This series provides a detailed review of core examples of novel research and seminal papers that have paved the way for breakthroughs in clinical management. The books discuss the significance of literature which has either stimulated a paradigm shift in therapeutic strategy or been the catalyst for new and improved methods of research, diagnosis or drug development. Providing both a benchmark and an inspiration for future work in the field, this series also gives the reader an insight into the mechanics and infrastructure of how high-quality evidence-based medicine is produced. For each topic a selection of papers is made by a key specialist in the field, together with an analysis of the papers methods and wider importance. For trainees, the series acts as a primer for the application of evidence-based medicine to real-world clinical scenarios and the management of patients in everyday practice. It can also be used as a revision aid to prepare for in-training assessments and exit exams. For specialists, the series channels current opinions from internationally renowned and highly respected members of the community, and may also provide an insight into published material of which the reader has previously been unaware.