Challenging Concepts in Infectious Diseases and Clinical Microbiology

Cases with Expert Commentary

Edited by Amber Arnold and George Griffin

Challenging Concepts

A case-based guide to challenging cases in infectious diseases and microbiology, helping doctors to manage complex situations
'Learning points', 'Clinical tips', and 'Evidence based' boxes highlight critical information, facilitating learning and aiding revision
The 'Expert commentary' gives a unique insight into how today's opinion leaders confront and deal with these complex cases

Challenging Concepts in Infectious Diseases and Clinical Microbiology

Cases with Expert Commentary

Edited by Amber Arnold and George Griffin

Description

Challenging Concepts in Infectious Diseases and Clinical Microbiology details over 30 challenging cases from a wide area of infectious diseases, medical microbiology and virology and includes topics ranging from typhoid fever to secondary syphilis.

This case-based learning book ideal for trainees and speciality registrars. Each case is supported by the commentary of a renowned expert in the field, allowing readers to improve their own management of these patients.

As the reader works through each case there are 'Clinical Tips', 'Learning Points' and 'Evidence Base' boxes to enhance the learning process along with the 'Expert Commentary', providing an inside track on how the experts approach challenging cases ranging from secondary syphilis to typhoid fever and vial haemorrhagic fever.

Challenging Concepts in Infectious Diseases and Clinical Microbiology

Cases with Expert Commentary

Edited by Amber Arnold and George Griffin

Challenging Concepts

1:Pyrexia of unknown origin: the use of PET and PET-CT, Neill Storrar and Chantal Bleeker-Rovers
2:Neurological Complications of Lyme Borreliosis (LB), Victoria Sing-Curry, Amber Arnold and Sue O'Connell
3:Leptospirosis and its Complications, Nick Easom, Amber Arnold and David Moore
4:Secondary Syphilis, Angela Houston and Patrick French
5:HIV-Associated Multicentric Castleman's Disease, Michael Rayment and Mark Bower
6:HIV: Prevention of Mother to Child Transmission, Aseel Hegazi and Phillip Hay
7:HIV: Antiretroviral Treatment and Emergence of Resistance, Daniel Bradshaw, Amber Arnold and Andrew Carr
8:HIV: opportunistic infections and immune reconstitution syndrome, Ellen Dwyer, Amber Arnold and Derek Macallan
9:HIV: Cryptococcal Meningitis and Timing of Antiretroviral Treatment, Angela Loyse and Tom Harrison
10:Candida Infection in the Intensive Care Unit, Luke Moore and Silke Schelenz
11:Disseminated Aspergillosis after Bone Marrow Transplantation, Jonathon Lambourne and Caroline Hemsley
12: Hepatitis B Reactivation in the Immunosuppressed, Gyatri Chakrabati and Daniel Forton
13:Developments in the Treatment of Hepatitis C Virus Infection, Thomas Doyle and Daniel Webster
14:Management of Viral Haemorrhagic Fevers in the UK, Jonathon Lambourne and Tim Brooks
15:Tropical Liver Abscess: Diagnosis and Management, Marcus Eder, Amber Arnold and Elinor Moore
16:Severe Falciparum Malaria: Treatment Options in the UK, Marcus Eder, Amber Arnold and Elinor Moore
17:Imported Plasmodium Vivax, Emily Wise and Tom Doherty
18:Typhoid Fever: Antibiotic Treatment Choices, Nick Feasey and Chris Parry
19:Hospital Acquired Legionella Pneumonia, Catherine Roberts and William Newsholme
20:Severe Clostridium Difficile Infection (CDI), Jasmine Islam and Martin Llwellyn
21:Staphylococcal Prosthetic Joint Infection, Kate El Bouzidi and Mathew Laundy
22:Methicillin Resistant Staphylococcus Aureus (MRSA) Bacteraemia, James Price and Martin Llwellyn
23:Pneumococcal Meningitis: Antibiotic Options for Resistant Organisms, Sathyavani Subbarao and Claire Thomas
24:Urinary Sepsis: Vancomycin-Resistant Enterococci (VRE), Julia Howard and Sorrush Soleimanian
25:Disseminated Nocardiosis, Amber Arnold, Jayne Ellis and Robert Hill
26:Urinary Sepsis: Extended Spectrum Beta Lactamase Producing (ESBL) E. coli, Rishi Dhillon, Amber Arnold and Hugo Donaldson
27:Multi-Drug Resistant Pseudomonas Aeruginosa Infection in Cystic Fibrosis, James Hatcher and Michael Loebinger
28:The Treatment of Mycobacterium Abscessus Lung Disease, Maryam Mirfenderesky and David E. Griffith
29:Multi-Drug Resistant Tuberculosis, Caoimhe Gogarty and Mike Brown
30:Diagnostic and Management Issues in Tuberculous Meningitis, Naghum Dawood and Catherine Cosgrove
31:Treated Pulmonary Tuberculous Complicated by Sarcoidosis, Georgina Russell, Sally O'Connor and Felix Chua

Challenging Concepts in Infectious Diseases and Clinical Microbiology

Cases with Expert Commentary

Edited by Amber Arnold and George Griffin

Challenging Concepts

Author Information

Edited by Amber Arnold, Specialty Registrar in Infectious Diseases and Medical Microbiology, St George's Hospital, London, UK, and George Griffin, Consultant in Infectious Diseases, St George's Hospital, London, UK

Contributors:

Experts

Chantal Bleeker-Rovers
Department of Internal Medicine
Radboud University Medical Centre in Nijmegen
The Netherlands

Mark Bower
Professor of Oncology
Chelsea and Westminster Hospital NHS Foundation Trust and
Imperial College London, UK

Tim Brooks
Head of Rare and Imported Pathogens Laboratory
PHE Microbiology Services Porton
Porton Down, UK

Mike Brown
Clinical Senior Lecturer and
Consultant Physician
London school of Hygiene and Tropical
Medicine and

Hospital for Tropical Diseases at University College London Hospital
London, UK

Andrew Carr
Professor of Medicine
University of New South Wales and
Head, HIV, Immunology and Infectious Diseases Unit and
Head, Clinical Research Program
Centre for Applied Medical Research
Sydney, Australia

Felix Chua
Consultant Respiratory and General Physician and
Honorary Senior Lecturer (SGUL)
St. Georgeâs Healthcare NHS Trust
London, UK

Catherine Cosgrove
Consultant Physician Infectious Diseases
and Acute Medicine
St. Georgeâs Healthcare NHS Trust
London, UK

Tom Doherty
Consultant in Infectious Diseases and
Tropical Medicine
University College London Hospital NHS Trust
London, UK

Hugo Donaldson
Consultant Medical Microbiologist
Imperial College Healthcare NHS Trust
London, UK

Daniel Forton
Consultant Hepatologist and Honorary
Senior Lecturer
St Georgeâs Healthcare NHS Trust
London, UK

Patrick French
Consultant Physician in Genitourinary Medicine
The Mortimer Market Centre
London, UK

David E. Griffith
Professor of Medicine
Pulmonary and Critical Care Division Chief
The University of Texas Health Sciences Center
Texas, USA

Tom Harrison
Professor of Infectious Diseases and Medicine
and Joint Head of The Infection And Immunity Research Centre
St Georgeâs Healthcare NHS Trust
London, UK

Phillip Hay
Reader and Honorary Consultant
St Georgeâs Healthcare NHS Trust
London, UK

Carolyn Hemsley
Consultant in Infectious Diseases and Microbiology
Department of Infection
Guyâs & St Thomasâ NHS Foundation Trust
London, UK

Robert Hill
Unit Head
Antibiotic Resistance and Evaluation Unit
Public Health England Centre for Infections
London, UK

Matthew Laundy
Consultant Medical Microbiologist
St Georgeâs Healthcare NHS Trust
London, UK

Martin Llewelyn
Reader in Infectious Diseases and Therapeutics
Consultant in Infectious Diseases
Brighton and Sussex University Hospitals NHS Trust
Brighton, UK

Michael Loebinger PhD MRCP
Respiratory Consultant
Royal Brompton Hospital
Honorary Senior Lecturer
Imperial College London
London, UK

Derek Macallan
Professor of Infectious Diseases and Medicine and
Joint Head of The Infection And Immunity
Research Centre
St Georgeâs Healthcare NHS Trust
London, UK

David Moore
Reader Infectious Diseases and Tropical Medicine
London School of Hygiene and Tropical Medicine, UK
Elinor Moore
Consultant Physician in Infectious Diseases
Cambridge University Hospital NHS Foundation Trust
Cambridge, UK

William Newsholme
Consultant Physician
Department of Infection
St Thomasâs Hospital
Kings College Hospitals NHS Foundation Trust,
London, UK

Sue OâConnell
Formerly Consultant Medical Microbiologist and
Head of the HPAâs Lyme Borreliosis Unit
University Hospitals Southampton
NHS Foundation Trust
Southampton, UK

Chris Parry
Senior Clinical Consultant
Mahidol Oxford Tropical Medicine Research Unit
Angkor Hospital for Children
Siem Reap, Cambodia

Silke Schelenz
Clinical Senior Lecturer and
Consultant Microbiologist Norfolk and
Norwich University Hospitals
Microbiology Department
Norwich, UK

Sorrush Soleimanian
Consultant Medical Microbiologist
North Middlesex University Hospital NHS Trust
London, UK

Claire P. Thomas
Consultant, Clinical Microbiology
Honorary Senior Lecturer, Infectious Diseases
Department of Infection
Imperial College Healthcare Trust
London, Uk

Contributors

Daniel Bradshaw
Specialty Registrar in HIV and Genitourinary Medicine
Chelsea and Westminster Hospital NHS Foundation Trust, London, UK

Gayatri Chakrabarty
Specialty Registrar Gastroenterolog
St Georgeâs Healthcare NHS Trust
London, UK

Naghum Dawood
Specialty Registrar in Infectious Diseases and Medical Microbiology
Royal Free Hospital NHS Foundation Trust
London, UK

Rishi Dhillon
Consultant Microbiologist
University Hospital of Wales
Cardiff, UK

Tomas Doyle
Wellcome Trust Clinical Research Training Fellow
King's College London, UK

Ellen Dwyer
Specialty Registrar in HIV and Genitourinary medicine
St Georgeâs Healthcare NHS Trust
London, UK

Nicholas Easom
Academic Clinical Fellow Infectious Diseases and General Medicine
University College London Hospital
London, UK

Marcus Eder
Specialty Registrar in Infectious Diseases and Microbiology
Charing Cross Hospital
Imperial College Healthcare NHS Trust
London, UK

Kate El Bouzidi
Specialty Registrar in Infectious Diseases
and Medical Microbiology
St Georgeâs Healthcare NHS Trust
London, UK

Jayne Ellis
Academic Foundation year 2 Doctor
St Georgeâs Healthcare NHS Trust
London, UK

Nicholas Feasey
Senior Clinical Lecturer
Liverpool School of Tropical Medicine
University of Liverpool, UK

Caoimhe Nic Fhogartaigh
Specialty Registrar in Infectious Diseases
and Medical Microbiology
Hospital for Tropical Diseases at University College London Hospital
London, UK

James Hatcher
Specialty Registrar in Infectious Diseases and
Medical Microbiology
Hammersmith Hospital
Imperial College Healthcare NHS Trust
London, UK

Aseel Hegazi
Specialty Registrar in HIV and
Genitourinary Medicine
St Georgeâs Healthcare NHS Trust
London, UK

Angela Houston
Specialty Registrar in Infectious Diseases and
Microbiology at St Georgeâs Hospital NHS Trust
London, UK

Julia Howard
Specialty Registrar in Medical Microbiology
Royal Free London NHS Foundation Trust
London, UK

Jasmin Islam
Specialist Registrar in Infectious Diseases
and Medical Microbiology
Brighton and Sussex University Hospitals
NHS Trust
Brighton, UK

Jonathan Lambourne
Specialty Registrar in Infectious Diseases and
Microbiology
Rare and Imported Pathogens Laboratory
PHE Microbiology Services Porton
Porton Down, UK

Angela Loyse
Academic Clinical Lecturer
St Georgeâs Healthcare NHS Trust
London, UK

Mariyam Mirfenderesky
Specialty Registrar in Infectious Diseases and
Microbiology
St Georgeâs Healthcare NHS Trust
London, UK

Luke Moore
Specialty Registrar
Infectious Diseases and Medical Microbiology
Imperial College Healthcare NHS Trust
NIHR BRC Clinical Fellow
Division of Infectious Diseases and Immunity
Imperial College London, UK

Sally OâConnor
Specialty Registrar in Respiratory Medicine
St. Georgeâs Healthcare NHS Trust
London, UK

James Price
Specialty Registrar in Infectious Diseases and Medical
Microbiology
Brighton and Sussex University Hospitals NHS Trust
Brighton, UK

Michael Rayment
Specialty Registrar in HIV and Genitourinary Medicine
Chelsea and Westminster Hospital NHS
Foundation Trust
London, UK

Catherine Roberts
Specialty Registrar Infectious Diseases and Microbiology
Department of Medicine
Imperial College London, UK

Georgina Russell
Specialty Registrar in Respiratory Medicine
St. Georgeâs Healthcare NHS Trust
London, UK

Victoria Singh-Curry
Specialty Registrar in Neurology
Charing Cross Hospital
Imperial College NHS Foundation Trust
London, UK

Neill Storrar
Specialty Registrar Haematology
The Royal Infirmary of Edinburgh
Scotland, UK

Sathyavani Subbarao
Specialty Registrar in Infectious Diseases and Medicine
North Middlesex University Hospital NHS Trust, UK

Emily Wise
Specialty Registrar in Infectious Diseases
Royal Free London NHS Foundation Trust
London, UK