Preface
1:Cancer Drug Discovery and Development: New Paradigms for a New Millennium, E. A. Sausville, J. I. Johnson, C. M. Cragg, and S. Decker
2:Evolutionary Biosynthesis of Anticancer Drugs, George R. Pettit
3:Some Recent Developments in the Synthesis and SAR of Novel Taxanes, John F. Kadow, Thomas Altstadt, Shu-Hui Chen, Pierre Dextraze Karen Du, Craig Fairchild, Jerzy Golik, Steven Hansel, Kathy A. Johnston, Robert A. Kramer, David R. Langley, Frank Lee, Byron Long, Harold Mastalerz, Carl Ouellet, Robert Perrone, William C. Rose, Paul Scola, Gene Schultz, Andrew Staab, Quifen May Xue, Michael Walker, Jen-Mei Wei, Mark Wittman, J. J. Kim Wright, Mary Zoeckler, and Dolatrai M. Yvas
4:New Generation Taxoids and Hybrids of Microtube-Stabilizing Anticancer Agents, Iwao Ojima, Scott D. Kuduk, Subrata Chakravarty, Songnian Lin, Tao Wang, Xudong Geng, Michael L. Miller, Pierre-Yves Bounaud, Young Hoon Park, Cuhung-Ming Sun, John C. Slater, Tadashi Inoue, Christopher P. Borella, John J. Walsh, Ralph J. Bernacki, Paula Pera, Jean Veith, Ezio Bombzrdelli, Antonella Riva, Srinivasa Rao, Hifeng He, George A. Orr, Susan B. Horwitz, Samuel J. Danishefsky, Giovanni Scambia, and Cristiano Ferlini
5:Discodermolide and Taxol: A Synergistic Drug Combination in Human Carcinoma Cell Lines, Susan Band Horwitz, Laura A. Martello, Chia-Ping Y. Yang, Amos B. Smith, III, and Hayley M. McDaid
6:Highly Efficient Semisynthesis of Biologically Active Epothilone Derivatives, Gregory D. Vite, Robert M. Borzilleri, Soong-Hoon Kim, Alicia Regueiro-Ren, W. Griffith Humphreys, and Francis Y. F. Lee
7:Synthetic and Semisynthetic Analogs of Epothilones: Chemistry and Biological Activity, Karl-Heinz Altmann, Marcel J. J. Blommers, Giorgio Caravatti, Andreas Florsheimer, Kyriacos C. Nicolaou, Terrence O'Reilly, Alfred Schmidt, Dieter Schinzer, and Markus Wartmann
8:Synthesis and Biological Activity of Epothilones, Ulrich Klar, Werner Skuballa, Bernd Buchmann, Wolfgang Schwede, Thomas Bunte, Jens Hoffmann, and Rosemarie B. Lichtner
9:Epothelones and Sarcodictyins: From Combinatorial to Designed Analogs, Nicolas Winssinger and K. C. Nicolaou
10:Synthesis and Structure-Activity Relationship Studies of Cryptophycins: A Novel Class of Potent Antimitotic Tumor Depsipeptides, Chuan Shih, Rima S. Al-Awar, Andrew H. Fray, Michael J. Martinelli, Eric D. Moher, Bryan H. Norman, Vinod F. Patel, Richard M. Schultz, John E. Toth, David L. Varie, Thomas H. Corbett, and Richard E. Moore
11:Farnesyltransferase Inhibitors as Potential Anticancer Agents, J. B. Gibbs, N. J. Anthony, I. Bell, C. A. Buser, J. P. Davide, S. J. deSolms, C. Dinsmore, S. L. Graham, G. D. Hartman, D. C. Heimbrook, H. Huber, K. S. Koblan, N. E. Kohl, R. B. Lobell, and T. M. Williams
12:Farnesyltransferase Inhibitors: From Squalene Synthase Inhibitors to the Clinical Agent BMS-214662, John T. Hunt
13:Inhibiting Farnesyl Protein Transferase with Sch-66336: Potentially a Selective Non-Cytotoxic herapy for Human Cancer, A. G. Taveras, F. G. Njoroge, R. J. Doll, J. Kelly, S. Remiszewski, A. K. Mallams, C. S. Alvarez, J. del Rosario, R. R. Rossman, B. Vibulbhan, P. Pinto, J. Deskus, M. Connolly, J. Wang, J. Desai, R. Wolin, A. Afonso, A. B. Cooper, D. F. Rane, Y.-T. Liu, C. J. Aki, J. Chao, C. Strickland, P. Weber, M. Liu, M. S. Bryant, A. A. Nomeir, R. Patton, L. Wang, L. James, D. Carr, P. Kirschmeier, W. R. Bishop, V. Girijavallabhan, and A. K. Ganguly
14:Pyrrolo[2,3-d]pyrimidine and Pyrazolo[3,4-d]pyrimidine Derivatives as Selective Inhibitors of the EGF Receptor Tyrosine Kinase, G. Caravatti, J. Bruggen, E. Buchdunger, R. Cozens, P. Furet, N. Lydon, T. O'Reilly, and P. Traxler
15:STI571: A New Treatment Modality for CML, Jurg Zimmermann, Pascal Furet, and Elisabeth Buchdunger
16:The Discovery and Development of Second-Generation Matrix Metalloproteinase Inhibitors for the Treatment of Cancer, Andy Baxter and John Montana
17:Prospects for Anti-Angiogenic Therapies Based upon VEGF Inhibition, Pascal Furet and Paul W. Manley
18:Carbohydrate-Based Tumor Antigens as Anti-Tumor Vaccine Agents, Jennifer R. Allen and Samuel J. Danishefsky
19:Drugs to Enhance the Therapeutic Potency of Anti-Cancer Antibodies, Walter A. Blattler and Ravi V. J. Chari
Author Index
