Central Regulation of Autonomic Functions

Second Edition

Edited by Ida J. Llewellyn-Smith and Anthony J. M. Verberne

The follow-up to the classic first edition published 20 years ago
One of the only books explaining the whole story of how the brain controls basic bodily functions
Edited by two well-known experts and researchers in the field

Central Regulation of Autonomic Functions

Second Edition

Edited by Ida J. Llewellyn-Smith and Anthony J. M. Verberne

Description

Central autonomic circuits in the brain and spinal cord are essential to vertebrate life: they control all basic bodily functions, including blood pressure, body temperature regulation, digestion, and reproduction.

Edited by two experts in the field, Ida Llewellyn-Smith and Anthony Verberne, and extensively illustrated, the second edition of Central Regulation of Autonomic Functions presents the extraordinary advances that have been made over the last 20 years in the understanding of how the central nervous system controls autonomic functions.

Written in a clear and readable manner by an international collection of neuroscientists and physiologists, and nine chapters describe central autonomic circuits from the cerebral cortex to the periphery. Eight more chapters address specific bodily functions and their control by central autonomic circuits. Two additional chapters discuss cardio-respiratory integration and regulation of autonomic function by visceral and somatic afferents. All of the chapters are up-to-date and cover topics such as the central autonomic regulation of airways, gastrointestinal function, energy homeostasis, body temperature, and sexual function, reflecting the latest research.

One of the only texts to provide the whole story of how the brain controls basic bodily functions that are critical for life, Central Regulation of Autonomic Functions will be essential reading for graduate students and researchers in neuroscience, anatomy, pharmacology and physiology as well as a valuable reference work for established workers in the field.

Central Regulation of Autonomic Functions

Second Edition

Edited by Ida J. Llewellyn-Smith and Anthony J. M. Verberne

Preface
Ida J. Llewellyn-Smith & Anthony J.M. Verberne

Chapter 1.
Central Autonomic Pathways
J. Patrick Card & Alan F. Sved

Chapter 2.
The Nucleus of the Solitary Tract: Processing Information from Viscerosensory Afferents
Michael C. Andresen & Julian F. R. Paton

Chapter 3
The Hypothalamus and Autonomic Regulation: An Overview
Roger A. L. Dampney

Chapter 4
Autonomic and Neuroendocrine Roles of the Paraventricular Nucleus
Javier E. Stern

Chapter 5
The Ventrolateral Medulla and Sympathetic Regulation of Arterial Pressure
Ann M. Schreihofer & Alan F. Sved.

Chapter 6
Sympathetic Preganglionic Neurons
Ida J. Llewellyn-Smith

Chapter 7
Parasympathetic Preganglionic Neurons
David Jordan

Chapter 8
Spinal Interneurons in the Control of Autonomic Function
Susan A. Deuchars

Chapter 9
Regulation of Autonomic Function by Visceral and Somatic Afferents
John C. Longhurst

Chapter 10
Cardiorespiratory Integration
Patrice G. Guyenet

Chapter 11
Modulation of Autonomic Function by the Cerebral Cortex
Anthony J. M. Verberne

Chapter 12
Central Circulatory Control: Psychological Stress and the Defense Reaction
Pascal L. Carrive

Chapter 13
Central Autonomic Regulation of the Airways
Brendan J. Canning

Chapter 14
Central Control of Gastrointestinal Function
Pamela J. Hornby & Paul R. Wade

Chapter 15
Central Autonomic Control of the Pancreas
R. Alberto Travagli & Kirsteen N. Browning

Chapter 16
Circumventricular Organs: Critical Autonomic Control Centers at the Blood Brain Interface
Alistair V. Ferguson

Chapter 17
Central Autonomic Control of Energy Homeostasis
Barry E. Levin & Alison M. Strack

Chapter 18
Central Nervous System Regulation of Body Temperature
Shaun F. Morrison & William W. Blessing

Chapter 19
Autonomic Regulation of the Urinary Bladder and Urethra
William C. de Groat

Chapter 20
Autonomic Regulation of Sexual Function
Lesley Marson

Central Regulation of Autonomic Functions

Second Edition

Edited by Ida J. Llewellyn-Smith and Anthony J. M. Verberne

Author Information

Ida J. Llewellyn-Smith, PhD, is Associate Professor in Medicine at Flinders University in Adelaide, Australia. She received her BA at Bryn Mawr College, and her PhD at the University of Sydney. She is best known for analyzing central nerve pathways that regulate the cardiovascular system using sophisticated light and electron microscopic techniques, many of which she developed herself. She is also Councilor of the American Physiology Society.

Anthony J. M. Verberne, PhD, is a Associate Professor in the University of Melbourne's Department of Medicine at Austin Health, Melbourne, Australia. He received his PhD from the University of Melbourne and in 2005 was awarded a Doctor of Science. He has served on the editorial boards of the American Journal of Physiology, the British Journal of Pharmacology and Brain Research Bulletin. His research has examined supramedullary circulatory control mechanisms, central cardiovascular reflex pathways as well as central control of pancreatic secretion and glucose homeostasis.

Contributors:

Michael C. Andresen, Ph.D. , Department of Physiology and Pharmacology, Oegon Health & Science University

W.W. Blessing, M.D., Ph.D., Department of Medicine, Flinders Medical Centre, Adelaide, Australia

Kirsteen N. Browning, Department of Neural and Behavioral Sciences, Pennsylvania State University College
of Medicine

Brendan J. Canning, Ph.D., The Johns Hopkins Asthma and Allergy Center

J. Patrick Card, Ph.D., Department of Neuroscience, University of Pittsburgh

Pascal L. Carrive, Ph.D., Department of Anatomy, School of Medical Sciences, University of New South Wales

Roger A. L. Dampney, Ph.D, D.Sc., Department of Physiology, University of Sydney

William C. de Groat, Ph.D., Department of Pharmacology and Chemical Biology, University of Pittsburgh

Susan A. Deuchars, Ph.D., Institute of Membrane and Systems Biology, University of Leeds

Alastair V. Ferguson, Ph.D. , Department of Physiology, Queens University, Ontario, Canada

Patrice G. Guyenet, Ph.D., Department of Pharmacology, University of Virginia

Pamela J. Hornby, Ph.D., Johnson & Johnson Biotechnology Center of Excellence, Pennsylvania

David Jordan, Ph.D., D.Sc., Department of Physiology, Royal Free & University College Medical School, UK

Barry E. Levin, M.D., Veterans Affairs Medical Center, Neurological Services, NJ

John C. Longhurst, Ph.D., Department of Medicine, University of California-Irvine

Lesley Marson, Ph.D., Division of Urology, University of North Carolina

Shaun F. Morrison, Ph.D., Oregon National Primate Research Center, Oregon Health and Science University

Julian F. R. Paton, Ph.D., Department of Physiology & Pharmacology, University of Bristol

Ann M. Schreihofer, Ph.D., Department of Integrative Physiology, University of North Texas

Javier E. Stern, M.D., Ph.D., Department of Physiology, Medical College of Georgia

Alison M. Strack, Department of Pharmacology, Merck Research Laboratories, NJ

Alan F. Sved, Ph.D., Department of Neuroscience, University of Pittsburgh

R. Alberto Travgali, Department of Neural and Behavioral Sciences, Pennsylvania State University College
of Medicine

Paul R. Wade, Department of Biosciences, GI Pharmacology, PA

Central Regulation of Autonomic Functions

Second Edition

Edited by Ida J. Llewellyn-Smith and Anthony J. M. Verberne

Reviews and Awards

"The editors have assembled another superb group of autonomic neuroscientists akin to those who contributed to the first edition that was published 20 years ago. The text is written from the perspective of the contributing basic scientist in each of the fields covered. Indeed, while the text limits itself short of a full exploration of central autonomic control, a great deal is covered...For the topics that are covered, the text would be a very fine addition to the library of the basic autonomic neuroscientist. The autonomic clinician would find the lovely basic scientific reviews of centrally regulated autonomic function a complement to other texts that cover pathophysiologic." -- William T. Talman, MD, Professor of Neurology and Neuroscience, Vice Chair for Basic Research in Neurology, Director-Laboratory of Neurobiology, University of Iowa, Carver College of Medicine, Chief Neurology Service, Department of Veterans Affairs Medical Center, President - FASEB

"This is a timely publication with outstanding chapters by leading international scientists in the field. It is admirably comprehensive and will serve the neuroscience community for years to come. The figures are exceptionally good and enhance the high quality of the book. My congratulations to the Co-Editors and the authors of chapters for putting together such a valuable publication." -- Geoffrey Burnstock PhD DSc FAA FRCS(Hon) FRCP(Hon) FMedSci FRS, Autonomic Neuroscience Centre, University College Medical School, University College London, UK

"This book... brings us up to date after two decades of intensive studies that extend down to the cellular and molecular level, supplementing rather than supplanting the 1990 volume of the same title edited by Loewy and Spyer. Since then, the development of novel techniques has yielded a wealth of detail about anatomical, physiological and neurochemical interactions in the complex networks that project directly or indirectly to diverse autonomic outflows. However, as the impressive array of skilled researchers who are the authors of this volume make clear, many questions about the mechanisms regulating and integrating these pathways in the adult organism remain to be addressed, probably by the next generation of autonomic neuroscientists. Everyone interested in autonomic function needs to read this valuable reference." -- Elspeth McLachlan, DSc, FAA, Emeritus Professor, Autonomic Physiology Unit, School of Life Sciences, University of Glasgow, Glasgow G12 8QQ UK

"This is a good and necessary update of the first edition. It is an excellent resource for most medical school libraries with strong neuroscience departments and active research." -- Doody's

"Llewellyn-Smith and Verberne have organized a solid update to the original monograph with outstanding authors and objective treatment of major issues in the field. The references alone make this a valuable publication and it represents an excellent, single text students can use in their academic preparation." -- The Physiologist