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Biochemistry and Molecular Biology

Sixth Edition

Despo Papachristodoulou, Alison Snape, William H. Elliott, and Daphne C. Elliott

June 2018

ISBN: 9780198768111

640 pages

Price: £39.99

Integrated coverage of biochemistry and molecular cell biology, focusing on the essential principles that underpin modern life sciences.



The ideal text for any bioscience student encountering biochemistry and molecular cell biology for the first time. Exceptionally clear explanations, frequent diagrams, and a user-friendly design and layout ensure that the text provides a perfect introduction to this complex yet fascinating subject area.

  • Accessible writing style and carefully gauged level of detail make the text ideal for students encountering the subject for the first time
  • Its broad coverage takes readers from the basic building blocks of life right through to metabolism, gene regulation, cell signalling and the immune system
  • Clear sub headings and extensive cross referencing make the text easy to navigate and allow chapters to be read in any order
  • The user-friendly design and layout is complemented by frequent diagrams to illustrate important concepts

New to this edition

  • The opening section has been restructured to enhance understanding of core introductory principles, with greater coverage of basic concepts such as chemical bonding and more worked examples of numerical problems
  • Updated content on manipulating DNA and genes, incorporating gene editing and other recent developments in the field
  • Entirely updated figures and diagrams are easier to interpret and help explain complex processes
  • Summary sections are redesigned to form bulleted lists, providing a consolidation of difficult concepts
  • End of chapter questions and additional reading have been re-worked to include more guidance for students and lecturers about their use
  • An extended selection of online resources with additional Multiple Choice Questions for each chapter

About the Author(s)

Despo Papachristodoulou, Reader in Biochemistry and Medical Education, King's College London, Alison Snape, Senior Lecturer in Biochemistry, King's College London, William H. Elliott, Department of Biochemistry, University of Adelaide, Australia, and Daphne C. Elliott, Department of Biochemistry, Flinders University, Adelaide, Australia

Dr Alison Snape is Programme Director for the BSc in Biomedical Science and also Lecturer in Biochemistry at King's College London. Her research interests include gene expression and differentiation in early embryonic development. Dr Snape has extensive experience of teaching biochemistry and molecular biology to undergraduates and organises modules for first year students of their BSc Biosciences programmes.

Dr Despo Papachristodoulou is Reader in Biochemistry and Medical Education, and also Head of Preclinical Medicine at King's College London School of Medicine. Her research interests include diabetes and diabetic complications, insulin metabolism, intermediary metabolism, nutrition, medical education, and curriculum development.

Table of Contents

    Part 1: Basic concepts of life
    1: The basic molecular themes of life
    2: Cells and viruses
    3: Energy considerations in biochemistry
    Part 2: Structure and function of proteins and membranes
    4: The structure of proteins
    5: Methods in protein investigation
    6: Enzymes
    7: The cell membrane and membrane proteins
    8: Muscle contraction, the cytoskeleton, and molecular motors
    Part 3: Metabolism and Nutrition
    9: General principles of nutrition
    10: Food digestion, absorption and distribution to the tissues
    11: The storage fuels: Mechanisms of transport, storage, and mobilization of carbohydrate and fat
    12: Principles of energy release from food
    13: Glycolysis, the TCA cycle, and the electron transport system
    14: Energy release from fat
    15: An alternative pathway of glucose oxidation: The pentose phosphate pathway
    16: Synthesis of glucose (gluconeogenesis)
    17: Synthesis of fat and related compounds
    18: Nitrogen metabolism: amino acid metabolism
    19: Nitrogen metabolism: nucleotide metabolism
    20: Mechanisms of metabolic control and their applications to metabolic integration
    21: Raising electrons of water back up the energy scale: photosynthesis
    Part 4: Information storage and utilization
    22: The genome
    23: DNA synthesis, repair and recombination
    24: Gene transcription
    25: Protein synthesis and controlled protein breakdown
    26: Control of gene expression
    27: Protein sorting and delivery
    28: Manipulating DNA and genes
    Part 5: Cells and tissues
    29: Cell signalling
    30: The cell cycle, cell division, cell death and cancer
    Part 6: Protective mechanisms against disease
    31: Blood clotting, xenobiotic metabolism, and reactive oxygen species
    32: The immune system


"Easy to read with good use of simple figures and plenty of internal cross-references to other chapters or relevant pages. I was impressed with the inclusion of some very up to date findings." - Dr Peter Morris, School of Life Sciences, Heriot-Watt University

"I don't know of any other biology/biochemistry book that explains DNA replication as well as this one." - Lynn Rogers, School of Molecular and Biomedical Science, Adelaide University

"The style is very clear, logical and systematic. The diagrams complement the text well." - Dr Momna Hejmadi, Department of Biology and Biochemistry, University of Bath

"Good entry level biochemistry textbook that gives students an overview of the diversity of biochemistry and that introduces abstract concepts in a well-explained and accessible way." - Dirk Wildeboer, Natural Sciences, Middlesex University

"This textbook presents classical biochemistry material with a balanced emphasis on details and conceptual understanding. Explanations are given in a conversational manner so that students are not distracted by an over-whelming amount of new terminology." - Amanda Storm, Biology, James Madison University

Additional Resources

Online Resources:
The online resources to accompany this text include:

For registered adopters of the book:
· Figures from the book available to download

For students:
· Further reading organised by chapter
· An extensive bank of multiple-choice questions to support self-directed learning
· Links to 3D molecular structures in Protein Data Bank

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