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Systems Biology

Edited by Isidore Rigoutsos and Gregory Stephanopoulos

Publication Date - September 2006

ISBN: 9780195300802

366 pages
6-1/8 x 9-1/4 inches

Retail Price to Students: $80.00


The advent of genome sequencing and associated technologies has transformed biologists' ability to measure important classes of molecules and their interactions. This expanded cellular view has opened the field to thousands of interactions that previously were outside the researchers' reach. The processing and interpretation of these new vast quantities of interconnected data call for sophisticated mathematical models and computational methods. Systems biology meets this need by combining genomic knowledge with theoretical, experimental and computational approaches from a number of traditional scientific disciplines to create a mechanistic explanation of cellular systems and processes.

Systems Biology I: Genomics and Systems Biology II: Networks, Models, and Applications offer a much-needed study of genomic principles and their associated networks and models. Written for a wide audience, each volume presents a timely compendium of essential information that is necessary for a comprehensive study of the subject. The chapters in the two volumes reflect the hierarchical nature of systems biology. Chapter authors-world-recognized experts in their fields-provide authoritative discussions on a wide range of topics along this hierarchy. Volume I explores issues pertaining to genomics that range from prebiotic chemistry to noncoding RNAs. Volume II covers an equally wide spectrum, from mass spectrometry to embryonic stem cells. The two volumes are meant to provide a reliable reference for students and researchers alike.


"The editors have assembled a fascinatingly diverse set of contributions by leading experts on topics ranging from sequence analysis, structural studies, and expression analysis to exploring molecular interaction networks, their influence on phenotypes, and their applications to fundamental problems such as physiology, development, and evolution. These two volumes provide a well-timed and reasonably comprehensive account of major areas in the emerging subject of systems biology."--The Quarterly Review of Biology

Table of Contents

    1. Mass Spectrometry in Systems Biology 3, Cristian I. Ruse & John R. Yates III
    2. Mathematical Modeling and Optimization Methods for De Novo Protein Design 42, C. A. Floudas & H. K. Fung
    3. Molecular Simulation and Systems Biology 67, William C. Swope, Jed W. Pitera, & Robert S. Germain
    4. Global Gene Expression Assays: Quantitative Noise Analysis 103, G. A. Held, Gustavo Stolovitzky, & Yuhai Tu
    5. Mapping the Genotype-Phenotype Relationship in Cellular Signaling Networks: Building Bridges Over the Unknown 137, Jason A. Papin, Erwin P. Gianchandani, & Shankar Subramaniam
    6. Integrating Innate Immunity into a Global "Systems" Context: The Complement Paradigm Shift 169, Dimitrios Mastellos & John D. Lambris
    7. Systems Biotechnology: Combined in Silico and Omics Analyses for the Improvement of Microorganisms for Industrial Applications 193, Sang Yup Lee, Dong-Yup Lee, Tae Yong Kim, Byung Hun Kim, & Sang Jun Lee
    8. Genome-Scale Models of Metabolic and Regulatory Networks 232, Markus J. Herrgård & Bernhard Ø. Palsson
    9. Biophysical Models of the Cardiovascular System 265, Raimond L. Winslow, Joseph. L. Greenstein, & Patrick A. Helm
    10. Embryonic Stem Cells as a Module for Systems Biology 297, Andrew M. Thomson, Paul Robson, Huck Hui Ng, Hasan H. Otu, & Bing Lim
    Index 319

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