Advances in Agrochemicals

Ion Channels and G Protein-Coupled Receptors (GPCRs) as Targets for Pest Control Volume 1: Ion Channels and Gap Junctions

Edited by Aaron D. Gross, Yoshihisa Ozoe, and Joel R. Coats

American Chemical Society

ACS Symposium Series

Features an array of international experts in the fields of ion channels, G-protein coupled receptors (GPCRs), and gap junctions
Promotes a broader understanding of how endogenous biogenic amines function at various neuroreceptors and the mechanisms by which some insecticides interfere with normal function at those receptors

Advances in Agrochemicals

Ion Channels and G Protein-Coupled Receptors (GPCRs) as Targets for Pest Control Volume 1: Ion Channels and Gap Junctions

Edited by Aaron D. Gross, Yoshihisa Ozoe, and Joel R. Coats

American Chemical Society

Description

This book features contributions from the most highly regarded insecticide scientists in the world. Each of their chapters provides molecular insight into well-known targets, prospective new targets, or creative novel techniques for examining interactions between insecticides and their target sites or for evaluating compounds in search of more potent, more selective, or more environmentally friendly active ingredients. An overview of research on voltage-gated sodium channels is especially relevant given the number of historically important and current insecticides that assert their toxic actions at those sites. Other chapters address new methods for investigating action of insecticides (microtransplant techniques and gap junctions), insecticide effects on highly important species (mosquitoes and honey bees), or chemical prospecting in cultured strains of fungi. This book serves as a timely update on several critically important groups of insecticide chemistry and can serve as a valuable reference volume for the readers.

Advances in Agrochemicals

Ion Channels and G Protein-Coupled Receptors (GPCRs) as Targets for Pest Control Volume 1: Ion Channels and Gap Junctions

Edited by Aaron D. Gross, Yoshihisa Ozoe, and Joel R. Coats

American Chemical Society

ACS Symposium Series

Preface
1. Agrochemical Discovery - Building the Next Generation of Insect Control Agents
2. Ligand-Gated Chloride Channels and Phenolamine GPCRs Are Important Targets of Pest Control Chemicals
3. Targeting Voltage-Gated Sodium Channels for Insect Control: Past, Present, and Future
4. Realizing the Potential: Improving a Microtransplantation Assay Based on Neurolemma-Injected Xenopus Oocytes
5. Recent Advances in the Functional Characterization of Honeybee Voltage-Gated Ca2+ Channels
6. Mosquito Gap Junctions: Molecular Biology, Physiology, and Potential for Insecticide Development
7. Glutamate Receptor-Cation Channel Complex: An Unexploited Target for Mosquito Control
8. Metabolites of Induced Fungi: A Potential Chemical Library for Next-Generation Pesticides
Editors' Biographies
Indexes

Advances in Agrochemicals

Ion Channels and G Protein-Coupled Receptors (GPCRs) as Targets for Pest Control Volume 1: Ion Channels and Gap Junctions

Edited by Aaron D. Gross, Yoshihisa Ozoe, and Joel R. Coats

American Chemical Society

ACS Symposium Series

Author Information

Dr. Aaron Gross is an Assistant Professor of Physiology and Toxicology in the Department of Entomology at Virginia Polytechnic Institute and State University. He earned his doctoral degree from Iowa State University of Science and Technology, and his postdoctoral research training was at the Emerging Pathogens Institute, University of Florida. His research interest include the discovery, and understanding the biochemical and neurophysiological mechanisms of action of naturally occurring and synthetic pesticides, with the goal of controlling arthropods that are important vectors of human and animal health.

Dr. Yoshihisa Ozoe is a specially appointed professor at Shimane University, Japan. He earned his doctoral degree in agricultural chemistry from Kyushu University, Japan, in 1982. He joined Dr. Fumio Matsumura's group at Michigan State University (1982-1984) and at University of California - Davis (1991). His research focus is on ligand-gated ion channels and G protein-coupled receptors as targets of insecticides. He is the recipient of the PSSJ High-Prospectiveness Award (1985), the PSSJ Prominent-Achievement Award (2004), and the ACS International Award for Research in Agrochemicals (2016).

Joel Coats is Distinguished Professor of Entomology & Toxicology at Iowa State University. He is an insect toxicologist with expertise in natural products as insecticides and insect repellents, including investigations of their selectivity, mechanisms of action, metabolism, synthesis of biorational derivatives and analogs, and quantitative structure-activity relationships (QSAR). A current focus is on uses of terpenes from plant essential oils as repellents, insecticides or synergists. Joel holds 9 patents, has published 11 books and over 200 scientific papers/review articles/book chapters; he started the Toxicology Graduate Program at Iowa State that has run continuously since 1985.