https://global.oup.com/academic/covers/pop-up/9780199985357

Bipolar Disorder in Youth

Presentation, Treatment and Neurobiology

Edited by Stephen M. Strakowski, Melissa P. DelBello, and Caleb M. Adler

Authored by international leaders in early course illness progression and bipolar disorder
The most comprehensive work available on bipolar disorder in the youth population
Includes both a scientific review and practical clinical applications

Bipolar Disorder in Youth

Presentation, Treatment and Neurobiology

Edited by Stephen M. Strakowski, Melissa P. DelBello, and Caleb M. Adler

Description

Bipolar disorders affect up to 3% of the world's population and are the 6th leading cause of disability worldwide. The estimated annual costs of bipolar disorder approach $50 billion in the United States, and the associated societal and personal suffering is immeasurable. Bipolar disorder is a lifelong illness that typically begins in mid-adolescence, thereby disrupting healthy developmental processes. It is also a progressive illness, making early intervention even more critical. As the disorder presents differently in youth as it does in adults, considerable controversy exists around the diagnosis in young people.

The neurobiological factors leading to the onset of bipolar disorder reflect abnormalities in adolescent brain development. Bipolar disorder is strongly heritable and therefore, these developmental abnormalities likely represent the culmination of processes that precede the expression of symptoms. Current studies of children who are at risk for bipolar disorder are identifying these processes. Again, controversy exists about how to move these neuroscience gains forward to help affected individuals and, particularly to manage children at risk to delay or prevent the onset or progression of bipolar disorder.

With these considerations in mind, Bipolar Disorder in Youth provides a timely, focused review of the diagnosis, treatment, and neurobiology of bipolar disorder in youth. It addresses current controversies and resolves those in which evidence is available. The book is organized into three sections based on these topics to provide comprehensive discussions to aid clinicians managing these individuals in their practices, as well as scientists trying to advance the field. The three editors are widely recognized experts in bipolar disorder, and the authors of each chapter represent international experts in the respective topics. Consequently, this book is the most comprehensive volume available discussing this important population and is a 'must' for the libraries of clinicians and scientists working with bipolar children and adolescents.

Bipolar Disorder in Youth

Presentation, Treatment and Neurobiology

Edited by Stephen M. Strakowski, Melissa P. DelBello, and Caleb M. Adler

Prologue: Introduction to bipolar disorder in youth
Section 1: Phenomenology and Diagnosis
Chapter 1: Progression of Bipolar Disorder in Youth: Defining the early clinical stages in the development of bipolar disorder
Anne Duffy
Chapter 2: Presentation of mania/bipolar I in youth: comparison with adults
Gabrielle A. Carlson
Caroly Pataki
Chapter 3: Differential Diagnosis of Bipolar Disorder in Children and Youth
Kenneth E. Towbin
Ellen Leibenluft
Chapter 4: Comorbid conditions in youth with and at-risk for bipolar disorder
Gagan Joshi
Timothy Wilens
Chapter 5: Heritability of bipolar disorder
Katie Maho
Katherine E. Burdick
Anil K. Malhotra
Chapter 6: Non-heritable risk factors for bipolar disorders
Robert K. McNamara
Jeffrey R. Strawn
Section 2: Treatment of bipolar disorder in youth
Chapter 7: Ethical consideration for treating at-risk populations
Aswin Ratheesh
Michael Berk
Patrick D. McGorry
Chapter 8: Medical treatment strategies for young people with bipolar disorder
Sarah M. Lytle
Sonal K. Moratschek
Robert L. Findling
Chapter 9: Psychotherapeutic strategies for treating youth with or at risk for bipolar disorder
David J. Miklowitz
Chapter 10: Complementary and Alternative Medicine in Child and Adolescent Bipolar Disorder
Barbara L. Gracious
Sathyan Gurumurthy
Alexandra Cottle
Taylor McCabe
Section 3: Neurobiology of bipolar disorder
Chapter 11: Neurobiology of Developing Bipolar Disorder
Jillian M. Russo
Sonja M.C. de Zwarte
Hilary P. Blumberg
Chapter 12: Neurobiology of bipolar disorder in youth
Mani N. Pavaluri
Chapter 13: Neurocognitive Models of Evolving Bipolar Disorder in Youth
Alessandra M. Passarotti
Chapter 14: The neural effects of intervention in pediatric bipolar disorder
Manpreet K. Singh
Kiki D. Chang
Chapter 15: Integration and Future Direction: Toward improving outcomes for youth with bipolar disorder
Luis Rodrigo Patino Duran
Peirce Johnston
Caleb M. Adler
Melissa P. DelBello
Stephen M. Strakowski

Bipolar Disorder in Youth

Presentation, Treatment and Neurobiology

Edited by Stephen M. Strakowski, Melissa P. DelBello, and Caleb M. Adler

Author Information

Edited by Stephen M. Strakowski, Senior Associate Dean for Research and The Dr. Stanley and Mickey Kaplan Professor and Chairman of Psychiatry, University of Cincinnati College of Medicine, USA, Melissa P. DelBello, Professor of Psychiatry, Pediatrics and Psychology, Department of Psychiatry, University of Cincinnati College of Medicine, USA, and Caleb M. Adler, Associate Professor in Clinical Psychiatry and Neuroscience; and Co-Director Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, USA

Drs. Strakowski, DelBello and Adler comprise one of the most widely recognized research groups studying the neurophysiology, outcome and treatment of bipolar disorder and related conditions. Their work concentrates on early course illness progression and has defined many of the brain system dysfunctions that underlie bipolar disorder as well as treatment interventions in youth.

Contributors:

Caleb M. Adler, MD
Department of Psychiatry & Behavioral Neuroscience
University of Cincinnati
Cincinnati, Ohio, USA

Michael Berk, MD
NHMRC Senior Principal Research Fellow
Alfred Deakin Professor of Psychiatry, School of Medicine, Deakin University.
Professorial Research Fellow, The Florey Institute of Neuroscience and Mental Health, Orygen Research Centre and the Department of Psychiatry, University of Melbourne
Melbourne, Australia

Hilary P. Blumberg, M.D.
Department of Psychiatry
Yale School of Medicine
New Haven, Connecticut, USA

Katherine E. Burdick, PhD
Icahn School of Medicine at Mount Sinai
Departments of Psychiatry and Neuroscience
New York, New York, USA

Gabrielle A. Carlson, MD
Professor of Psychiatry and Pediatrics
Stony Brook University School of Medicine
Putnam Hall-South Campus
Stony Brook, New York, USA

Kiki D. Chang, MD
Professor of Psychiatry and Behavioral Sciences
Stanford University Medical Center
Stanford, California, USA

Alexandra Cottle
Research Assistant, Center for Innovation in Pediatric Practice
The Research Institute at Nationwide Children's Hospital
Columbus, Ohio, USA

Anne Duffy, MD
Department of Psychiatry, Faculty of Medicine,
Calgary University
Calgary, Alberta, Canada

Melissa P. DelBello, MD
Department of Psychiatry and Behavioral Neuroscience
University of Cincinnati Medical Center
Cincinnati, Ohio, USA

Robert L. Findling, MD, MBA
Stulman Professor and Director of Child & Adolescent Psychiatry
Johns Hopkins University
Vice President of Psychiatry Services and Research
Kennedy Krieger Institute
Baltimore, Maryland, USA

Barbara L. Gracious, MD
Jeffrey Research Fellow, Center for Innovation in Pediatric Practice
The Research Institute at Nationwide Children's Hospital
Associate Professor of Clinical Psychiatry and Nutrition
The Ohio State University
Columbus, Ohio, USA

Sathyan Gurumurthy, MD
Department of Psychiatry
Ohio State University Medical Center
Columbus, Ohio, USA

Peirce Johnston, MD
University of Cincinnati Health Psychiatry
Cincinnati, Ohio, USA

Gagan Joshi, M.D
Assistant Professor of Psychiatry
Harvard Medical School
Boston, Massachusetts, USA

Ellen Leibenluft, MD
Chief, Section on Bipolar Spectrum Disorders Co-Chief, Emotion and Development Branch Division of Intramural Research Programs National Institute of Mental Health
Bethesda, Maryland, USA

Sarah M. Lytle, MD, MS
Fellow, Academic Chief
Division of Child and Adolescent Psychiatry
University Hospitals Case Medical Center
Cleveland, Ohio, USA

Katie Mahon, PhD
Icahn School of Medicine at Mount Sinai
Departments of Psychiatry and Neuroscience
New York, New York, USA

Anil K. Malhotra, MD
The Zucker Hillside Hospital,
North Shore-Long Island Jewish Health System,
Department of Psychiatry Research, Glen Oaks, NY;
The Feinstein Institute for Medical Research, Manhasset, NY;
Hofstra University School of Medicine, Department of Psychiatry

Taylor M. McCabe, SN/STNA
Ohio Northern University
Ada, Ohio, USA

Patrick D. McGorry, MD
Professor of Youth Mental Health
University of Melbourne
Melbourne, Australia

Robert K. McNamara, PhD
Department of Psychiatry and Behavioral Neuroscience
University of Cincinnati College of Medicine
Cincinnati, Ohio, USA

David J. Miklowitz, PhD
Director, Child and Adolescent Mood Disorders Program
Director, Integrative Study Center for Mood Disorders
UCLA Semel Institute for Neuroscience and Human Behavior
Division of Child and Adolescent Psychiatry
David Geffen School of Medicine at UCLA
Los Angeles, California, USA

Sonal K. Moratschek, MD, MPH
Fellow, Clinical Chief
Division of Child and Adolescent Psychiatry
University Hospitals Case Medical Center
Cleveland, Ohio, USA

Alessandra M. Passarotti, PhD
Assistant Professor
Pediatric Brain Research and Intervention Center
Institute for Juvenile Research, Dept. of Psychiatry
University of Illinois at Chicago
Chicago, Illinois, USA

Caroly Pataki, MD
Clinical Professor of Psychiatry and Pediatrics
Keck School of Medicine of the University of Southern California
Santa Monica, California, USA

L. Rodrigo Patino Duran MD, MSc
Department of Psychiatry& Behavioral Neuroscience
Division of Bipolar Disorders Research
University of Cincinnati
Cincinnati, Ohio, USA

Mani N. Pavuluri, MD PhD
Berger-Colbeth Chair in Child Psychiatry
University of Illinois at Chicago
Chicago, Illinois, USA

Aswin Ratheesh, MD
Centre for Youth Mental Health,
University of Melbourne,
Orygen Youth Health Clinical Program,
Parkville, Victoria, Australia

Jillian M. Russo, PsyD
Mood Disorders Research Program
Department of Psychiatry
Yale School of Medicine
New Haven, Connecticut, USA

Manpreet K. Singh, MD, MS
Assistant Professor of Psychiatry and Behavioral Sciences
Akiko Yamazaki and Jerry Yang Faculty Scholar in Pediatric Translational Medicine
Stanford University School of Medicine
Stanford, California, USA

Stephen M. Strakowski, MD
Senior Vice President for Strategic Planning & Business Development, UC Health
The Dr. Stanley and Mickey Kaplan Professor and Chairman,
Department of Psychiatry & Behavioral Neuroscience
University of Cincinnati Neuroscience Institute
Cincinnati, Ohio, USA

Jeffrey R. Strawn, MD
Department of Psychiatry and Behavioral Neuroscience
University of Cincinnati College of Medicine
Cincinnati, Ohio, USA

Kenneth E. Towbin, MD
Chief, Clinical Child & Adolescent Psychiatry Emotion and Development Branch
National Institute of Mental Health
US Department of Health and Human Services
Bethesda, Maryland, USA

Timothy Wilens, MD
Director, Center for Addiction Medicine,
Senior Staff in Child Psychiatry,
Division of Child Psychiatry, Massachusetts General Hospital;
Associate Professor of Psychiatry,
Harvard Medical School
Boston, Massachusetts, USA

Sonja M.C. de Zwarte, MSc, Neurosciences
PhD Candidate, Department of Psychiatry
UMC Utrecht
Utrecht, Netherlands