Journals Higher Education

$63.00

Hardcover

01 October 1998

384 Pages | 75 illus

6-1/8 x 9-1/4 inches

ISBN: 9780195112399


Bookseller Code (05)

Cover

Transcription Factors and Human Disease

Gregg L. Semenza

Oxford Monographs on Medical Genetics

Transcription Factors and Human Disease presents the basic science of transcriptional regulation and the inherited human diseases attributable to mutations in DNA sequences encoding transcription factors in somatic cell genetic diseases (cancer) and epigenetic disease (teratogenesis) is discussed, as well as the effect of specific mutations on transcription factor activity and the relationship between transcriptional dysregulation, dominant or recessive inheritance patterns, and disease pathogenesis. This book thus provides a direct connection between molecular defects in transcriptional regulation and human pathophysiology.

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