Asthma

Comorbidities, Coexisting Conditions, and Differential Diagnosis

Edited by Richard F. Lockey,MD , Dennis K. Ledford,MD , and WAO

The first book to cover the topic of asthma and comorbidities and coexisting conditions for differential diagnosis
Guides clinicians in achieving optimal treatment outcomes by elucidating factors which may affect asthma or asthma symptoms
Includes the hot topic of the effects of climate change and biodiversity on asthma and its comorbidities and coexisting conditions
Written with a global perspective by an internationally esteemed group of authors

Asthma

Comorbidities, Coexisting Conditions, and Differential Diagnosis

Edited by Richard F. Lockey,MD , Dennis K. Ledford,MD , and WAO

Description

Asthma sufferers number approximately 200 million worldwide, with 15-20 million of those in the United States. Multiple comorbid conditions occur with asthma, including rhinitis, rhinosinusitis, gastroesophageal reflux disease, sleep apnea, vocal cord dysfunction syndrome, obesity, and chronic obstructive pulmonary disease (COPD). Without identifying and caring for comorbid conditions, asthma cannot be treated appropriately. Comorbidity of allergic diseases emphasizes that we must understand more about why different organs in individuals express allergy and others do not. The increase in multiple allergies occurring in a single patient makes the global burden even more complex, and an integrated approach to diagnosis and new treatment strategies and preventative approaches are required. Asthma: Comorbidities, Coexisting Conditions, and Differential Diagnosis is the first volume to provide a centralized, a comprehensive clinical reference on the diagnosis and management of the comorbid conditions that affect asthma. Because comorbid conditions of asthma have not yet been included in international and national management guidelines, this volume will help fill a gap in current clinical knowledge, aiding physicians in delivering optimal patient care. Written and published in conjunction with the World Allergy Organization (WAO), this book consists of the latest research and reviews of current theory and practice, the most effective advances in the diagnosis and management of asthma and its co-morbidities, and insights into the fundamentals of asthma and its co-morbidities. It presents scientifically-based medicine for each comorbid condition as it relates to asthma.

Asthma

Comorbidities, Coexisting Conditions, and Differential Diagnosis

Edited by Richard F. Lockey,MD , Dennis K. Ledford,MD , and WAO

Section 1 - Immunologic
1. Hypersensitivity Pneumonitis
2. Anti-neutrophil Cytoplasmic Antibody (ANCA) Positive Vasculitis
3. Allergic Bronchopulmonary Aspergillosis (ABPA)
4.Immunodeficiency: Innate, Primary and Secondary
Section 2 - Pulmonary
5. Sleep Apnea - Comorbid and Coexisting - in Children and the Upper Airway
6. Asthma and Obstructive Sleep Apnea
7. COPD and Irreversible Airflow Obstruction
8. Bronchiectasis
9. Bronchiolitis
10. Genetic Disorders and Asthma
11. Other Pulmonary Abnormalities
12. Pneumonia - Comorbid and Co-existing
13. Cough
14. Occupational Asthma - Comorbid and Differential Diagnosis
Section 3 - Cardiac & Cardiovascular
15. Adult Cardiac Conditions
16. Pediatric Cardiac Conditions - Coexisting and Differential Diagnosis
17. Pulmonary Hypertension
Section 4 - Upper/Extrathoracic Airway
18. Allergic Rhinitis
19. Nonallergic Rhinopathies and Lower Airway Syndromes
20. Infectious Comorbidities of Asthma in the Upper Airway
21. Nasal Polyps - Comorbid
22. Vocal Cord Dysfunction and Paradoxical Vocal Fold Motion Disorder
Section 5 - Gastrointestinal
23. Gastroesophageal Reflux
Section 6 - Metabolic
24. Obesity and Asthma
25. Endocrine Disorders - Comorbid and Coexisting
26. Osteopenia and Osteoporosis: Comorbidities of Asthma
27. Pregnancy - Comorbid and Coexisting
Section 7 - Psychological Issues
28. Psychological Factors - Comorbid and Coexisting
29. Asthma, Substance Abuse, and Tobacco Use
Section 8 - Exercise
30. Exercise-induced Bronchoconstriction and Asthma
Section 9 - Environmental & Population Effects
31. Environmental Risk Factors in Asthma
Section 10 - Age
32. Age and Asthma
Section 11 - Food
33. Atopic Dermatitis, Food Allergy and Anaphylaxis - Comorbid and Coexisting

Asthma

Comorbidities, Coexisting Conditions, and Differential Diagnosis

Edited by Richard F. Lockey,MD , Dennis K. Ledford,MD , and WAO

Author Information

Edited by Richard F. Lockey, MD, Professor of Medicine, Pediatrics and Public Health, Director, Division of Allergy and Immunology, Joy McCann Culverhouse Chair in Allergy and Immunology, University Distinguished Health Professor, Asthma, Allergy & Immunology Clinical Research Unit, University of South Florida College of Medicine, James A. Halley Veterans Hospital, Tampa, Florida, USA, Dennis K. Ledford, MD, Professor of Medicine and Pediatrics, Asthma Allergy & Immunology Clinical Research Unit, Division of Allergy and Immunology, University of South Florida College of Medicine, James A. Haley Veterans Administration Hospital, Tampa, Florida, USA, and WAO, World Allergy Organization, Milwaukee, Wisconsin, USA

RFL: Professor of Medicine, Pediatrics and Public Health, Director, Division of Allergy and Immunology, Joy McCann Culverhouse Chair in Allergy and Immunology, University Distinguished Health Professor, Asthma, Allergy, and Immunology Clinical Research Unit, University of South Florida College of Medicine, Tampa, Florida. DKL: Professor of Medicine and Pediatrics, Division of Allergy and Immunology, Asthma, Allergy, and Immunology Clinical Research Unit, University of South Florida College of Medicine, Tampa, Florida. President-Elect of the American Academy of Allergy, Asthma, and Immunology; WAO:a global resource and advocate in the field of allergy, advancing excellence in clinical care through education, research and training as a worldwide alliance of allergy and clinical immunology societies, Milwaukee, WI.

Contributors:

Ignacio Ansotegui, MD
Head, Department of Allergy and Immunology
Hospital Quiron Bizkaia
Erandio, Spain

Andrea Apter, MD
Professor of Medicine
University of Pennsylvania School of Medicine
Penn Presbyterian Medical Center
Philadelphia, Pennsylvania

Ilaria Baiardini, PhD
Department of Allergy & Immunology
Institute of Immunophysiology
University of Russia
Moscow, Russia

Claus Bachert, MD, PhD
Chief of Clinic, ENT Department
University of Ghent
Gent, Belgium

Promila Banerjee, MD
Associate Professor of Medicine
Loyola University Medical Center
Department of Gastroenterology
Veterans Affairs Hospital
Hines, Illinois

James N. Baraniuk, MD
Associate Professor of Rheumatology, Immunology and Allergy
Georgetown University
Washington D.C.

David I. Bernstein, MD
Professor of Medicine and Environmental Health
University of Cincinnati College of Medicine
Cincinnati, Ohio

Louis I. Bezold, MD
Vice-Chair of Pediatrics
University of Kentucky College of Medicine
Lexington, Kentucky

Michael S. Blaiss, MD
Clinical Professor of Pediatrics and Medicine
University of Tennessee Health Sciences Center
Germantown, Tennessee

Matteo Bonini, MD, PhD
Department of Internal Medicine Lung Function Unit
Sapienza University of Rome
Institute of Translational Pharmacology
Rome, Italy

Sergio Bonini, MD
Department of Medicine
Second University of Naples
Institute of Translational Pharmacology
Naples, Italy

Louis-Philippe Boulet, MD
Laval University Heart and Lung Institute (IUCPQ)
Quebec, Canada

Emily P. Brigham, MD
Department of Pulmonary and Critical Care
Johns Hopkins University School of Medicine
Baltimore, Maryland

Fulvio Braido, MD
Allergy & Respiratory Diseases Clinic - DIMI
University of Genoa
IRCCS San Martino-IST University Hospital
Genova, Italy

Jean M. Brown, MD
Department of Allergy, Immunology & Rheumatology
University of South Florida College of Medicine
Tampa, Florida

Pasquale Caponnetto, PhD
Director of The Institute of Internal Medicine and Clinical Immunology
University of Catania
Center for the Prevention and Treatment of Tobacco Smoking
Policlinico-Vittorio Emanuele University Hospital
Catania, Italy

G. Walter Canonica, MD
Allergy & Respiratory Diseases
Department of Internal Medicine
Genoa University
Genoa, Italy

Roberto Castano, MD, PhD
Department of Epidemiology & Biostatistics and Occupational Health
McGill University
Hopital du Sacre-Coeur de Montreal
Montreal, Quebec, Canada

Mario Cazzola, MD
Department of System Medicine
University of Rome Tor Vergata
IRCCS San Raffaela Pisana Hospital
Rome, Italy

Juan C. Celedon, MD, DrPH
Neil K. Jerne Professor of Pediatrics
Professor of Medicine
Professor of Human Genetics
University of Pittsburgh School of Medicine
Children's Hospital of Pittsburgh of UPMC
Pittsburgh, Pennsylvania

Kelly J. Cowan, MD
Department of Pulmonology & Sleep Medicine
University of Wisconsin School of Medicine and Public Health
Madison, Wisconsin

Adnan Custovic, MD, PhD
Professor of Allergy
University Hospital of South Manchester
Manchester, United Kingdom

Ronald Dahl, MD
Professor
Aarhus University
Odense University Hospital
Denmark

Richard D. deShazo, MD
Billy S. Guyton Distinguished Professor
Professor of Medicine and Pediatrics
University of Mississippi Medical Center
Jackson, Mississippi

Alessandro Fiocchi, MD
Chief, Division of Allergy
Department of Pediatrics
Bambino Gesu Hosptial
Rome, Vatican City, Italy

Erik Forno, MD MPH
Assistant Professor of Pediatrics
University of Pittsburgh School of Medicine
Children's Hospital of Pittsburgh of UPMC
Pittsburgh, Pennsylvania

Roger W. Fox, MD
Professor of Medicine, Pediatrics and Public Health
University of South Florida College of Medicine
Tampa, Florida

Denyse Gautrin, PhD
Professor of Preventative and Social Medicine
University of Montreal
Hopital du Sacre-Coeur de Montreal
Montreal, Quebec, Canada

Mark C. Glaum, MD, PhD
Associate Professor of Medicine and Pediatrics
University of South Florida College of Medicine
Tampa, Florida

Alan Goldsobel, MD
Allergy and Asthma Associates of Northern California
Adjunct Associate Clinical Professor of Pediatrics
Stanford University School of Medicine
Clinical Professor of Medicine
University of California — San Francisco
San Francisco, California

Sandra Gonzalez-Diaz, MD, PhD
Head, Allergy & Clinical Immunology
Hospital Universitario and Medical School
Universidad Autonoma de Nuevo Leon
Monterrey, Mexico

Paul A. Greenberger, MD
Professor of Medicine-Allergy-Immunology
Northwestern University Feinberg School of Medicine
Chicago, Illinois

Theresa W. Guilbert, MD
Assistant Professor of Pediatric Pulmonology
University of Wisconsin School of Medicine and Public Health
Madison, Wisconsin

Tari Haahtela, MD, PhD
Professor of Medicine
Helsinki University Hospital
Skin and Allergy Hospital
Helsinki, Finland

Athanasios Kaditis, MD
Assistant Professor of Pediatrics and Pediatric Pulmonology
First Department of Pediatrics
Pediatric Pulmonology Unit, Sleep Disorders Laboratory
University of Athens School of Medicine
Aghia Sophia Children's Hospital
Athens, Greece

Omer Kalayci, MD
Professor of Medicine
Hacettepe University
Ankara, Turkey

Pramod Kelkar, MD
Founder, National Cough Clinic
Partner, Allergy and Asthma Care, PA
Maple Grove, Minnesota

James King, DO
Adjunct Clinical Associate Professor of Medicine
University of South Florida College of Medicine
Tampa, Florida

Marek Kowalski, MD
Department of Immunology, Rheumatology and Allergy
Medical University of Lodz
Lodz, Poland

Manon Labrecque, MD, MSc
Professor of Medicine
University of Montreal
Hopital du Sacre-Coeur de Montreal
Montreal, Quebec, Canada

Larry M. Ladi, M.D.
Department of Pulmonary Disease & Critical Care Medicine
Drexel University College of Medicine
Hahnemann University Hospital
Philadelphia, Pennsylvania

Andre Moreira, MD, PhD
Faculty of Medicine
University of Porto
Centro Hospitalar de Sao Joao
Porto, Portugal

Gregory Moullec, PhD
Department of Medicine
Hopital du Sacre-Coeur de Montreal
Montreal, Quebec, Canada

Robert M. Naclerio, MD
Professor of Surgery
The University of Chicago School of Medicine
University of Chicago Medical Center
Chicago, Illinois

Nizar Naji, MB, MRCPI
Department of Medicine
McMaster University
Firestone Institute for Respiratory Disease
St. Joseph's Hospital
Hamilton, Ontario, Canada

Jennifer A. Namazy, MD
Scripps Clinic Medical Group
San Diego, California

Paul M. O'Byrne, MB, FRCP(C), FRSC
Professor of Respirology
Chair, Department of Medicine
McMaster University
Firestone Institute for Respiratory Disease
St. Joseph's Hospital
Hamilton, Ontario, Canada

Nikolaos G. Papadopoulos, MD, PhD
Allergy Department
2nd Pediatric Clinic
University of Athens School of Medicine
Athens, Greece

Hae-Sim Park, MD
Department of Allergy and Clinical Immunology
Ajou University School of Medicine
Suwon, South Korea

Debendra Pattanaik, MD, FAAAAI, FACR
Assistant Professor of Medicine
University of Tennessee Health Science Center
Memphis, Tennessee

Ruby Pawankar, MD, PhD, FRCP, FAAAAI
Professor of Rhinology and Allergy
Nippon Medical School
Tokyo, Japan

Stephen P. Peters, MD, PhD, FAAAAI, FACP, FCCP, FCPP
Professor of Internal Medicine, Pediatrics and Translational Science
Associate Director, Center for Genomics and Personalized Medicine Research
Wake Forest School of Medicine
Winston-Salem, North Carolina

Riccardo Polosa, MD, PhD
Professor of Internal Medicine
University of Catania
Center for the Prevention and Treatment of Tobacco Smoking
Policlinico-Vittorio Emanuele University Hospital
Catania, Italy

Chelle Pope, MD
Department of Medicine
University of Mississippi Medical Center
Jackson, Mississippi

Sepiashvili Revaz, MD, PhD
Head of the Department of Allergy & Immunology
Director of the Institute of Immunophysiology
University of Russia
Moscow, Russia

Paola Rogliani, MD
Professor of System Medicine
University of Rome Tor Vergata
Rome, Italy

Lanny J. Rosenwasser, MD
Dee Lyons/Missouri Endowed Chair in Pediatric Immunology Research
Professor of Pediatrics, Allergy/Immunology Division
Children's Mercy Hospital
Professor of Pediatrics, Medicine, and Basic Science
University of Missouri-Kansas City, School of Medicine
Kansas City, Missouri

Hugh A. Sampson, MD
Dean of Translational Biomedical Sciences
Professor of Pediatrics, Allergy and Immunology
Mount Sinai School of Medicine
New York, New York

Mario Sanchez-Borges, MD
Clinical Immunology
Central University of Venezuela
Allergy/Immunology Service
La Trinidad Medical Center
Caracas, Venezuela

Michael Schatz, MD, MS
Department of Allergy
Kaiser Permanente Medical Center
San Diego, California

Edward Schulman, MD
Professor of Medicine
Department of Pulmonary Disease & Critical Care Medicine
Drexel University College of Medicine
Director, Allergy and Asthma Center
Hahnemann University Hospital
Philadelphia, Pennsylvania

Andrea Segreti, MD
Department of System Medicine
University of Rome Tor Vergata
Rome, Italy

Seung Youp Shin, MD
Department of Otolaryngology
Kyung Hee University School of Medicine
Seoul, South Korea

Scott Sicherer, MD
Professor of Pediatrics, Allergy and Immunology
Mt. Sinai School of Medicine
New York, New York
Mount Sinai School of Medicine
New York, New York

Kyriaki Sideri, MD
Allergy Department
University Hospital of South Manchester
Manchester, United Kingdom

Chrysanthi L. Skevaki, MD, PhD
Allergy Department
2nd Pediatric Clinic
Microbiology Department
University of Athens School of Medicine
Athens, Greece

Tatiana Slavyanskaya, MD, PhD
Department of Allergy & Immunology
Institute of Immunophysiology
University of Russia
Moscow, Russia

John W. Sleasman, MD
Chief of the Division of Pediatric Allergy, Immunology and Rheumatology
Robert A. Good Endowed Chair of Immunology
University of South Florida College of Medicine
Tampa, Florida

Kerri Akaya Smith, MD
Assistant Professor of Medicine
University of Pennsylvania
Philadelphia, Pennsylvania

Stephen J. Sontag, MD
Associate Professor of Medicine
Loyola University Medical Center
Department of Gastroenterology
Veterans Affairs Hospital
Hines, Illinois

Joshua Steinberg, MD
Assistant Professor of Allergy and Immunology
Medical College of Wisconsin
Children's Hospital of Wisconsin
Milwaukee, Wisconsin
Neetu Talreja, MD

Affiliate Assistant Professor of Medicine
Division of Allergy and Immunology
Department of Internal Medicine
University of South Florida College of Medicine
Tampa, Florida

Athanassios Tsakris, MD, PhD
Microbiology Department
University of Athens School of Medicine
Athens, Greece

Griet Vandeplas, MD
ENT Resident
Ghent University
Gent, Belgium

Julie Wang, MD
Associate Professor of Pediatrics, Allergy and Immunology
Mount Sinai School of Medicine
New York, New York

Aaron B. Waxman, MD, PhD
Associate Professor of Medicine
Harvard Medical School
Director, Pulmonary Vascular Disease Program
Brigham and Women's Hospital
Boston, Massachusetts

Robert A. Wise, MD
Professor of Medicine, Pulmonary and Critical Care
Johns Hopkins University School of Medicine
Johns Hopkins Asthma & Allergy Center
Baltimore, Maryland

Asthma

Comorbidities, Coexisting Conditions, and Differential Diagnosis

Edited by Richard F. Lockey,MD , Dennis K. Ledford,MD , and WAO

Reviews and Awards

"This book, which is written by a respected group of international authors, will provide a valuable reference for both primary and secondary care clinicians as well as allied health professionals and students who are looking for succinct, up to date information to help them holistically manage their asthma patients." - British Journal of Hospital Medicine

"This book represents an interesting advance to better understand the relationships between asthma and other chronic conditions... It will certainly stimulate discussions between senior physicians and scientists in the field of asthma." - European Respiratory Review