
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania

Chelsea L. Robertson, PhD
Department of Molecular and Medical Pharmacology
Department of Psychiatry and Biobehavioral Sciences
David Geffen School of Medicine
University of California Los Angeles
Los Angeles, California

Elise Robinson, ScD
Analytic and Translational Genetics Unit
Massachusetts General Hospital
Boston, Massachusetts

Kathryn Roeder, PhD
Computational Biology Department
Carnegie Mellon University
Pittsburgh, Pennsylvania

Christopher A. Ross, MD
Johns Hopkins University School of Medicine
Baltimore, Maryland

Peter P. Roy-Byrne, MD
Professor Emeritus, Department of Psychiatry
University of Washington School of Medicine
Seattle, Washington

Scott J. Russo, PhD
Fishberg Department of Neuroscience
Friedman Brain Institute
Icahn School of Medicine
Mount Sinai
New York, New York

Takeshi Sakurai, MD, PhD
Department of Drug Discovery Medicine
Medical Innovation Center
Kyoto University Graduate School of Medicine
Kyoto, Japan

Mary Sano, PhD
Alzheimer's Disease Research Center
Icahn School of Medicine at Mount Sinai
New York, New York
James J. Peters VAMC
Bronx, New York

Deepak K. Sarpal, MD
Assistant Professor of Psychiatry
Department of Psychiatry
University of Pittsburgh
Pittsburgh, Pennsylvania

Akira Sawa, MD, PhD
Department of Psychiatry and Behavioral Sciences
Johns Hopkins University School of Medicine
Baltimore, Maryland

Eric E. Schadt, PhD
Department of Genetics and Genomic Sciences
Mount Sinai School of Medicine
New York, New York

Hannah Schwennesen, MD
Department of Psychiatry
Duke University School of Medicine
Durham, North Carolina

Nicholas Singewald, PhD
Department of Pharmacology and Toxicology
Inst. Pharmacy and CMBI
University of Innsbruck
Innsbruck, Austria

Paige Siper, PhD
Seaver Autism Center for Research and Treatment
Department of Psychiatry
Icahn School of Medicine at Mount Sinai
New York, New York

Phil Skolnick, PhD, DSC (Hon)
Director
Division of Therapeutics & Medical Consequences
National Institute on Drug Abuse
National Institutes of Health
Bethesda, Maryland

Christine Song, PhD
Brain and Mind Centre
Sydney Medical School
University of Sydney
Sydney, New South Wales, Australia

Steven M. Southwick, MD
Glenn H. Greenberg Professor of Psychiatry
Yale University School of Medicine
New Haven, Connecticut

Vaughn R. Steele, PhD
Neuroimaging Research Branch
National Institute of Drug Abuse
Intramural Research Program
National Institutes of Health
Baltimore, Maryland

Elliot A. Stein, PhD
Neuroimaging Research Branch
National Institute of Drug Abuse
Intramural Research Program
National Institutes of Health
Baltimore, Maryland

Murray B. Stein, MD, MPH, FRCPC
Distinguished Professor, Psychiatry
Distinguished Professor, Family Medicine and Public Health
Vice Chair for Clinical Research in Psychiatry
University of California, San Diego
San Diego, California

Eric C. Strain, MD
Behavioral Pharmacology Research Unit
Department of Psychiatry and Behavioral Sciences
Johns Hopkins University School of Medicine
Baltimore, Maryland

Jeannette N. Stankowski, PhD
Department of Neuroscience
Mayo Clinic College of Medicine
Jacksonville, Florida

David A. Sturman, MD, PhD
Department of Psychiatry
McLean Hospital
Harvard Medical School
Belmont, Massachusetts
MGH/McLean Adult Psychiatry Residency Program
Harvard Medical School
Boston, Massachusetts

Ramon Tasan, PhD
Department of Pharmacology
Medical University Innsbruck
Innsbruck, Austria

Giulio Tononi, MD, PhD
Professor, Department of Psychiatry
Neuroscience Training Program
University of Wisconsin-Madison
Madison, Wisconsin

M. Pilar Trelles, MD
Seaver Autism Center for Research and Treatment
Department of Psychiatry
Icahn School of Medicine at Mount Sinai
New York, New York

Nicholas T. Van Dam, PhD
Mood and Anxiety Disorders Program
Department of Psychiatry
Icahn School of Medicine
Mount Sinai
New York, New York

Stephanie J.B. Vos, PhD
Department of Psychiatry and Neuropsychology
Alzheimer Center Limburg
School for Mental Health and Neuroscience
Maastricht University
Maastricht, the Netherlands

Julie Walsh-Messinger, MA, PhD
Assistant Professor
Department of Psychiatry
University of Dayton
Dayton, Ohio

Neil Woodward, PhD
Vanderbilt Early Psychosis Program
Department of Psychiatry
Vanderbilt University Medical Center
Nashville, Tennessee

Wei Xu, PhD
Department of Neuroscience
UT Southwestern Medical Center
Dallas, Texas

Jared Young, PhD
Department of Psychiatry
University of California San Diego
La Jolla, California
Desert-Pacific Mental Illness Research Education and Clinical Center
VA San Diego Healthcare System
San Diego, California

Zijia Zhang, PhD
Oklahoma State University
Center for Health Sciences
Tulsa, Oklahoma

Zhifeng Zhou, PhD
Section of Human Neurogenetics
National Institute on Alcohol Abuse and Alcoholism
Bethesda, Maryland