Advance Praise

“With the publication in 1911 of Dementia Praecox or the Group of Schizophrenias by Eugene Bleuler, the classical distinction first made by Emil Kraepelin between dementia praecox and manic-depressive illness became blurred and over the next eighty years schizophrenia received extensive scholarly attention to the neglect of manic-depressive illnesses. This unfortunate state of affairs was dramatically rectified with the introduction of lithium as a treatment for manic-depressive illness and with Goodwin and Jamison’s publication in 1990 of the first edition of their now classic text on the illness. Since the appearance of that extraordinary work, the manic-depressive illnesses have assumed their rightful central role in both our appreciation of the burden of mental illness to which they contribute and our appreciation of the fascinating window on the biology of emotion that they open up for all of us. Since its appearance, the Goodwin-Jamison text has been on the book shelf of almost every psychiatrist. Equally important, this great work has provided the scientific underpinning—the platform—for the remarkable growth of knowledge about manic-depressive illness that has emerged since then.

“Now, seventeen years later, Goodwin and Jamison have harvested the intellectual growth which the earlier volume has spawned and published an extraordinary second edition. Here Goodwin and Jamison capture once again the whole range of the current views of these disorders in a way that points to the future, not only for those who treat people with these recurrent illnesses but for all interested in understanding the enormous scientific growth that the psychobiology of affect has experienced in the last decade and a half.

“This book has no peer. It again has set the standard by which all textbooks in psychiatry will be judged.”
—Eric R. Kandel, MD, University Professor of Physiology and Cell Biophysics, Psychiatry, Biochemistry and Molecular Biophysics at Columbia University and winner of the 2000 Nobel Prize for Medicine

“In a dazzlingly lucid, extensively researched, and amazingly comprehensive display of scholarship, this book remains the authoritative masterpiece on manic-depressive illness. The authors have mastered the complex jargon of the geneticist, the neuroscientist, and the futurist, covering pertinent studies from the drosophila circadian clock mechanisms to the growing neuropathological findings in post-mortem brains. It truly is a masterpiece of writing clarity. Their blue-tinted illustrations make the complex topics they tackle in critical analysis of the neurotransmitter-based hypotheses of disease and their complex intracellular signal transduction pathways more clear than many textbooks. I hope they don't wait another 17 years for the third edition.”
—Floyd Bloom, MD, Professor Emeritus, Molecular and Integrative Neuroscience Department, The Scripps Research Institute, and former editor-in-chief of the journal Science

“Bipolar disorder is not rare; it has a great impact in terms of creativity and risk-taking initiatives (successful and unsuccessful) in every walk of life. It is the pathological amplification of the normal mild highs (falling in love) or lows (grief) that each of us experiences. We are grateful to have an updated edition of the classic work on bipolar disorder; with great expertise and fine judgment the authors have admirably condensed the findings of the exponential development in the literature and international scientific endeavor into in a single volume. Like the previous edition, it sets the gold standard for the general reader, students, teachers, scientists, health care professionals, and for patients and their relatives.”
Jules Angst, MD, Professor Emeritus of Psychiatry, University of Zurich, Switzerland

“This is the Bible of manic-depressive illness and recurrent depression. It is the secure basis for all kinds of scientific and clinical expeditions. It unifies an immense past knowledge with the standards of the present and creates the roadmap for the future. In this book, no field and no aspect of mood and mood-related disorders remain uncovered.”
—Prof. Dr. med. Dr. h. c. Andreas Marneros, Psychiatric University Clinic, Halle-Wittenberg/Germany

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