Biochalcogen Chemistry

The Biological Chemistry of Sulfur, Selenium, and Tellurium

Edited by Craig A. Bayse and Julia L. Brumaghim

American Chemical Society

ACS Symposium Series

- A useful collection of reviews and research results, encompassing research in bioinorganic chemistry, organic synthesis, computational approaches, and biochemistry
- An inspiration for researchers wishing to enter the variety of fields

Biochalcogen Chemistry

The Biological Chemistry of Sulfur, Selenium, and Tellurium

Edited by Craig A. Bayse and Julia L. Brumaghim

American Chemical Society

Description

Biochalcogen Chemistry: The Biological Chemistry of Sulfur, Selenium, and Tellurium highlights the biological uses of heavy chalcogens as a key area of focus in bioinorganic chemistry and a unifying theme for research in a wide variety of disciplines. Recent achievements in these multidisciplinary efforts are presented that discuss the subtle, yet important roles of biochalcogens in living systems as sulfur- and selenium-containing metabolic intermediates and products (Chapters 1 and 10) and in their oxidation when coordinated to metals (Chapters 3 and 4). Chemical and instrumental tools for detecting sulfur and selenium species and their functionalities are also discussed (Chapters 2 and 6), as are new directions in biochalcogen applications to redox scavenging, both in terms of synthesis (Chapters 7 and 8) and mechanistic modeling (Chapter 9). Tellurium, with no natural biological function, is represented together with sulfur and selenium as a phasing agent in nucleic acid crystallography and for other biological studies (Chapter 5).

This book will serve as a useful collection of reviews and research results in this diverse field, encompassing research in bioinorganic chemistry, organic synthesis, computational approaches, and biochemistry, as an inspiration for researchers wishing to enter the variety of fields that encompass these multidisciplinary research efforts, and as a useful resource for undergraduate or graduate courses focusing on main group and transition element biochemistry. A wide audience will find this book a helpful resource for this rapidly expanding field.

Biochalcogen Chemistry

The Biological Chemistry of Sulfur, Selenium, and Tellurium

Edited by Craig A. Bayse and Julia L. Brumaghim

American Chemical Society

ACS Symposium Series

Contents
Preface
1. Smelling Sulfur: Discovery of a Sulfur-Sensing Olfactory Receptor that
Requires Copper
2. Chemical Tools for Studying Biological Hydrogen Sulfide
3. Thione- and Selone-Containing Compounds, Their Late First Row
Transition Metal Coordination Chemistry, and Their Biological Potential
4. Sulfur Oxygenation Enhances Ligand Exchange in Nitrile-Hydratase-
Inspired Ruthenium(II) Complexes
5. Biochemistry of Nucleic Acids Functionalized with Sulfur, Selenium, and
Tellurium: Roles of the Single-Atom Substitution
6. 77Se NMR Spectroscopy of Selenoproteins
7. Investigations of New Types of Glutathione Peroxidase Mimetics
8. Emulating Antioxidative Functions of Glutathione Peroxidase Using
Selenopeptides
9. Modeling of Mechanisms of Selenium Bioactivity Using Density Functional
Theory
10. Selenotrisulfide as a Metabolic Intermediate in Biological Systems
Editors' Biographies
Indexes
Author Index
Subject Index

Biochalcogen Chemistry

The Biological Chemistry of Sulfur, Selenium, and Tellurium

Edited by Craig A. Bayse and Julia L. Brumaghim

American Chemical Society

ACS Symposium Series

Author Information

Craig A. Bayse received his B.S. in chemistry from Roanoke College in 1994 and his Ph.D. at Texas A&M University in 1998, working with Michael B. Hall on theoretical studies of the structure and bonding of transition metal hydride complexes. As a graduate student, he attended the European Summer School in Quantum Chemistry in Sweden and the Sostrup Summer School on Quantum Chemistry and Molecular Properties in Denmark. He took a brief hiatus from computational chemistry during a Kodak-funded postdoctoral appointment at Cornell University with Barry K. Carpenter, synthesizing novel azoalkanes. More recently, he added molecular dynamics simulations of proteins to his repertoire through a sabbatical appointment at the University of Florida with Kennie M. Merz. His research uses an amalgam of these computational and experimental approaches to explore the bonding and reactivity of inorganic systems. His contributions include mechanistic studies of bioactive selenium and sulfur compounds; theoretical studies of the active sites of molybdenum and tungsten enzymes; determination of the electronic structure of luminescent coinage metal materials; and bonding models of ?-stacking interactions. He is currently Professor of Chemistry and Biochemistry at Old Dominion University.

Julia L. Brumaghim received her Ph.D. degree from the University of Illinois at Urbana-Champaign and completed postdoctoral research at the University of California at Berkeley in both Bioinorganic Chemistry and Cellular and Molecular Biology. She is currently an Associate Professor in the Department of Chemistry at Clemson University in Clemson, SC. Recent work primarily focuses on metalmediated oxidative DNA damage and the mechanisms by which sulfur, selenium, and polyphenolic antioxidant compounds prevent this damage. In addition, she is investigating the ability of nanomaterials to generate reactive oxygen species and promote oxidative damage. She has published over 40 papers, has presented her research at over 80 scientific conferences and universities, and has been a recipient of the ACS PROGRESS/Dreyfus Lectureship Award from the American Chemical Society and Camille and Henry Dreyfus Foundation, a CAREER award from the National Science Foundation, and the 2008 Award for the Best Paper from A Young Investigator, Journal of Inorganic Biochemistry and Elsevier Publishers.

Contributors:

Thomas G. Back
T. Spencer Bailey
Craig A. Bayse
Eric Block
Julia L. Brumaghim
Julianne Caton-Williams
Takeshi Fuchigami
Katsuyoshi Fujimoto
Craig A. Grapperhaus
Matthew D. Hammers
Mamoru Haratake
Zhen Huang
Michio Iwoaka
Manindar Kaur
Hongoh Masafumi
Mark S. Mashuta
César A. Masitas
Leticia A. Montoya
Morio Nakayama
Michael D. Pluth
Abdur Rob
Sharon Rozovsky
Bradley S. Stadelman
Sakura Yoshida
Hanyi Zhuang